The DOI matches its Crossref record; 459 of the 459 references it cites were found in a registry or an index.
T cells and aging
Open accessAbstract
Deterioration of the immune system with aging ("immunosenescence") is believed to contribute to morbidity and mortality in man due to the greater incidence of infection, as well as possibly autoimmune phenomena and cancer in the aged. Dysregulation of T cell function is thought to play a critical part in these processes. Factors contributing to T cell immunosenescence may include a) stem cell defects, b) thymus involution, c) defects in antigen presenting cells (APC), d) aging of resting immune cells, e) disrupted activation pathways in immune cells, f) replicative senescence of clonally expanding cells. This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence.
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Cites
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Cited by
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567
Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade
Sutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S., Blazar, B. R., Millar, J. L., Malin, M. A., Chidgey, A. P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2741 · Cited by 486
Immunology of aging: the birth of inflammaging
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Self-citationInnate immunity and inflammation in ageing: a key for understanding age-related diseases
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Metadata
- Authors
- Pawelec, G.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 1998
- Volume
- 3
- Issue
- 4
- Pages
- d59-99
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/a266
- OpenAlex
- W2336942609
- Cited by
- 357
- References
- 459
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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