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Absorption and metabolism of cyanidin 3‐O‐β‐D‐glucoside in rats
Open accessAbstract
We have clarified for the first time how cyanidin 3‐O‐β‐D‐glucoside (C3G), which is a potent antioxidant anthocyanin, is absorbed and metabolized in vivo. Rats were orally administered C3G (0.9 mmol/kg body weight), and C3G rapidly appeared in the plasma. However, the aglycon of C3G (cyanidin; Cy) was not detected, although it was present in the jejunum. Protocatechuic acid (PC), which may be produced by degradation of Cy, was present in the plasma and the concentration was 8‐fold higher than that of C3G. These results suggest that plasma PC and C3G may contribute to the antioxidant activity of the plasma. In the liver and kidney, C3G was metabolized to methylated C3G (methyl‐C3G), suggesting that C3G and/or methyl‐C3G act as antioxidants in the tissues.
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Cited by
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Tsuda, T. (2018) · Food & Function · doi:10.1039/c7fo01242j · Cited by 367
Self-citationShih, P.-H., Yeh, C.-T., & Yen, G.-C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071933i · Cited by 334
Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00221-2 · Cited by 319
Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00329-4 · Cited by 312
Metadata
- Authors
- Tsuda, T., Horio, F., & Osawa, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-04-23
- Volume
- 449
- Issue
- 2-3
- Pages
- 179-182
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1986527680
- Cited by
- 355
- References
- 0
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tsuda, T., Horio, F., & Osawa, T. (1999). Absorption and metabolism of cyanidin 3‐O‐β‐D‐glucoside in rats. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)00407-x
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