Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

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Fundamentals of Cancer Metabolism

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Iron and cancer: more ore to be mined

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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

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Ascorbic acid: Chemistry, biology and the treatment of cancer

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Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH

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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

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Ascorbate regulation and its neuroprotective role in the brain

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Vitamin C: The known and the unknown and Goldilocks

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Hypoxia and Metabolic Adaptation of Cancer Cells

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Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2

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Body iron metabolism and pathophysiology of iron overload

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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

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The biochemical functions of ascorbic acid

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�ber die Katalyse des Hydroperoxydes

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New developments and novel therapeutic perspectives for vitamin C

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The Haber-Weiss cycle – 70 years later

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High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

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A new recommended dietary allowance of vitamin C for healthy young women

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O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

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5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

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ROS and Brain Diseases: The Good, the Bad, and the Ugly

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Mitochondrial dysfunction in Alzheimer's disease: role in pathogenesis and novel therapeutic opportunities

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Vitamin C Function and Status in Chronic Disease

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Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

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Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial

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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

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DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

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Vitamin C enters mitochondria via facilitative glucose transporter 1 (Gluti) and confers mitochondrial protection against oxidative injury

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New platinum complexes with anti-tumour activity

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Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

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Antioxidant supplements for preventing gastrointestinal cancers

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Dietary vitamin C in human health

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Antioxidant enzymes and cancer

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5-hydroxymethylcytosine and its potential roles in development and cancer

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Targeting cancer stem cells: a new therapy to cure cancer patients.

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Vitamin C Prevents DNA Mutation Induced by Oxidative Stress

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Serum Vitamin C Concentration Is Low in Peripheral Arterial Disease and Is Associated With Inflammation and Severity of Atherosclerosis

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Cisplatin-induced gastrointestinal toxicity: An update on possible mechanisms and on available gastroprotective strategies

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Novel repair action of vitamin C upon in vivo oxidative DNA damage

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Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, β-carotene and red ginseng)

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Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

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Effect of oxidative DNA damage in promoter elements on transcription factor binding

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Vitamin C and survival among women with breast cancer: A Meta-analysis

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Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany.

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Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders

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Sailors' scurvy before and after James Lind - a reassessment

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Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β

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High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

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Gene expression profiling reveals new protective roles for vitamin C in human skin cells

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Urinary 8-oxo-2′-deoxyguanosine: redox regulation of DNA repair in vivo?

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Serum Vitamin C Concentration Was Inversely Associated With Subsequent 20-Year Incidence of Stroke in a Japanese Rural Community

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A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genomePreprint

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Relation of Serum Ascorbic Acid to Mortality Among US Adults

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The Complexity of Tobacco and Tobacco Smoke

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High‐affinity sodium–vitamin C co‐transporters (SVCT) expression in embryonic mouse neurons

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Maternal vitamin C regulates reprogramming of DNA methylation and germline development

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The Discovery of Vitamin C

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Vitamin C as a Modulator of the Response to Cancer Therapy

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Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers

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The use of the ascorbic acid as food additive and technical-legal issues

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Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione

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Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage

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Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

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Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

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Ascorbic acid protects neurons from injury induced by glutamate and NMDA

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Systemic Oxidative Stress and Its Relationship with Age and Illness

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Autoschizis: a novel cell death

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Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine

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Protective effect of vitamin C on 8-hydroxy-2′-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients

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TET1 Exerts Its Tumor Suppressor Function by Interacting with p53-EZH2 Pathway in Gastric Cancer

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Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain

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Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells

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Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation

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Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes

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Vitamin C Transporter Gene Polymorphisms, Dietary Vitamin C and Serum Ascorbic Acid

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Vitamin C in synergism with cisplatin induces cell death in cervical cancer cells through altered redox cycling and p53 upregulation

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Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency

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DNA repair phenotype and dietary antioxidant supplementation

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Ultrastructural Aspects of Autoschizis: A New Cancer Cell Death Induced by the Synergistic Action of Ascorbate/Menadione on Human Bladder Carcinoma Cells

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Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity

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Relationship between smoking and total antioxidant status, total oxidant status, oxidative stress index, vit C, vit E

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Ionizing Radiation-Induced Cell Death Is Partly Caused by Increase of Mitochondrial Reactive Oxygen Species in Normal Human Fibroblast Cells

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Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review

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Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

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Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

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Human 8-Oxoguanine DNA Glycosylase Suppresses the Oxidative Stress–Induced Apoptosis through a p53-Mediated Signaling Pathway in Human Fibroblasts

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Enhanced antitumor activity of vitamin C via p53 in Cancer cells

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The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development

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Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria

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DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents

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