A Homolog of Mammalian, Voltage-Gated Calcium Channels Mediates Yeast Pheromone-Stimulated Ca 2+ Uptake and Exacerbates the cdc1 (Ts) Growth Defect

Paidhungat, Madan; Garrett, Stephen

doi:10.1128/mcb.17.11.6339

Cited by 191Fungal and yeast genetics researchIon channel regulation and functionIon Channels and Receptors

A Homolog of Mammalian, Voltage-Gated Calcium Channels Mediates Yeast Pheromone-Stimulated Ca 2+ Uptake and Exacerbates the cdc1 (Ts) Growth Defect

Open access

Paidhungat, Madan, Garrett, Stephen·1997·Molecular and Cellular Biology

DOI 10.1128/mcb.17.11.6339PMC PMC232485

Open this paper in CoChat — free account

Abstract

Previous studies attributed the yeast (Saccharomyces cerevisiae) cdc1(Ts) growth defect to loss of an Mn2+-dependent function. In this report we show that cdc1(Ts) temperature-sensitive growth is also associated with an increase in cytosolic Ca2+. We identified two recessive suppressors of the cdc1(Ts) temperature-sensitive growth which block Ca2+ uptake and accumulation, suggesting that cytosolic Ca2+ exacerbates or is responsible for the cdc1(Ts) growth defect. One of the cdc1(Ts) suppressors is identical to a gene, MID1, recently implicated in mating pheromone-stimulated Ca2+ uptake. The gene (CCH1) corresponding to the second suppressor encodes a protein that bears significant sequence similarity to the pore-forming subunit (alpha1) of plasma membrane, voltage-gated Ca2+ channels from higher eukaryotes. Strains lacking Mid1 or Cch1 protein exhibit a defect in pheromone-induced Ca2+ uptake and consequently lose viability upon mating arrest. The mid1delta and cch1delta mutants also display reduced tolerance to monovalent cations such as Li+, suggesting a role for Ca2+ uptake in the calcineurin-dependent ion stress response. Finally, mid1delta cch1delta double mutants are, by both physiological and genetic criteria, identical to single mutants. These and other results suggest Mid1 and Cch1 are components of a yeast Ca2+ channel that may mediate Ca2+ uptake in response to mating pheromone, salt stress, and Mn2+ depletion.

Integrity signals

Registry

Crossref · 10.1128/mcb.17.11.6339

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Measurement of Cch1 channel activity in a heterologous expression system had been impossible until recently because of the significant challenge posed by molecular cloning of CCH1 due to toxicity of the CCH1 gene or gene product in E. coli cells.
“Unfortunately, the measurement of Cch1 channel activity in a heterologous expression system had been impossible until recently because of the significant challenge posed by the molecular cloning of CCH1 as a result of the toxicity of the CCH1 gene or gene product in Escherichia coli cells (8).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [8]

