The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Protection against peroxynitrite
Abstract
Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. Biological protection against peroxynitrite is organized in three categories: prevention, interception, and repair. Prevention is the control of the formation of peroxynitrite precursors, nitric oxide and superoxide. Interception is by direct reaction with peroxynitrite, leading to non‐toxic products. In this regard, organoselenium compounds, metalloporphyrin derivatives, and peroxidases (e.g. glutathione peroxidase and myeloperoxidase) exhibit high second‐order rate constants with peroxynitrite. Ebselen, like glutathione peroxidase, protects in a catalytic fashion utilizing glutathione as reductant in the peroxynitrite reductase reaction. Protection by metalloporphyrins can be maintained through glutathione or ascorbate. Repair processes remove damaged products and restitute intact biomolecules.
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“In addition to proteins, peroxynitrite can directly oxidize reduced glutathione, depleting the antioxidant capacity of the cell (37).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [37]
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Self-citation
Metadata
- Authors
- Arteel, G. E., Briviba, K., & Sies, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Sies, Helmut
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-02-26
- Volume
- 445
- Issue
- 2-3
- Pages
- 226-230
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2027107445
- Cited by
- 305
- References
- 74
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 10
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- peroxynitrite, peroxynitrite scavenging, superoxide, nitric oxide, ebselen, glutathione peroxidase, myeloperoxidase, metalloporphyrins, organoselenium compounds, nitration, nitrosation, oxidative stress, inflammation
- MeSH terms
- Animals, Humans, Nitrates, Molecular Structure, Oxidants
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