Cited by 185Fungal and yeast genetics researchIon channel regulation and functionIon Channels and Receptors

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The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating

Fischer, Marc, Schnell, Norbert, Chattaway, Jayne, Davies, Paul, Dixon, Graham, Sanders, Dale·1997·FEBS Letters

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Abstract

The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel α1‐subunit genes. Knock‐out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca 2+ influx in response to the α‐mating pheromone. Cch1 is involved in calcium influx and the late stage of the mating process. The cch1 mutant sensitivity against the α‐mating pheromone can be reduced by the addition of extra calcium. The product of this gene is likely to interact with the MID1 gene product in Ca influx or its control.

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Crossref · 10.1016/s0014-5793(97)01466-x

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“The Arabidopsis MCA1 was identified by its ability to complement the low Ca2+ and related lethality phenotypes of mid1 (mating induced death1) yeast mutants upon mating induction (Iida et al., 1994; Fischer et al., 1997; Nakagawa et al., 2007; Yamanaka et al., 2010; Kurusu et al., 2012a, 2012c).”
BackgroundInfluential
Functional analysis of a putative Ca2+ channel gene TaTPC1 from wheat
Wang, Y., Yu, J., Chen, T., Zhang, Z., Hao, Y., Zhang, J., & Chen, S. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri302 · Cited by 68
“Therefore, a more sensitive approach to Ca2+ probing should be used to reveal the transient change in Ca2+ concentration in transgenic plants (Furuichi et al., 2001).”
BackgroundInfluential
Avian magnetite-based magnetoreception: a physiologist's perspective
Cadiou, H., & McNaughton, P. A. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0423.focus · Cited by 71
Involvement of the putative Ca2+-permeable mechanosensitive channels, NtMCA1 and NtMCA2, in Ca2+ uptake, Ca2+-dependent cell proliferation and mechanical stress-induced gene expression in tobacco (Nicotiana tabacum) BY-2 cells
Kurusu, T., Yamanaka, T., Nakano, M., Takiguchi, A., Ogasawara, Y., Hayashi, T., Iida, K., Hanamata, S., Shinozaki, K., Iida, H., et al. (2011) · Journal of Plant Research · doi:10.1007/s10265-011-0462-6 · Cited by 66
“In yeast, Mid1 and Cch1, a homologue of the a1 subunit of the mammalian voltage-gated Ca channels, constitute the sole high-affinity Ca influx system and therefore the phenotypes of mid1 mutants are quite similar to mid1 cch1 double mutants with respect to Ca uptake and mating pheromone-induced death (Fischer et al. 1…”
NSC1: a novel high‐current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae
Bihler, H. J., Slayman, C. L., & Bertl, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00832-1 · Cited by 66
Phylogeny Unites Animal Sodium Leak Channels with Fungal Calcium Channels in an Ancient, Voltage-Insensitive Clade
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss182 · Cited by 64
KP4 fungal toxin inhibits growth in Ustilago maydis by blocking calcium uptake
Gage, M. J., Bruenn, J. A., Fischer, M. J. C., Sanders, D., & Smith, T. J. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02554.x · Cited by 62
“This finding is consistent with the observation that calcium channels play an important role in the life cycle of S. cerevisiae (Fischer et al., 1997).”
BackgroundResultSelf-citation
The Involvement of the Mid1/Cch1/Yvc1 Calcium Channels in Aspergillus fumigatus Virulence
de Castro, P. A., Chiaratto, J., Winkelströter, L. K., Bom, V. L. P., Ramalho, L. N. Z., Goldman, M. H. S., Brown, N. A., & Goldman, G. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103957 · Cited by 60
“Cch1 [17], [18], the stretch-activated calcium channel/regulatory”
Direct Regulation of Genes Involved in Glucose Utilization by the Calcium/Calcineurin Pathway
Ruiz, A., Serrano, R., & Ariño, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708683200 · Cited by 60
Deletion of the putative stretch-activated ion channel Mid1 is hypervirulent in Aspergillus fumigatus
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Vacuolar H+-ATPase (V-ATPase) Promotes Vacuolar Membrane Permeabilization and Nonapoptotic Death in Stressed Yeast