A simple method for displaying the hydropathic character of a protein
Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,694 · see citing works
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,685 · see citing works
Methods in yeast genetics
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,543 · see citing works
Methods in Yeast Genetics
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911 · see citing works
Primary structure of the receptor for calcium channel blockers from skeletal muscle
Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., & Numa, S. (1987) · Nature · doi:10.1038/328313a0 · Cited by 1,370 · see citing works
A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
Rose, M. D., Novick, P., Thomas, J. H., Botstein, D., & Fink, G. R. (1987) · Gene · doi:10.1016/0378-1119(87)90232-0 · Cited by 1,126 · see citing works
STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS
Catterall, W. A. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002425 · Cited by 950 · see citing works
[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast
Casadaban, M. J., Martínez-Arias, A., Shapira, S. K., & Chou, J. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)00063-4 · Cited by 775 · see citing works
Quantitative evaluation of Escherichia coli host strains for tolerance to cytosine methylation in plasmid and phage recombinants
Woodcock, D. M., Crowther, P. J., Doherty, J. P., Jefferson, S., Decruz, E. E., Noyer-Weidner, M., Smith, S. S., Michael, M., & Graham, M. W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.9.3469 · Cited by 763 · see citing works
Molecular Basis for CA2+ Channel Diversity
Hofmann, F. B., Biel, M., & Flockerzi, V. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002151 · Cited by 459 · see citing works
Direct binding of G-protein βλ complex to voltage-dependent calcium channels
WAARD, M. M. D., Liu, H., Walker, D. S., Scott, V., Gurnett, C. A., & Campbell, K. P. (1997) · Nature · doi:10.1038/385446a0 · Cited by 445 · see citing works
Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases
Cunningham, K. W., & Fink, G. R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.3.351 · Cited by 432 · see citing works
Calcineurin Inhibits VCX 1-Dependent H + /Ca 2 + Exchange and Induces Ca 2 + ATPases in Saccharomyces cerevisiae
Cunningham, K. W., & Fink, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2226 · Cited by 431 · see citing works
Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS
Snutch, T. P., Tomlinson, W. J., Leonard, J. P., & Gilbert, M. (1991) · Neuron · doi:10.1016/0896-6273(91)90073-9 · Cited by 362 · see citing works
The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.
Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37038-2 · Cited by 350 · see citing works
A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.
Supek, F., Supekova, L., Nelson, H., & Nelson, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5105 · Cited by 325 · see citing works
Protein phosphatase type 2B (calcineurin)‐mediated, FK506‐sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.
Nakamura, T., Liu, Y., Hirata, D., Namba, H., Harada, S., Hirokawa, T., & Miyakawa, T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06090.x · Cited by 270 · see citing works
Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.
Cyert, M., & Thorner, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3460 · Cited by 236 · see citing works
Essential role for induced Ca2+ influx followed by [Ca2+]i rise in maintaining viability of yeast cells late in the mating pheromone response pathway. A study of [Ca2+]i in single Saccharomyces cerevisiae cells with imaging of fura-2.
Iida, H., Yagawa, Y., & Anraku, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38311-5 · Cited by 224 · see citing works
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.
Iida, H., Nakamura, H., Ono, T., Okumura, M. S., & Anraku, Y. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8259 · Cited by 218 · see citing works
Calcium-sensitive cls mutants of Saccharomyces cerevisiae showing a Pet- phenotype are ascribable to defects of vacuolar membrane H(+)-ATPase activity
Ohya, Y., Umemoto, N., Tanida, I., Ohta, A., Iida, H., & Anraku, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92798-5 · Cited by 193 · see citing works
Regulation of cellular Ca2+ by yeast vacuoles.
Dunn, T. M., Gable, K. S., & Beeler, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37279-4 · Cited by 192 · see citing works
Structural and Functional Diversity of Voltage-Activated Calcium Channels
WAARD, M. M. D., Gurnett, C. A., & Campbell, K. P. (1996) · Springer eBooks · doi:10.1007/978-1-4899-1775-1_2 · Cited by 145 · see citing works
Ca2+ Transport in Saccharomyces Cerevisiae
Cunningham, K. W., & Fink, G. R. (1994) · Journal of Experimental Biology · doi:10.1242/jeb.196.1.157 · Cited by 145 · see citing works
A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae.
Beeler, T., Gable, K., Zhao, C., & Dunn, T. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37280-0 · Cited by 109 · see citing works
Ca 2+ -Calmodulin Promotes Survival of Pheromone-Induced Growth Arrest by Activation of Calcineurin and Ca 2+ -Calmodulin-Dependent Protein Kinase
