Cited by 185Fungal and yeast genetics researchIon channel regulation and functionIon Channels and Receptors

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The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating

Fischer, Marc, Schnell, Norbert, Chattaway, Jayne, Davies, Paul, Dixon, Graham, Sanders, Dale·1997·FEBS Letters

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Abstract

The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel α1‐subunit genes. Knock‐out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca 2+ influx in response to the α‐mating pheromone. Cch1 is involved in calcium influx and the late stage of the mating process. The cch1 mutant sensitivity against the α‐mating pheromone can be reduced by the addition of extra calcium. The product of this gene is likely to interact with the MID1 gene product in Ca influx or its control.

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“Yeast strains examined were deleted for genes encoding the plasma membrane Cch1p/Mid1p channel complex [40,41]; vacuolar Ca2+ channels Vcx1p and Pmc1p, and Yvc1p [42–45]; and the ER-associated P-type ATPase Spf1p [46].”
Background
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“We also expressed full length CNGC13 in yeast cch1/mid1 mutant to test its possible channel activity (Fischer et al., 1997).”
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Authors: Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D.
Affiliations: University of York (GB)
ORCID: Davies, Paul
Sanders, Dale
Venue: FEBS Letters
Publisher: Wiley
Published: 1997-12-15
Volume: 419
Issue: 2-3
Pages: 259-262
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(97)01466-x
OpenAlex: W2155529170
Cited by: 185
References: 17
Citations by year: 2026: 7 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 11 · 2012: 12
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 30 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: Saccharomyces cerevisiae, calcium influx, mating, MID1, knockout mutants, pheromone sensitivity, calcium-dependent signaling
MeSH terms: Base Sequence, Calcium, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Saccharomyces cerevisiae, Calcium Channels, Ion Transport, Saccharomyces cerevisiae Proteins

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The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating

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