Kim, H., Kim, A., & Cunningham, K. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363390 · Cited by 60
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Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress
Mishra, R., van Drogen, F., Dechant, R. C., Oh, S., Jeon, N. L., Lee, S. S., & Peter, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709079114 · Cited by 55
“While Mid1 in complex with Cch1 forms a stretch-activated Ca channel (30, 31), the cytoplasmic domain of Mid2 binds and activates Rom2/Rho1 upon mechanostress (21).”
Background
Ion-channel blocker sensitivity of voltage-gated calcium-channel homologue Cch1 in Saccharomyces cerevisiae
Teng, J., Goto, R., Iida, K., Kojima, I., & Iida, H. (2008) · Microbiology · doi:10.1099/mic.0.2008/021089-0 · Cited by 53
“The yeast Saccharomyces cerevisiae has one orthologue, termed Cch1, of the pore-forming a1 subunit of mammalian VGCCs (Fischer et al., 1997; Paidhungat & Garrett, 1997).”
BackgroundInfluential
Mid1, a Mechanosensitive Calcium Ion Channel, Affects Growth, Development, and Ascospore Discharge in the Filamentous Fungus Gibberella zeae
Cavinder, B., Hamam, A. M., Lew, R. R., & Trail, F. (2011) · Eukaryotic Cell · doi:10.1128/ec.00235-10 · Cited by 53
“Initially characterized in Saccharomyces cerevisiae, the HACS is composed minimally of Cch1, an L-type voltage gated calcium channel, and Mid1, a stretchactivated nonselective channel capable of being permeated by calcium and acting as the major calcium entry route when calcium availability is low (22, 27, 38), wherea…”
Background
Quantitative description of ion transport via plasma membrane of yeast and small cells
Volkov, V. S. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00425 · Cited by 51
Electrophysiology in the eukaryotic model cell Saccharomyces cerevisiae
Bertl, A., Bihler, H. J., Kettner, C., & Slayman, C. L. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050735 · Cited by 51
“influx during mating [33, 62], and may be cooperative [42]; Two weakly channel-related proteins: YBR086c and”
Background
Sensing and transduction of nutritional and chemical signals in filamentous fungi: Impact on cell development and secondary metabolites biosynthesis
Martı́n, J. F., van den Berg, M. A., van Themaat, E. V. L., & Liras, P. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.04.014 · Cited by 52
Functional Analysis of a Rice Putative Voltage-Dependent Ca2+ Channel, OsTPC1, Expressed in Yeast Cells Lacking its Homologous Gene CCH1
Hashimoto, K., Saito, M., Matsuoka, H., Iida, K., & Iida, H. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch053 · Cited by 49
Role of Fig1, a Component of the Low-Affinity Calcium Uptake System, in Growth and Sexual Development of Filamentous Fungi
Cavinder, B., & Trail, F. (2012) · Eukaryotic Cell · doi:10.1128/ec.00007-12 · Cited by 48
“All strains lacking functional Fig1 failed to develop perithecia, including the double and triple mutants with the HACS components Mid1 and Cch1, although they produced the characteristic black pigment seen in the top 2 to 4 mm of the medium after induction (Fig.”
BackgroundInfluential
It’s All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes
Wilson, A., Wilken, P. M., van der Nest, M. A., Wingfield, M., & Wingfield, B. (2019) · Genes · doi:10.3390/genes10050330 · Cited by 42
“The high-affinity calcium uptake system (HACS) functions when there are low levels of exogenous calcium and active uptake is required [66,67].”
Background
Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1
Yoshimura, H., Tada, T., & Iida, H. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.020 · Cited by 45
Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
Bonilla, M., & Cunningham, K. W. (2002) · Science s STKE · doi:10.1126/stke.2002.127.pe17 · Cited by 45
The Virally Encoded Fungal Toxin KP4 Specifically Blocks L-Type Voltage-Gated Calcium Channels
Gage, M. J., Rane, S. G., Hockerman, G. H., & Smith, T. J. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12346-2 · Cited by 42
Cell-cycle-dependent regulation of oxidative stress responses and Ca2+ permeable channels NtTPC1A/B in tobacco BY-2 cells
Kadota, Y., Furuichi, T., Sano, T., Kaya, H., Gunji, W., Murakami, Y., Muto, S., Hasezawa, S., & Kuchitsu, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.004 · Cited by 42