Moser, M. J., Geiser, J. R., & Davis, T. N. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4824 · Cited by 104 · see citing works
The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions
Lapinskas, P. J., Lin, S., & Culotta, V. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02561.x · Cited by 103 · see citing works
Urea transport in Saccharomyces cerevisiae
Cooper, T., & Sumrada, R. A. (1975) · Journal of Bacteriology · doi:10.1128/jb.121.2.571-576.1975 · Cited by 100 · see citing works
Regulatory Subunit (CNB1 Gene Product) of Yeast Ca2+/Calmodulin-Dependent Phosphoprotein Phosphatases Is Required for Adaptation to Pheromone
Cyert, M., & Thorner, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3460-3469.1992 · Cited by 82 · see citing works
An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.
Withee, J. L., Mulholland, J., Jeng, R. L., & Cyert, M. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.2.263 · Cited by 80 · see citing works
Protein Phosphatase 2B of Saccharomyces Cerevisiae is Required for Tolerance to Manganese, in Blocking the Entry of ions into the Cells
FARCASANU, I. C., Hirata, D., Tsuchiya, E., Nishiyama, F., & Miyakawa, T. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0712a.x · Cited by 72 · see citing works
Calcium and Microorganisms
Youatt, J. (1993) · Critical Reviews in Microbiology · doi:10.3109/10408419309113524 · Cited by 68 · see citing works
Molecular Genetics of Yeast Ion Transport
Gaber, R. F. (1992) · International review of cytology · doi:10.1016/s0074-7696(08)62679-0 · Cited by 65 · see citing works
Manganese effectively supports yeast cell-cycle progression in place of calcium.
Loukin, S. H., & Kung, C. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.4.1025 · Cited by 62 · see citing works
Ligand-gated calcium channels inside and out
Striggow, F., & Ehrlich, B. E. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80025-1 · Cited by 54 · see citing works
Protein Phosphatase 2B of Saccharomyces Cerevisiae is Required for Tolerance to Manganese, in Blocking the Entry of ions into the Cells
FARCASANU, I. C., Hirata, D., Tsuchiya, E., Nishiyama, F., & Miyakawa, T. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20865.x · Cited by 52 · see citing works
Transport in Saccharomyces cerevisiaePreprint
Cooper, T. (1982) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969180.11b.399 · Cited by 51 · see citing works
The CLS2 gene encodes a protein with multiple membrane-spanning domains that is important Ca2+ tolerance in yeast
Yashiroda, Y., Ohya, Y., & Anraku, Y. (1995) · Molecular and General Genetics MGG · doi:10.1007/bf00288599 · Cited by 38 · see citing works
12 Calcium in Saccharomyces cerevisiae
Davis, T. N. (1995) · Advances in second messenger and phosphoprotein research · doi:10.1016/s1040-7952(05)80014-x · Cited by 21 · see citing works
Ion Channels of Microbes
Palmer, C. P., Batiza, A. F., Zhou, X.-L., Loukin, S. H., Saimi, Y., & Kung, C. (2004) · Springer eBooks · doi:10.1007/978-94-017-0998-9_10 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,773 · see citing works
Calcineurin: Form and Function
Rusnak, F. M., & Mertz, P. S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1483 · Cited by 1,375 · see citing works
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136 · see citing works
MAP Kinase Pathways in the YeastSaccharomyces cerevisiae
Gustin, M., Albertyn, J., Alexander, M., & Davenport, K. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1264-1300.1998 · Cited by 1,010 · see citing works
Lessons from the Genome Sequence ofNeurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
Borkovich, K. A., Alex, L. A., Yarden, O., Freitag, M., Turner, G., Read, N. D., Seiler, S., Bell‐Pedersen, D., Paietta, J. V., Plesofsky, N. S., et al. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.1.1-108.2004 · Cited by 626 · see citing works
Arabidopsis plasma membrane protein crucial for Ca 2+ influx and touch sensing in roots
Nakagawa, Y., Katagiri, T., Shinozaki, K., Qi, Z., Tatsumi, H., Furuichi, T., Kishigami, A., Sokabe, M., Kojima, I., Sato, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607703104 · Cited by 406 · see citing works
N ONSELECTIVE C ATION C HANNELS IN P LANTS
Demidchik, V. V., Davenport, R. J., & Tester, M. A. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.091901.161540 · Cited by 392 · see citing works
Calcium channels in higher plants
White, P. J. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00137-1 · Cited by 357 · see citing works
Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.
Cyert, M. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01552-3 · Cited by 333 · see citing works
Receptor-activated Ca2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca2+ signalling requirements
Barritt, G. J. (1999) · Biochemical Journal · doi:10.1042/bj3370153 · Cited by 299 · see citing works
Essential role of calcineurin in response to endoplasmic reticulum stress
Bonilla, M., Nastase, K. K., & Cunningham, K. W. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2343 · Cited by 255 · see citing works
Regulation of Cation Balance inSaccharomyces cerevisiae
Cyert, M., & Philpott, C. C. (2013) · Genetics · doi:10.1534/genetics.112.147207 · Cited by 253 · see citing works
