Cited by 117Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases

Sergeant, N, David, J.-P, Lefranc, D, Vermersch, P, Wattez, A, Delacourte, A·1997·FEBS Letters

Abstract

Tau proteins aggregate into different neuronal inclusions in several neurodegenerative disorders. In Alzheimer's disease (AD), hyperphosphorylated Tau from paired helical filaments (PHF) of neurofibrillary tangles, named PHF‐Tau, have an electrophoretic profile with four main bands (Tau 55, 64, 69, 74 kDa). In Pick's disease, phosphorylated Tau from Pick bodies are made of two major components (Tau 55, 64 kDa) and a minor 69 kDa. Here we show, using specific antibodies against translated exon 2, 3 or 10 of Tau isoforms, that the set of Tau isoforms engaged in the most insoluble part of PHF in AD is made of Tau isoforms with exon 10 while they are lacking in phosphorylated Tau from Pick's disease. Our results suggest that specific sets of Tau isoforms distinguish between typical neuronal inclusions.

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Crossref · 10.1016/s0014-5793(97)00859-4

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Authors
Sergeant, N., David, J.-P., Lefranc, D., Vermersch, P., Wattez, A., & Delacourte, A.
Affiliations
Inserm (FR)
Corresponding author
Delacourte, A
Venue
FEBS Letters
Publisher
Wiley
Published
1997-08-04
Volume
412
Issue
3
Pages
578-582
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2017064090
Cited by
117
References
33
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 4
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sanofi
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
tau protein, tau isoforms, phosphorylated tau, Alzheimer's disease, Pick's disease, paired helical filaments, Pick bodies, neurofibrillary tangles, neuronal inclusions, exon 10
MeSH terms
Alzheimer Disease, Dementia, Humans, Isomerism, Molecular Weight, Phosphorylation, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Neurofibrillary Tangles, tau Proteins

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