Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA
Abstract
We measured the relative levels of exon 10 containing and exon 10 deleted tau mRNAs in multiple areas of Alzheimer disease (AD) and normal brain. Compared with normal brain, we found a 3.4-fold upregulation of exon 10 plus and a 1.9-fold downregulation of exon 10 minus mRNAs in areas of AD brain with a heavy burden of neurofibrillary tangles. These data suggest that tangle formation in AD is initially determined by transcriptional factors and is not exclusively caused by post-translational events.
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4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain.
“Expression of tau isoforms in AD brain is complicated; although it is still under debate that whether the overall 3R:4R tau ratio is altered, several studies support a notion that 4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain [111, 113–118].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [115]
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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
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- Authors
- Yasojima, K., McGeer, E. G., & McGeer, P. L.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, P.L.
- ORCID
- McGeer, P.L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 831
- Issue
- 1-2
- Pages
- 301-305
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1999895781
- Cited by
- 51
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 6
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer Society
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- Alzheimer's disease, exon 10, exon 10 deletion, neurofibrillary tangles, transcriptional regulation, brain regions
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Exons, Humans, Middle Aged, RNA, Messenger, Up-Regulation, Case-Control Studies, Neurofibrillary Tangles, tau Proteins, Reverse Transcriptase Polymerase Chain Reaction
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