CRZ1 , a target of the calcineurin pathway in Candida albicans
Karababa, M., Valentino, E., Pardini, G., Coste, A. T., Bille, J., & Sanglard, D. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.05037.x · Cited by 231 · see citing works
A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca 2+ -permeable channel in the yeast vacuolar membrane
Palmer, C. P., Zhou, X., Lin, J., Loukin, S. H., Kung, C., & Saimi, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141036198 · Cited by 230 · see citing works
Iron Regulation of the Major Virulence Factors in the AIDS-Associated Pathogen Cryptococcus neoformans
Jung, W. H., Sham, A. P., White, R., & Kronstad, J. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040410 · Cited by 222 · see citing works
Differential Antifungal and Calcium Channel-Blocking Activity among Structurally Related Plant Defensins
Spelbrink, R. G., Dilmac, N., Allen, A., Smith, T. J., Shah, D. M., & Hockerman, G. H. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.040873 · Cited by 219 · see citing works
A Homolog of Voltage-Gated Ca 2+ Channels Stimulated by Depletion of Secretory Ca 2+ in Yeast
Locke, E. G., Bonilla, M., Liang, L., Takita, Y., & Cunningham, K. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6686-6694.2000 · Cited by 212 · see citing works
Sentinels at the wall: cell wall receptors and sensors
Humphrey, T., Bonetta, D. T., & Goring, D. R. (2007) · New Phytologist · doi:10.1111/j.1469-8137.2007.02192.x · Cited by 211 · see citing works
Characterization of the Calcium-mediated Response to Alkaline Stress in Saccharomyces cerevisiae
Viladevall, L., Serrano, R., Ruiz, A., Doménech, G., Giraldo, J., Barceló, A., & Ariño, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403606200 · Cited by 207 · see citing works
Ion Channels in Microbes
Martinac, B., Saimi, Y., & Kung, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00005.2008 · Cited by 200 · see citing works
Genes for calcium-permeable channels in the plasma membrane of plant root cells
White, P. J., Bowen, H. C., Demidchik, V. V., Nichols, C., & Davies, J. M. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00509-6 · Cited by 197 · see citing works
Genetic Analysis of Calmodulin and Its Targets in Saccharomyces cerevisiae
Cyert, M. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091302 · Cited by 175 · see citing works
Functional Genomic Analysis of Fluconazole Susceptibility in the Pathogenic Yeast Candida glabrata : Roles of Calcium Signaling and Mitochondria
Kaur, R., Castaño, I., & Cormack, B. P. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1600-1613.2004 · Cited by 167 · see citing works
Tryptophan Permease Gene TAT2 Confers High-Pressure Growth in Saccharomyces cerevisiae
Abe, F., & Horikoshi, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8093-8102.2000 · Cited by 170 · see citing works
Mitogen-activated Protein Kinase Stimulation of Ca2+Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast
Bonilla, M., & Cunningham, K. W. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-02-0113 · Cited by 165 · see citing works
Calcium channels in photosynthetic eukaryotes: implications for evolution of calcium‐based signalling
Verret, F., Wheeler, G. L., Taylor, A. R., Farnham, G., & Brownlee, C. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03271.x · Cited by 165 · see citing works
Antifungal Activity of Amiodarone Is Mediated by Disruption of Calcium Homeostasis
Gupta, S. S., Ton, V., Beaudry, V. G., Rulli, S. J., Cunningham, K. W., & Rao, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303300200 · Cited by 161 · see citing works
An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae
Matsumoto, T. K., Ellsmore, A. J., Cessna, S. G., Low, P. S., Pardo, J. M., Bressan, R. A., & Hasegawa, P. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205037200 · Cited by 155 · see citing works
Hyphal Orientation of Candida albicans Is Regulated by a Calcium-Dependent Mechanism
Brand, A., Shanks, S., Duncan, V. M. S., Yang, M., Mackenzie, K. S., & Gow, N. A. R. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.043 · Cited by 154 · see citing works
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans
Cruz, M. C., Fox, D. S., & Heitman, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.1020 · Cited by 150 · see citing works
Evolution of voltage-gated ion channels at the emergence of Metazoa
Moran, Y., Barzilai, M. G., Liebeskind, B. J., & Zakon, H. H. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110270 · Cited by 139 · see citing works
Plants use calcium to resolve salt stress
Bressan, R. A., Hasegawa, P. M., & Pardo, J. M. (1998) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01331-4 · Cited by 142 · see citing works
The yeast cell-wall salvage pathway
Popolo, L., Gualtieri, T., & Ragni, E. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.111.121 · Cited by 142 · see citing works
Salt tolerance (STO), a stress‐related protein, has a major role in light signalling
Indorf, M., Cordero, J., Neuhaus, G., & Rodríguez‐Franco, M. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03162.x · Cited by 140 · see citing works
Increasing complexity and versatility: How the calcium signaling toolkit was shaped during plant land colonization