Cysteine‐rich domains related to Frizzled receptors and Hedgehog‐interacting proteins
Pei, J., & Grishin, N. V. (2012) · Protein Science · doi:10.1002/pro.2105 · Cited by 41
“to be required for calcium influx and mating in fungi.(36) 38 Most of the fungal Mid1 sequences have a predicted N-terminal signal peptide.”
Background
Calcium homeostasis and signaling in fungi and their relevance forpathogenicity of yeasts and filamentous fungi
Tisi, R., Rigamonti, M. M., Groppi, S., & Belotti, F. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.4.505 · Cited by 41
“As mammalian VGCCs, Cch1 homologues in fungi typically contain positive residues (although reduced in number) in the voltage sensing (S4) domains [57,85,86], suggesting that HACS may”
Background
Thigmo Responses: The Fungal Sense of Touch
Almeida, M. C., & Brand, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0040-2016 · Cited by 42
“The identi ﬁ cation of ScCch1, a homolog of the α -subunit of mammalian voltage-gated L-type Ca 2+ channel (VGCC), ultimately led to the view that Mid1 was not a channel but a subunit, and potentially a regulator, of the Cch1 high-af ﬁ nity calcium uptake sys-tem (HACs) (93 – 96).”
Background
The Yeast Transcription Factor Crz1 Is Activated by Light in a Ca2+/Calcineurin-Dependent and PKA-Independent Manner
Bodvard, K., Jörhov, A., Blomberg, A., Molin, M., & Käll, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053404 · Cited by 39
“the role of the high-affinity calcium channel, Cch1p [44,45].”
BackgroundInfluential
Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus
Zhang, Y., Zheng, Q., Sun, C., Song, J., Gao, L., Zhang, S., Muñoz, A., Read, N. D., & Lü, L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005977 · Cited by 39
Identification and Analysis of Cation Channel Homologues in Human Pathogenic Fungi
Prole, D. L., & Taylor, C. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042404 · Cited by 37
“Ca2+ Channels The genomes of all fungi examined (except the microsporidia) contain a single gene encoding a homologue of the plasma membrane Ca2+ channel Cch1 found in S. cerevisiae (Table 1), which is similar in sequence and topological structure to human voltage-gated Cav channels [36,37] (Figure 4A).”
BackgroundInfluential
Deletion of Mid1, a putative stretch-activated calcium channel in Claviceps purpurea, affects vegetative growth, cell wall synthesis and virulence
Bormann, J., & Tudzynski, P. (2009) · Microbiology · doi:10.1099/mic.0.030825-0 · Cited by 35
“cerevisiae (Fischer et al., 1997; Iida et al., 2004; Paidhungat & Garrett, 1997).”
Molecular cloning in yeast by in vivo homologous recombination of the yeast putative α1 subunit of the voltage‐gated calcium channel
Iida, K., Tada, T., & Iida, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.021 · Cited by 35
The involvement of calcium carriers and of the vacuole in the glucose-induced calcium signaling and activation of the plasma membrane H+-ATPase in Saccharomyces cerevisiae cells
Bouillet, L. É. M., Cardoso, A. S., Perovano, E., Pereira, R. R., Ribeiro, E., Trópia, M. J. M., Fietto, L. G., Tisi, R., Martegani, E., Castro, I. M., et al. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.10.008 · Cited by 33
Sexual pheromone modulates the frequency of cytosolic Ca2+bursts inSaccharomyces cerevisiae
Carbó, N., Tarkowski, N., Ipiña, E. P., Dawson, S. P., & Aguilar, P. S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0481 · Cited by 34
“…depends on the simultaneous presence of three plasma membrane proteins: Cch1, a homologue of the catalytic α-subunit of voltage-gated Ca2+ channels (Fischer et al., 1997; Paidhungat and Garrett, 1997; Muller et al., 2001); Mid1, an integral membrane glycoprotein that physically interacts with…”
Background
Activation of an Essential Calcium Signaling Pathway in Saccharomyces cerevisiae by Kch1 and Kch2, Putative Low-Affinity Potassium Transporters
Stefan, C. P., Zhang, N., Sokabe, T., Rivetta, A., Slayman, C. L., Montell, C., & Cunningham, K. W. (2013) · Eukaryotic Cell · doi:10.1128/ec.00299-12 · Cited by 32
“Given the high sequence similarities between Cch1 and the catalytic subunits of mammalian voltage-gated Ca(2) channels (10, 11), we supposed that activation of HACS during the response to mating pheromones is likely to involve electrical depolarization of the cell membrane.”
