The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Protection against peroxynitrite
Abstract
Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. Biological protection against peroxynitrite is organized in three categories: prevention, interception, and repair. Prevention is the control of the formation of peroxynitrite precursors, nitric oxide and superoxide. Interception is by direct reaction with peroxynitrite, leading to non‐toxic products. In this regard, organoselenium compounds, metalloporphyrin derivatives, and peroxidases (e.g. glutathione peroxidase and myeloperoxidase) exhibit high second‐order rate constants with peroxynitrite. Ebselen, like glutathione peroxidase, protects in a catalytic fashion utilizing glutathione as reductant in the peroxynitrite reductase reaction. Protection by metalloporphyrins can be maintained through glutathione or ascorbate. Repair processes remove damaged products and restitute intact biomolecules.
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“In addition to proteins, peroxynitrite can directly oxidize reduced glutathione, depleting the antioxidant capacity of the cell (37).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [37]
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Cites
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Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201
The reaction of NO with superoxide
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Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Self-citationPeroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry
Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122
Peroxynitrite formation from macrophage-derived nitric oxide
Ischiropoulos, H., Zhu, L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90433-w · Cited by 1,099
Methionine residues as endogenous antioxidants in proteins
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- Arteel G.E., 1998, Biol. Chem., 379, 1201
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Cited by
Sorted by citations
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Chemistry of Biologically Important Synthetic Organoselenium Compounds
Mugesh, G., Μοnt, W.-W. D., & Sies, H. (2001) · Chemical Reviews · doi:10.1021/cr000426w · Cited by 1,686
Self-citation
Metadata
- Authors
- Arteel, G. E., Briviba, K., & Sies, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Sies, Helmut
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-02-26
- Volume
- 445
- Issue
- 2-3
- Pages
- 226-230
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2027107445
- Cited by
- 305
- References
- 74
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 10
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- peroxynitrite, peroxynitrite scavenging, superoxide, nitric oxide, ebselen, glutathione peroxidase, myeloperoxidase, metalloporphyrins, organoselenium compounds, nitration, nitrosation, oxidative stress, inflammation
- MeSH terms
- Animals, Humans, Nitrates, Molecular Structure, Oxidants
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