The DOI matches its Crossref record.
Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1
Abstract
cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with 11 transmembrane domains and one nucleotide binding site motif. It is strongly expressed in kidney, trachea, bone marrow and fetal liver and in several human cancer cell lines, but not in adult liver. When expressed in HEK293 cells, OCTN1 exhibited saturable and pH‐dependent [3 H]tetraethyl ammonium uptake with higher activity at neutral and alkaline pH than at acidic pH. Furthermore, treatment with metabolic inhibitors reduced the uptake, which is consistent with the presence of the nucleotide binding site sequence motif. Although its subcellular localization and detailed functional characteristics are not clear at present, OCTN1 appears to be a novel proton antiporter that functions for active secretion of cationic compounds across the renal epithelial brush‐border membrane. It may play a role in the renal excretion of xenobiotics and their metabolites.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Inflammatory bowel disease: cause and immunobiology
Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147
Ergothioneine; antioxidant potential, physiological function and role in disease
Cheah, I. K., & Halliwell, B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.017 · Cited by 514
EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS
Shitara, Y., Sato, H., & Sugiyama, Y. (2005) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121444 · Cited by 336
Yabuuchi, H., Tamai, I., Nezu, J.-I., Sakamoto, K., Oku, A., Shimane, M., Sai, Y., & Tsuji, A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38199-6 · Cited by 316
Self-citationThe unusual amino acid L-ergothioneine is a physiologic cytoprotectant
Paul, B. D., & Snyder, S. H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.163 · Cited by 304
Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1
Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., et al. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0076-z · Cited by 206
Self-citationCarnitine transport: Pathophysiology and metabolism of known molecular defects
Tein, I. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1024481016187 · Cited by 140
Tamai, I. (2013) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1816 · Cited by 141
Self-citationThe ergothioneine transporter controls and indicates ergothioneine activity — A review
Gründemann, D. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2011.12.001 · Cited by 111
Grigat, S., Harlfinger, S., Pal, S., Striebinger, R., Golz, S., Geerts, A., Lazar, A., Schömig, E., & Gründemann, D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.04.015 · Cited by 72
Koch, A., König, B., Stangl, G. I., & Eder, K. (2008) · Experimental Biology and Medicine · doi:10.3181/0706-rm-168 · Cited by 61
Sai, Y. (2005) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.20.91 · Cited by 60
Self-citationSpecificity of the ergothioneine transporter natively expressed in HeLa cells
Tucker, R. A. J., Cheah, I. K., & Halliwell, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.122 · Cited by 38
Huang, W., Shaikh, S. N., Ganapathy, M. E., Hopfer, U., Leibach, F. H., Carter, A. L., & Ganapathy, V. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00219-1 · Cited by 22
Shimizu, T., Kijima, A., Masuo, Y., Ishimoto, T., Sugiura, T., Takahashi, S., Nakamichi, N., & Kato, Y. (2015) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00109 · Cited by 8
Metadata
- Authors
- Tamai, I., Yabuuchi, H., Nezu, J.-I., Sai, Y., Oku, A., Shimane, M., & Tsuji, A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-12-08
- Volume
- 419
- Issue
- 1
- Pages
- 107-111
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1977244805
- Cited by
- 458
- References
- 0
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