Edel, K. H., & Kudla, J. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.10.013 · Cited by 139 · see citing works
Good fungi gone bad: The corruption of calcineurin
Fox, D. S., & Heitman, J. (2002) · BioEssays · doi:10.1002/bies.10157 · Cited by 137 · see citing works
Differential Regulation of Two Ca2+ Influx Systems by Pheromone Signaling in Saccharomyces cerevisiae
Muller, E. M., Locke, E., & Cunningham, K. W. (2001) · Genetics · doi:10.1093/genetics/159.4.1527 · Cited by 133 · see citing works
From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes
Brunet, T., & Arendt, D. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0043 · Cited by 129 · see citing works
A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, and Saccharomyces cerevisiae
Zelter, A., Benčina, M., Bowman, B. J., Yarden, O., & Read, N. D. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2004.05.001 · Cited by 129 · see citing works
Acidic calcium stores of Saccharomyces cerevisiae
Cunningham, K. W. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.01.010 · Cited by 120 · see citing works
Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites
Prole, D. L., & Taylor, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026218 · Cited by 111 · see citing works
Multiple Signaling Pathways Regulate Yeast Cell Death during the Response to Mating Pheromones
Zhang, N.-N., Dudgeon, D. D., Paliwal, S., Levchenko, A., Grote, E., & Cunningham, K. W. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0177 · Cited by 115 · see citing works
Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling
Edlind, T., Smith, L., Henry, K., Katiyar, S., & Nickels, J. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03165.x · Cited by 114 · see citing works
Fig1p Facilitates Ca2+ Influx and Cell Fusion during Mating of Saccharomyces cerevisiae
Muller, E. M., Mackin, N. A., Erdman, S. E., & Cunningham, K. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304089200 · Cited by 112 · see citing works
An update on receptor-like kinase involvement in the maintenance of plant cell wall integrity
Engelsdorf, T., & Hamann, T. (2014) · Annals of Botany · doi:10.1093/aob/mcu043 · Cited by 103 · see citing works
The Plant Cell Wall Integrity Maintenance Mechanism—Concepts for Organization and Mode of Action
Hamann, T. (2014) · Plant and Cell Physiology · doi:10.1093/pcp/pcu164 · Cited by 100 · see citing works
Functional expression of heterologous proteins in yeast: insights into Ca2+ signaling and Ca2+-transporting ATPases
Ton, V., & Rao, R. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00135.2004 · Cited by 102 · see citing works
INP51, a Yeast Inositol Polyphosphate 5-Phosphatase Required for Phosphatidylinositol 4,5-Bisphosphate Homeostasis and Whose Absence Confers a Cold-resistant Phenotype
Stolz, L. E., Kuo, W. J., Longchamps, J., Sekhon, M. K., & York, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11852 · Cited by 99 · see citing works
Pulses of Ca 2+ coordinate actin assembly and exocytosis for stepwise cell extension
Takeshita, N., Evangelinos, M., Zhou, L., Serizawa, T., Fajardo-Somera, R. A., Lü, L., Takaya, N., Nienhaus, G. U., & Fischer, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700204114 · Cited by 95 · see citing works
Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation
Birchwood, C. J., Saba, J. D., Dickson, R. C., & Cunningham, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010221200 · Cited by 95 · see citing works
New Regulators of a High Affinity Ca2+ Influx System Revealed through a Genome-wide Screen in Yeast
Martin, D. C., Kim, H., Mackin, N. A., Maldonado‐Báez, L., Evangelista, C. C., Beaudry, V. G., Dudgeon, D. D., Naiman, D. Q., Erdman, S. E., & Cunningham, K. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.177451 · Cited by 93 · see citing works
Coordinate responses to alkaline pH stress in budding yeast
Serra‐Cardona, A., Canadell, D., & Ariño, J. (2015) · Microbial Cell · doi:10.15698/mic2015.06.205 · Cited by 91 · see citing works
Cytosolic Ca2+ Homeostasis Is a Constitutive Function of the V-ATPase in Saccharomyces cerevisiae
Förster, C. Y., & Kane, P. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006650200 · Cited by 86 · see citing works
A genomic view of yeast membrane transporters
Belle, D. V., & André, B. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00226-x · Cited by 84 · see citing works
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast
Lanthaler, K., Bilsland, E., Dobson, P. D., Moss, H. J., Pir, P., Kell, D. B., & Oliver, S. G. (2011) · BMC Biology · doi:10.1186/1741-7007-9-70 · Cited by 82 · see citing works
Amiodarone induces a caffeine‐inhibited, MID1‐depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae
Courchesne, W. E., & Ozturk, S. B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03291.x · Cited by 79 · see citing works
The Molecular Biology of Invertebrate Voltage-Gated Ca2+ Channels
Jeziorski, M. C., Greenberg, R. M., & Anderson, P. A. V. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.5.841 · Cited by 78 · see citing works
The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity
Peiter, E., Fischer, M. J. C., Sidaway‐Lee, K., Roberts, S. K., & Sanders, D. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.058 · Cited by 77 · see citing works
