The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Novel repair action of vitamin C upon in vivo oxidative DNA damage
Abstract
There appears to be a paucity of data examining the effect of dietary antioxidants on levels of oxidative DNA damage in vivo, limiting evidence‐based assessment of antioxidant efficacy, mechanisms and recommendation for optimal intake. We have examined levels of 8‐oxo‐2′‐deoxyguanosine (8‐oxodG) in mononuclear cell DNA, serum and urine from subjects undergoing supplementation with 500 mg/day vitamin C. Significant decreases in DNA levels of 8‐oxodG were seen, correlating strongly with increases in plasma vitamin C concentration. Furthermore we established a timecourse for sequential, significant increases in serum and urinary 8‐oxodG levels. These results illustrate, for the first time in humans, the kinetics of 8‐oxodG removal and processing in vivo, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non‐scavenging antioxidant effect.
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Citations
Cites
Vitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800
Self-citationRehman, A., Collis, C. S., Yang, M., Kelly, M., Diplock, A. T., Halliwell, B., & Rice-Evans, C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8592 · Cited by 202
Cited by
Wu, L. L., Chiou, C.-C., Chang, P.-Y., & Wu, J. T. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.010 · Cited by 990
Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020) · Nutrients · doi:10.3390/nu12051501 · Cited by 455
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in Bioscience · doi:10.2741/a831 · Cited by 369
Pawelec, G. (1998) · Frontiers in Bioscience · doi:10.2741/a266 · Cited by 357
Establishing the Significance and Optimal Intake of Dietary Antioxidants: The Biomarker Concept
Halliwell, B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1999.tb06933.x · Cited by 281
Metadata
- Authors
- Cooke, M. S., Evans, M. D., Podmore, I. D., Herbert, K. E., Mistry, N., Mistry, P., Hickenbotham, P. T., Hussieni, A., Griffiths, H. R., & Lunec, J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-11-20
- Volume
- 439
- Issue
- 3
- Pages
- 363-367
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2072528535
- Cited by
- 160
- References
- 2
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cooke, M. S., Evans, M. D., Podmore, I. D., Herbert, K. E., Mistry, N., Mistry, P., Hickenbotham, P. T., Hussieni, A., Griffiths, H. R., & Lunec, J. (1998). Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)01403-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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