Cited by 117Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases

Sergeant, N, David, J.-P, Lefranc, D, Vermersch, P, Wattez, A, Delacourte, A·1997·FEBS Letters

DOI 10.1016/s0014-5793(97)00859-4

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Abstract

Tau proteins aggregate into different neuronal inclusions in several neurodegenerative disorders. In Alzheimer's disease (AD), hyperphosphorylated Tau from paired helical filaments (PHF) of neurofibrillary tangles, named PHF‐Tau, have an electrophoretic profile with four main bands (Tau 55, 64, 69, 74 kDa). In Pick's disease, phosphorylated Tau from Pick bodies are made of two major components (Tau 55, 64 kDa) and a minor 69 kDa. Here we show, using specific antibodies against translated exon 2, 3 or 10 of Tau isoforms, that the set of Tau isoforms engaged in the most insoluble part of PHF in AD is made of Tau isoforms with exon 10 while they are lacking in phosphorylated Tau from Pick's disease. Our results suggest that specific sets of Tau isoforms distinguish between typical neuronal inclusions.

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Authors: Sergeant, N., David, J.-P., Lefranc, D., Vermersch, P., Wattez, A., & Delacourte, A.
Affiliations: Inserm (FR)
Corresponding author: Delacourte, A
ORCID: Sergeant, N
Vermersch, P
Venue: FEBS Letters
Publisher: Wiley
Published: 1997-08-04
Volume: 412
Issue: 3
Pages: 578-582
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(97)00859-4
OpenAlex: W2017064090
Cited by: 117
References: 33
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 4
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 163 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Sanofi
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: tau protein, tau isoforms, phosphorylated tau, Alzheimer's disease, Pick's disease, paired helical filaments, Pick bodies, neurofibrillary tangles, neuronal inclusions, exon 10
MeSH terms: Alzheimer Disease, Dementia, Humans, Isomerism, Molecular Weight, Phosphorylation, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Neurofibrillary Tangles, tau Proteins

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Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases

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