Cch1 Mediates Calcium Entry in Cryptococcus neoformans and Is Essential in Low-Calcium Environments
Liu, M., Du, P., Heinrich, G., Cox, G. M., & Gelli, A. (2006) · Eukaryotic Cell · doi:10.1128/ec.00158-06 · Cited by 76 · see citing works
Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways
Kullas, A. L., Martin, S. J., & Davis, D. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05929.x · Cited by 75 · see citing works
Functional analysis of a putative Ca2+ channel gene TaTPC1 from wheat
Wang, Y., Yu, J., Chen, T., Zhang, Z., Hao, Y., Zhang, J., & Chen, S. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri302 · Cited by 68 · see citing works
Avian magnetite-based magnetoreception: a physiologist's perspective
Cadiou, H., & McNaughton, P. A. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0423.focus · Cited by 68 · see citing works
Cell wall integrity modulates Arabidopsis thaliana cell cycle gene expression in a cytokinin- and nitrate reductase-dependent manner
Bisceglia, N. G., Engelsdorf, T., Strnad, M., Vaahtera, L., Khan, G. A., Yamoune, A., Alipanah, L., Novák, O., Persson, S., Hejátko, J., et al. (2018) · Development · doi:10.1242/dev.166678 · Cited by 62 · see citing works
Involvement of the putative Ca2+-permeable mechanosensitive channels, NtMCA1 and NtMCA2, in Ca2+ uptake, Ca2+-dependent cell proliferation and mechanical stress-induced gene expression in tobacco (Nicotiana tabacum) BY-2 cells
Kurusu, T., Yamanaka, T., Nakano, M., Takiguchi, A., Ogasawara, Y., Hayashi, T., Iida, K., Hanamata, S., Shinozaki, K., Iida, H., et al. (2011) · Journal of Plant Research · doi:10.1007/s10265-011-0462-6 · Cited by 66 · see citing works
The plant cell wall integrity maintenance mechanism – A case study of a cell wall plasma membrane signaling network
Hamann, T. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.09.019 · Cited by 65 · see citing works
NSC1: a novel high‐current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae
Bihler, H. J., Slayman, C. L., & Bertl, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00832-1 · Cited by 66 · see citing works
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation
Ongusaha, P. P., Hughes, P., Davey, J. F., & Michell, R. H. (1998) · Biochemical Journal · doi:10.1042/bj3350671 · Cited by 65 · see citing works
Putative Calcium Channels CchA and MidA Play the Important Roles in Conidiation, Hyphal Polarity and Cell Wall Components in Aspergillus nidulans
Wang, S., Cao, J., Liu, X., Hu, H., Shi, J. R., Zhang, S., Keller, N. P., & Lü, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046564 · Cited by 64 · see citing works
Phylogeny Unites Animal Sodium Leak Channels with Fungal Calcium Channels in an Ancient, Voltage-Insensitive Clade
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss182 · Cited by 64 · see citing works
The Involvement of the Mid1/Cch1/Yvc1 Calcium Channels in Aspergillus fumigatus Virulence
de Castro, P. A., Chiaratto, J., Winkelströter, L. K., Bom, V. L. P., Ramalho, L. N. Z., Goldman, M. H. S., Brown, N. A., & Goldman, G. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103957 · Cited by 60 · see citing works
The fungal opsin gene nop-1 is negatively-regulated by a component of the blue light sensing pathway and influences conidiation-specific gene expression in Neurospora crassa
Bieszke, J. A., Li, L., & Borkovich, K. A. (2007) · Current Genetics · doi:10.1007/s00294-007-0148-8 · Cited by 60 · see citing works
Vacuolar H+-ATPase (V-ATPase) Promotes Vacuolar Membrane Permeabilization and Nonapoptotic Death in Stressed Yeast
Kim, H., Kim, A., & Cunningham, K. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363390 · Cited by 60 · see citing works
Fuel Ethanol Production from Sugarcane
Basso, T. P., & Basso, L. C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.74271 · Cited by 57 · see citing works
Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress
Hong, M.-P., Vu, K., Bautos, J., & Gelli, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056218 · Cited by 54 · see citing works
Ion-channel blocker sensitivity of voltage-gated calcium-channel homologue Cch1 in Saccharomyces cerevisiae
Teng, J., Goto, R., Iida, K., Kojima, I., & Iida, H. (2008) · Microbiology · doi:10.1099/mic.0.2008/021089-0 · Cited by 53 · see citing works
Mid1, a Mechanosensitive Calcium Ion Channel, Affects Growth, Development, and Ascospore Discharge in the Filamentous Fungus Gibberella zeae
Cavinder, B., Hamam, A. M., Lew, R. R., & Trail, F. (2011) · Eukaryotic Cell · doi:10.1128/ec.00235-10 · Cited by 53 · see citing works
Functional Analysis of a Rice Putative Voltage-Dependent Ca2+ Channel, OsTPC1, Expressed in Yeast Cells Lacking its Homologous Gene CCH1
Hashimoto, K., Saito, M., Matsuoka, H., Iida, K., & Iida, H. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch053 · Cited by 49 · see citing works
Role of Fig1, a Component of the Low-Affinity Calcium Uptake System, in Growth and Sexual Development of Filamentous Fungi
Cavinder, B., & Trail, F. (2012) · Eukaryotic Cell · doi:10.1128/ec.00007-12 · Cited by 48 · see citing works
Phenotype of a Mechanosensitive Channel Mutant, mid - 1 , in a Filamentous Fungus, Neurospora crassa