Background
Cch1 and Mid1 Are Functionally Required for Vegetative Growth under Low-Calcium Conditions in the Phytopathogenic Ascomycete Botrytis cinerea
Harren, K., & Tudzynski, B. (2013) · Eukaryotic Cell · doi:10.1128/ec.00338-12 · Cited by 31
“For example, in yeast, the mating-induced death phenotype is rescued by elevated Ca(2) (13, 21).”
Background
Ecm7, a regulator of HACS, functions in calcium homeostasis maintenance, oxidative stress response and hyphal development in Candida albicans
Ding, X., Yu, Q., Xu, N., Wang, Y., Cheng, X., Qian, K., Zhao, Q., Zhang, B., Xing, L., & Li, M. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.05.010 · Cited by 30
“Nearly all fungi contain a gene whose protein product is homologous to the catalytic a-subunits of voltage-gated Ca2+ channels (VGCCs) in animals (Fischer et al., 1997; Paidhungat and Garrett, 1997).”
Background
Antihypertensive, Amlodipine Besilate Inhibits Growth and Biofilm of Human Fungal Pathogen Candida
Gupta, P., Chanda, R., Rai, N., Kataria, V., & Kumar, N. (2016) · Assay and Drug Development Technologies · doi:10.1089/adt.2016.714 · Cited by 30
Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae
Courchesne, W. E., Vlasek, C., Klukovich, R., & Coffee, S. (2011) · Archives of Microbiology · doi:10.1007/s00203-010-0673-6 · Cited by 30
“in stress responses, including osmotic stress and other plasma membrane perturbations ( Fischer et al. 1997; Paidhungat and Garrett 1997; Locke et al. 2000; Muller et al. 2001; Bonilla et al. 2002; Matsumoto et al. 2002; Iida et al. 2004).”
Background
Importance of the αC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis
Chin, K., Moeder, W., Abdel-Hamid, H., Shahinas, D., Gupta, D., & Yoshioka, K. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq072 · Cited by 29
“CCH1 has been implicated in Ca influx in response to mating pheromones (Fischer et al., 1997).”
Background
The bacterial secondary metabolite 2,4-diacetylphloroglucinol impairs mitochondrial function and affects calcium homeostasis in Neurospora crassa
Troppens, D. M., Chu, M., Holcombe, L. J., Gleeson, O., O’Gara, F., Read, N. D., & Morrissey, J. P. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.04.006 · Cited by 28
Molecular Dissection of the Hydrophobic Segments H3 and H4 of the Yeast Ca2+ Channel Component Mid1
Tada, T., Ohmori, M., & Iida, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206993200 · Cited by 28
New candidates for mechano‐sensitive channels potentially involved in gravity sensing in A rabidopsis thaliana
Iida, H., Furuichi, T., Nakano, M., Toyota, M., Sokabe, M., & Tatsumi, H. (2013) · Plant Biology · doi:10.1111/plb.12044 · Cited by 27
“The Cch1 protein is weakly homologous in its amino acid sequence to mammalian voltage-gated Ca2+ channel a1 subunits (Fischer et al. 1997; Paidhungat & Garrett 1997; Iida et al. 2004), and cooperates with Mid1 to constitute a Ca2+ influx system in yeast cells.”
Background
Ca2+ homeostasis in the budding yeast Saccharomyces cerevisiae: Impact of ER/Golgi Ca2+ storage
D’hooge, P., Coun, C., Eyck, V. V., Faes, L., Ghillebert, R., Mariën, L., Winderickx, J., & Callewaert, G. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.05.004 · Cited by 25

Authors: Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D.
Affiliations: University of York (GB)
ORCID: Davies, Paul
Sanders, Dale
Venue: FEBS Letters
Publisher: Wiley
Published: 1997-12-15
Volume: 419
Issue: 2-3
Pages: 259-262
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(97)01466-x
OpenAlex: W2155529170
Cited by: 185
References: 17
Citations by year: 2026: 7 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 11 · 2012: 12
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 30 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: Saccharomyces cerevisiae, calcium influx, mating, MID1, knockout mutants, pheromone sensitivity, calcium-dependent signaling
MeSH terms: Base Sequence, Calcium, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Saccharomyces cerevisiae, Calcium Channels, Ion Transport, Saccharomyces cerevisiae Proteins

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The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating

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