Lew, R. R., Abbas, Z., Anderca, M. I., & Free, S. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00411-07 · Cited by 47 · see citing works
Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1
Yoshimura, H., Tada, T., & Iida, H. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.020 · Cited by 45 · see citing works
Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
Bonilla, M., & Cunningham, K. W. (2002) · Science s STKE · doi:10.1126/stke.2002.127.pe17 · Cited by 45 · see citing works
The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo‐osmotic shock in Saccharomyces cerevisiae
Gualtieri, T., Ragni, E., Mizzi, L., Fascio, U., & Popolo, L. (2004) · Yeast · doi:10.1002/yea.1155 · Cited by 45 · see citing works
Evidence for the Role of Calcineurin in Morphogenesis and Calcium Homeostasis during Mycelium-to-Yeast Dimorphism of Paracoccidioides brasiliensis
de Campos, C. B. L., Benedette, J. P. T. D., Morais, F. V., Ovalle, R., & Nóbrega, M. P. (2008) · Eukaryotic Cell · doi:10.1128/ec.00110-08 · Cited by 42 · see citing works
Calcium homeostasis and signaling in fungi and their relevance forpathogenicity of yeasts and filamentous fungi
Tisi, R., Rigamonti, M. M., Groppi, S., & Belotti, F. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.4.505 · Cited by 40 · see citing works
Thigmo Responses: The Fungal Sense of Touch
Almeida, M. C., & Brand, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0040-2016 · Cited by 40 · see citing works
Hexose phosphorylation and the putative calcium channel component Mid1p are required for the hexose‐induced transient elevation of cytosolic calcium response in Saccharomyces cerevisiae
Tökés‐Füzesi, M., Bedwell, D. M., Repa, I., Sipos, K., Sümegi, B., Rab, A., & Miseta, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02956.x · Cited by 40 · see citing works
The Yeast Transcription Factor Crz1 Is Activated by Light in a Ca2+/Calcineurin-Dependent and PKA-Independent Manner
Bodvard, K., Jörhov, A., Blomberg, A., Molin, M., & Käll, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053404 · Cited by 39 · see citing works
Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus
Zhang, Y., Zheng, Q., Sun, C., Song, J., Gao, L., Zhang, S., Muñoz, A., Read, N. D., & Lü, L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005977 · Cited by 39 · see citing works
Identification and Analysis of Cation Channel Homologues in Human Pathogenic Fungi
Prole, D. L., & Taylor, C. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042404 · Cited by 37 · see citing works
Yeast Mn2+ Transporter, Smf1p, Is Regulated by Ubiquitin-Dependent Vacuolar Protein Sorting
Eguez, L., Chung, Y., Kuchibhatla, A., Paidhungat, M., & Garrett, S. (2004) · Genetics · doi:10.1534/genetics.167.1.107 · Cited by 37 · see citing works
Self-citation
Deletion of Mid1, a putative stretch-activated calcium channel in Claviceps purpurea, affects vegetative growth, cell wall synthesis and virulence
Bormann, J., & Tudzynski, P. (2009) · Microbiology · doi:10.1099/mic.0.030825-0 · Cited by 35 · see citing works
Molecular cloning in yeast by in vivo homologous recombination of the yeast putative α1 subunit of the voltage‐gated calcium channel
Iida, K., Tada, T., & Iida, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.021 · Cited by 35 · see citing works
Sexual pheromone modulates the frequency of cytosolic Ca2+bursts inSaccharomyces cerevisiae
Carbó, N., Tarkowski, N., Ipiña, E. P., Dawson, S. P., & Aguilar, P. S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0481 · Cited by 34 · see citing works
The CRaZy Calcium Cycle
Espeso, E. A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-25304-6_7 · Cited by 33 · see citing works
Activation of an Essential Calcium Signaling Pathway in Saccharomyces cerevisiae by Kch1 and Kch2, Putative Low-Affinity Potassium Transporters
Stefan, C. P., Zhang, N., Sokabe, T., Rivetta, A., Slayman, C. L., Montell, C., & Cunningham, K. W. (2013) · Eukaryotic Cell · doi:10.1128/ec.00299-12 · Cited by 32 · see citing works
Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall
Vazquez, H. M., Vionnet, C., Roubaty, C., & Conzelmann, A. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1033 · Cited by 32 · see citing works
Cch1 and Mid1 Are Functionally Required for Vegetative Growth under Low-Calcium Conditions in the Phytopathogenic Ascomycete Botrytis cinerea
Harren, K., & Tudzynski, B. (2013) · Eukaryotic Cell · doi:10.1128/ec.00338-12 · Cited by 31 · see citing works
Ecm7, a regulator of HACS, functions in calcium homeostasis maintenance, oxidative stress response and hyphal development in Candida albicans
Ding, X., Yu, Q., Xu, N., Wang, Y., Cheng, X., Qian, K., Zhao, Q., Zhang, B., Xing, L., & Li, M. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.05.010 · Cited by 30 · see citing works
Antihypertensive, Amlodipine Besilate Inhibits Growth and Biofilm of Human Fungal Pathogen Candida
Gupta, P., Chanda, R., Rai, N., Kataria, V., & Kumar, N. (2016) · Assay and Drug Development Technologies · doi:10.1089/adt.2016.714 · Cited by 30 · see citing works
Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae
Courchesne, W. E., Vlasek, C., Klukovich, R., & Coffee, S. (2011) · Archives of Microbiology · doi:10.1007/s00203-010-0673-6 · Cited by 30 · see citing works

The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating
Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01466-x · Cited by 185 · see citing works
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.
Iida, H., Nakamura, H., Ono, T., Okumura, M. S., & Anraku, Y. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8259 · Cited by 218 · see citing works
A Homolog of Voltage-Gated Ca 2+ Channels Stimulated by Depletion of Secretory Ca 2+ in Yeast
Locke, E. G., Bonilla, M., Liang, L., Takita, Y., & Cunningham, K. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6686-6694.2000 · Cited by 212 · see citing works
Amiodarone induces a caffeine‐inhibited, MID1‐depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae
Courchesne, W. E., & Ozturk, S. B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03291.x · Cited by 79 · see citing works
Genetic analysis of the regulation of the voltage-gated calcium channel homolog Cch1 by the γ subunit homolog Ecm7 and cortical ER protein Scs2 in yeast
Kato, T., Kubo, A., Nagayama, T., Kume, S., Tanaka, C., Nakayama, Y., Iida, K., & Iida, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181436 · Cited by 9 · see citing works

Authors: Paidhungat, M., & Garrett, S.
Affiliations: Duke University (US)
ORCID: Garrett, Stephen
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1997-11
Volume: 17
Issue: 11
Pages: 6339-6347
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.17.11.6339
PMC: PMC232485
OpenAlex: W2162829341
Cited by: 191
References: 40
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 11 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 12
FWCI: 2.02
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: voltage-gated calcium channels, calcium uptake, MID1, mating pheromone signaling, intracellular calcium, lithium tolerance, manganese depletion, salt stress, Saccharomyces cerevisiae
MeSH terms: Amino Acid Sequence, Biological Transport, Calcium, Fungal Proteins, Membrane Glycoproteins, Molecular Sequence Data, Mutation, Pheromones, Saccharomyces cerevisiae, Suppression, Genetic, Calcium Channels, Ion Channel Gating, Gene Expression, Sequence Homology, Amino Acid, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Homolog of Mammalian, Voltage-Gated Calcium Channels Mediates Yeast Pheromone-Stimulated Ca 2+ Uptake and Exacerbates the cdc1 (Ts) Growth Defect

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks