Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.
Abstract
Although antioxidant systems help control the level of reactive oxygen species they may be overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress components as well as inflammatory mediators may be involved in the pathogenesis of vascular disorders, where localized markers of oxidative damage have been found. In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Polyphenols from both berries were able to localize into endothelial cells subsequently reducing endothelial cells vulnerability to increased oxidative stress at both the membrane and cytosol level. Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. In conclusion, polyphenols isolated from both blueberry and cranberry were able to afford protection to endothelial cells against stressor induced up-regulation of oxidative and inflammatory insults. This may have beneficial actions against the initiation and development of vascular diseases and be a contributing factor in the reduction of age-related deficits in neurological impairments previously reported by us.
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Blueberry and cranberry anthocyanins reduce TNF-α induced upregulation of inflammatory mediators in human microvascular endothelial cells.
“Anthocyanins from berries commonly consumed in the United States, such as blueberries and cranberries, have been reported to reduce TNF-α induced upregulation of inflammatory mediators in human microvascular endothelial cells.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [63]
Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [63]
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531 · see citing works
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329 · see citing works
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · see citing works
Effect of Plant Flavonoids on Immune and Inflammatory Cell Function
Middleton, E. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5335-9_13 · Cited by 735 · see citing works
Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y.-C., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999) · Journal of Natural Products · doi:10.1021/np990184z · Cited by 633 · see citing works
Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase
Cho, H. P., Nakamura, M., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.471 · Cited by 630 · see citing works
Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S. E., & Folts, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.10.1050 · Cited by 573 · see citing works
Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y.-C., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999) · Journal of Natural Products · doi:10.1021/np980501m · Cited by 501 · see citing works
Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 434 · see citing works
Miyazawa, T., Nakagawa, K., Kudo, M., Kayo, M., & Someya, K. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9809582 · Cited by 368 · see citing works
Absorption and metabolism of cyanidin 3‐ O ‐β‐ D ‐glucoside in rats
Tsuda, T., Horio, F., & Osawa, T. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00407-x · Cited by 355 · see citing works
Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00329-4 · Cited by 312 · see citing works
Self-citationFlavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.
Gerritsen, M. E., Carley, W. W., Ranges, G. E., Shen, C. P., Phan, S. A., Ligon, G. F., & Perry, C. A. (1995) · Europe PMC (PubMed Central) · Cited by 305 · see citing works
The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease
Cohen, R. A. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80002-7 · Cited by 284 · see citing works
Absorption and Distribution of Tea Catechin(-)-Epigallocatechin-3-Gallate, in the Rat.
Nakagawa, K., & Miyazawa, T. (1997) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.43.679 · Cited by 255 · see citing works
Transport of Quercetin and Its Glucosides across Human Intestinal Epithelial Caco-2 Cells
Walgren, R. A., Walle, U. K., & Walle, T. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00048-3 · Cited by 249 · see citing works
Anthocyanin content and profile within and among blueberry species
Kalt-Torres, W., McDonald, J. E., Ricker, R. D., & Lu, X. (1999) · Canadian Journal of Plant Science · doi:10.4141/p99-009 · Cited by 160 · see citing works
Fractionation of Phenolic Compounds in Red Wine
Oszmiański, J., Ramos, T., & Bourzeix, M. (1988) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1988.39.3.259 · Cited by 155 · see citing works
Tsuda, T., Horio, F., Kitoh, J., & Osawa, T. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1311 · Cited by 145 · see citing works
Fate of the Flavonoid Quercetin in Human Cell Lines: Chemical Instability and Metabolism
Boulton, D. W., Walle, U. K., & Walle, T. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772367 · Cited by 125 · see citing works
Murase, T., Kume, N., Hase, T., Shibuya, Y., Nishizawa, Y., Tokimitsu, I., & Kita, T. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1412 · Cited by 124 · see citing works
Djoussé, L., Ellison, R. C., McLennan, C. E., Cupples, L. A., Lipinska, I., Tofler, G. H., Gokce, N., & Vita, J. A. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00412-9 · Cited by 115 · see citing works
Database of biologically active peptide sequences
Dziuba, J., Mińkiewicz, P., Nałȩcz, D., & Iwaniak, A. (1999) · Food / Nahrung · doi:10.1002/(sici)1521-3803(19990601)43:3 · Cited by 114 · see citing works
Dubey, R. K., Tyurina, Y. Y., Tyurin, V. A., Gillespie, D. G., Branch, R. A., Jackson, E. K., & Kagan, V. E. (1999) · Circulation Research · doi:10.1161/01.res.84.2.229 · Cited by 102 · see citing works
Stefan Zahler, A., Kupatt, C., & Becker, B. F. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.3.555 · Cited by 86 · see citing works
Adaptive Responses of the Endothelium to Stress
Pohlman, T. H., & Harlan, J. M. (2000) · Journal of Surgical Research · doi:10.1006/jsre.1999.5801 · Cited by 84 · see citing works
Virgili, F., Kim, D., & Packer, L. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00778-9 · Cited by 73 · see citing works
Tsai, S.-H., Liang, Y., Lin‐Shiau, S., & Lin, J.-K. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990915)74:4 · Cited by 70 · see citing works
Emerging Noninvasive Biochemical Measures to Predict Cardiovascular Risk
Pahor, M., Elam, M. B., Garrison, R. J., Kritchevsky, S. B., & Applegate, W. B. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.3.237 · Cited by 68 · see citing works
KANEKO, T., & Baba, N. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.323 · Cited by 58 · see citing works
Potential effects of flavonoids on the etiology of vascular disease
Schramm, D. D., & German, J. B. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00051-5 · Cited by 58 · see citing works
Ginseng improves strategic learning by normal and brain-damaged rats
Zhao, R., & McDaniel, W. F. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00066 · Cited by 56 · see citing works
Red Wine Inhibits the Cell-Mediated Oxidation of LDL and HDL
Rifici, V. A., Stephan, E. M., Schneider, S. H., & Khachadurian, A. K. (1999) · Journal of the American College of Nutrition · doi:10.1080/07315724.1999.10718841 · Cited by 51 · see citing works
Cytokine-Induced Inflammation in the Central Nervous System Revisited
Martiney, J. A., Cuff, C. A., Litwak, M. S., Berman, J. W., & Brosnan, C. F. (1998) · Neurochemical Research · doi:10.1023/a:1022457500700 · Cited by 50 · see citing works
Transepithelial transport and accumulation of flavone in human intestinal CACO-2 cells
Kuo, S. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00521-9 · Cited by 30 · see citing works
Lenne-Gouverneur, A. A.-F. (1999) · Molecular Membrane Biology · doi:10.1080/096876899294616 · Cited by 27 · see citing works
Aortic endothelial cells damaged by a nitric oxide donor and protected by flavonoids
Law, A., Wu, J., Zeng, L.-H., & Wu, T.-W. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00118-6 · Cited by 18 · see citing works
[12] Analysis of antioxidant wine polyphenols by high-performance liquid chromatography
Goldberg, D. M., & Soleas, G. J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)99015-8 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081 · see citing works
Effects of supplemental light quality on growth and phytochemicals of baby leaf lettuce
Li, Q., & Kubota, C. (2009) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2009.06.011 · Cited by 948 · see citing works
Lin, J., & Tang, C.-Y. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.01.014 · Cited by 929 · see citing works
Williamson, G., Kay, C. D., & Crozier, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12351 · Cited by 607 · see citing works
Interaction between flavonoids and the blood–brain barrier: <i>in vitro</i> studies
Youdim, K. A., Dobbie, M. S., Kuhnle, G., Proteggente, A. R., Abbott, N. J., & Rice‐Evans, C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01652.x · Cited by 578 · see citing works
Self-citationNon-thermal stabilization mechanisms of anthocyanins in model and food systems—An overview
Cavalcanti, R. N., dos Santos, D. T., & Meireles, M. A. A. (2010) · Food Research International · doi:10.1016/j.foodres.2010.12.007 · Cited by 553 · see citing works
Bian, Z. H., Yang, Q. C., & Liu, W. K. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6789 · Cited by 474 · see citing works
Anthocyanins in Cardiovascular Disease
Wallace, T. C. (2011) · Advances in Nutrition · doi:10.3945/an.110.000042 · Cited by 474 · see citing works
Bacterial pigments and their applications
Venil, C. K., Zakaria, Z. A., & Ahmad, W. A. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.06.006 · Cited by 465 · see citing works
Anthocyanins and Human Health: An In Vitro Investigative Approach
Lila, M. A. (2004) · BioMed Research International · doi:10.1155/s111072430440401x · Cited by 464 · see citing works
“Further investigations by this laboratory team demonstrated that anthocyanins (in particular, cyanidin-3-sambubioside-5-glucoside and cyanidin3, 5-diglucoside) were highly bioavailable in endothelial cells, which was linked to their roles in prevention of atherosclerosis and neurodegenerative disorders [34, 41].”
BackgroundBerries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases
Neto, C. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600279 · Cited by 460 · see citing works
“Some of the observed effects of cranberry linked to the prevention of oxidative processes include reduced lipoprotein oxidation [4, 5], and decreased oxidative damage in models of stroke [6] and vascular diseases of aging [7].”
BackgroundAnthocyanins—More Than Nature′s Colours
Konczak, I., & Zhang, W. Y. (2004) · BioMed Research International · doi:10.1155/s1110724304407013 · Cited by 388 · see citing works
Karlsen, A. S., Retterstøl, L., Laake, P., Paur, I., Kjølsrud-Bøhn, S., Sandvik, L., & Blomhoff, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1951 · Cited by 389 · see citing works
Youdim, K. A., Shukitt‐Hale, B., & Joseph, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.002 · Cited by 373 · see citing works
Alvarez-Suarez, J. M., Giampieri, F., Tulipani, S., Casoli, T., Di Stefano, G., González-Paramás, A. M., Santos-Buelga, C., Busco, F., Quiles, J. L., Cordero, M. D., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.11.002 · Cited by 370 · see citing works
“Even if it is difficult to prove categorically that certain foods can affect the decreased risk of CVD, several studies carried out on berry supplementation are encouraging [4–7].”
ResultErdman, J. W., Balentine, D. A., Arab, L., Beecher, G. R., Dwyer, J. T., Folts, J. D., Harnly, J. M., Hollman, P. C. H., Keen, C. L., Mazza, G., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.718s · Cited by 361 · see citing works
“In recent years, numerous studies have shown that anthocyanins display a wide range of biological activities (221,222), including antioxidant (22,223–225), antiinflammatory (226,227), antimicrobial (228), and anticarcinogenic (229– 231) activities; improvement of vision (232,233); induction of apoptosis (230); and neu…”
BackgroundA Review of Pterostilbene Antioxidant Activity and Disease Modification
McCormack, D., & McFadden, D. W. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/575482 · Cited by 340 · see citing works
“Blueberry supplementation was also shown to reduce H 2 O 2 -induced intracellular ROS production in human microvascular endothelial cells (HMVECs) [32].”
BackgroundAnthocyanin Metabolism in Rats and Their Distribution to Digestive Area, Kidney, and Brain
Talavéra, S., Felgines, C., Texier, O., Besson, C., Gil‐Izquierdo, Á., Lamaison, J., & Rémésy, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050145v · Cited by 334 · see citing works
In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants
Conforti, F., Sosa, S., Marrelli, M., Menichini, F., Statti, G. A., Uzunov, D., Tubaro, A., Menichini, F., & Loggia, R. D. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.11.015 · Cited by 316 · see citing works
Cranberries and Their Bioactive Constituents in Human Health
Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris‐Etherton, P. M., Howell, A. B., Manach, C., Ostertag, L. M., Sies, H., Skulas‐Ray, A. C., & Vita, J. A. (2013) · Advances in Nutrition · doi:10.3945/an.113.004473 · Cited by 313 · see citing works
“Cranberry anthocyanins have a similar effect on microvascular endothelial cells and act to blunt expression of intercellular adhesion molecule 1 (ICAM-1) and monocyte chemotaxic protein 1 after exposure to proinflammatory cytokines (115).”
BackgroundDuthie, S. J., Jenkinson, A. M., Crozier, A., Mullen, W., Pirie, L. P., Kyle, J., Yap, L. S., Christen, P., & Duthie, G. G. (2005) · European Journal of Nutrition · doi:10.1007/s00394-005-0572-9 · Cited by 306 · see citing works
Antioxidant phytochemicals against type 2 diabetes
Dembinska-Kiec, A., Mykkänen, O. T., Kieć‐Wilk, B., & Mykkänen, H. M. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450896579x · Cited by 301 · see citing works
Pappas, E. L., & Schaich, K. M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802145377 · Cited by 301 · see citing works
Cranberry and Its Phytochemicals: A Review of In Vitro Anticancer Studies
Neto, C. C. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.186s · Cited by 295 · see citing works
Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01300 · Cited by 293 · see citing works
Phenolic Compounds from Blueberries Can Inhibit Colon Cancer Cell Proliferation and Induce Apoptosis
Yi, W., Fischer, J. G., Krewer, G. W., & Akoh, C. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051333o · Cited by 280 · see citing works
Potential Health Benefits of Berries
Beattie, J., Crozier, A., & Duthie, G. G. (2005) · Current Nutrition & Food Science · doi:10.2174/1573401052953294 · Cited by 279 · see citing works
“Similarly, anthocyanins and hydroxycinnamic acids from blueberry and cranberry protect endothelial cells against TNFα induced inflammatory responses [56].”
BackgroundAnthocyanins and heart health.
Mazza, G. (2007) · PubMed · Cited by 248 · see citing works
World Journal of Pharmaceutical Sciences
(2021) · World Journal of Pharmaceutical Sciences · doi:10.54037/wjps · Cited by 246 · see citing works
Synthetic and natural iron chelators: Therapeutic potential and clinical use
Hatcher, H. C., Singh, R. N., Torti, F. M., & Torti, S. V. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.121 · Cited by 242 · see citing works
Blueberries and Their Anthocyanins: Factors Affecting Biosynthesis and Properties
Routray, W., & Orsat, V. (2011) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2011.00164.x · Cited by 241 · see citing works
Los flavonoides: propiedades y acciones antioxidantes
Martínez‐Flórez, S., González‐Gallego, J., Culebras, J., & Tuñón, J. (2002) · Nutrición Hospitalaria · Cited by 233 · see citing works
Primetta, A. K., Riihinen, K., & Kainulainen, P. S. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072857m · Cited by 229 · see citing works
Antioxidant and anticancer properties of berries
Baby, B., Antony, P., & Vijayan, R. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1329198 · Cited by 227 · see citing works
“Polyphenols from blueberries were reported to reduce increased oxidative stress in endothelial cells at both the membrane and cytosolic level (Youdim et al., 2002).”
BackgroundReview of Functional and Pharmacological Activities of Berries
Головинская, О., & Wang, C. (2021) · Molecules · doi:10.3390/molecules26133904 · Cited by 232 · see citing works
“Blueberry extracts are able to completely inhibit the proliferation of several tumor cell lines in vitro including the colon (HT-29 and HCT116), prostate (LNCaP), breast, mouth (KB and CAL-27), cervix (HeLa), ovaries (A2780), and skin (B16F10) [107].”
BackgroundAnthocyanins Are Efficiently Absorbed from the Small Intestine in Rats
Talavéra, S., Felgines, C., Texier, O., Besson, C., Manach, C., Lamaison, J., & Rémésy, C. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2275 · Cited by 218 · see citing works
Goyarzu, P., Malin, D. H., Lau, F. C., Taglialatela, G., Moon, W. D., Jennings, R., Moy, E., Moy, D. M., Lippold, S., Shukitt‐Hale, B., et al. (2004) · Nutritional Neuroscience · doi:10.1080/10284150410001710410 · Cited by 213 · see citing works
“The hypothesized mechanism for the beneficial effects of blueberry supplementation in aged subjects is the antioxidant (Prior et al., 1998) and antiinflammatory (Galli et al., 2002; Youdim et al., 2002) activity of the blueberry extract.”
BackgroundCarazzone, C., Mascherpa, D., Gazzani, G., & Papetti, A. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.11.060 · Cited by 208 · see citing works
Anti-inflammatory properties of dietary flavonoids.
González‐Gallego, J., Sánchez‐Campos, S., & Tuñón, M. J. (2007) · PubMed · Cited by 200 · see citing works
Comparison of HPLC Methods for Determination of Anthocyanins and Anthocyanidins in Bilberry Extracts
Zhang, Z., Kou, X., Fugal, K. B., & McLaughlin, J. L. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034596w · Cited by 200 · see citing works
Protective Effects of Anthocyanins from Blackberry in a Rat Model of Acute Lung Inflammation
Rossi, A., Serraino, I., Dugo, P., Paola, R. D., Mondello, L., Genovese, T., Morabito, D., Dugo, G., Sautebin, L., Caputi, A. P., et al. (2003) · Free Radical Research · doi:10.1080/1071576031000112690 · Cited by 196 · see citing works
“Phenolic compounds, which are widely distributed in plants, were considered to play an important role as dietary antioxidants for the prevention of oxidative damage in living systems.([40]) Anthocya-”
BackgroundExtraction and characterization of some natural plant pigments
Boo, H.-O., Hwang, S., Bae, C., Park, S., Heo, B., & Gorinstein, S. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.02.042 · Cited by 192 · see citing works
Nwafor, I. C., Shale, K., & Achilonu, M. C. (2017) · The Scientific World JOURNAL · doi:10.1155/2017/7343928 · Cited by 183 · see citing works
Absorption of Anthocyanins from Blueberry Extracts by Caco-2 Human Intestinal Cell Monolayers
Yi, W., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0531959 · Cited by 177 · see citing works
Conforti, F., Sosa, S., Marrelli, M., Menichini, F., Statti, G. A., Uzunov, D., Tubaro, A., & Menichini, F. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.06.013 · Cited by 174 · see citing works
Kurilich, A. C., Clevidence, B. A., Britz, S. J., Simon, P. W., & Novotny, J. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050570o · Cited by 173 · see citing works
Ahmed, S., Wang, N., Hafeez, B. B., Cheruvu, V. K., & Haqqi, T. M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.9.2096 · Cited by 170 · see citing works
“In a comparative analysis, anthocyanins from pomegranate fruit were shown to possess higher antioxidant activity than vitamin E (α-tocopherol), ascorbic acid, and β-carotene (19).”
BackgroundGarcia-Alonso, M., Minihane, A. M., Rimbach, G. H., Rivas-Gonzalo, J. C., & de Pascual‐Teresa, S. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.011 · Cited by 163 · see citing works
“effect on MCP-1 secretion in different endothelial cell models [7, 19-20].”
BackgroundCharacterisation of anthocyanins in the black soybean (Glycine max L.) by HPLC-DAD-ESI/MS analysis
Lee, J. H., Kang, N. S., Shin, S., Shin, S.-H., Lim, S.-G., Suh, D.-Y., Baek, I.-Y., Park, K.-Y., & Ha, T. J. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.05.056 · Cited by 162 · see citing works
“In addition, these pigments may reduce the risk of coronary heart disease through modulation of arterial protection (Colantuoni, Bertuglia, Magistetti, & Donato, 1991), inhibition of platelet aggregation (Morazzoni & Magistretti, 1990) or endothelial protection (Youdim et al., 2002).”
BackgroundMcLeay, Y., Barnes, M. J., Mündel, T., Hurst, S. M., Hurst, R. D., & Stannard, S. R. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-19 · Cited by 160 · see citing works
“Blueberry fruit exhibit a high antioxidant capacity (oxygen radical absorption capacity - ORAC) and have been shown to reduce oxidative stress and inflammation [15,16] indicating that blueberry-derived anthocyanins may modulate cellular events independent of the fruit’s inherent antioxidant capacity [17-20].”
Lipophilic and Hydrophilic Antioxidants and Their Antioxidant Activities in Purple Rice Bran
Jang, S., & Xu, Z. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803113c · Cited by 157 · see citing works
Asgary, S., Kelishadi, R., Rafieian‐Kopaei, M., Najafi, S., Najafi, M., & Sahebkar, A. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0693-5 · Cited by 157 · see citing works
“proinflammatory response that usually underlies the process of atheromatous lesion formation [5, 42].”
BackgroundPotential Oral Health Benefits of Cranberry
Bodet, C., Grenier, D., Chandad, F., Ofek, I., Steinberg, D., & Weiss, E. I. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701636211 · Cited by 154 · see citing works
dos Santos, D. T., Albarelli, J. Q., Beppu, M. M., & Meireles, M. A. A. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.019 · Cited by 153 · see citing works
Santhakumar, A. B., Bulmer, A. C., & Singh, I. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12177 · Cited by 153 · see citing works
Juríková, T., Škrovánková, S., Mlček, J., Balla, Š., & Snopek, L. (2018) · Molecules · doi:10.3390/molecules24010024 · Cited by 153 · see citing works
“Cranberry fruits inhibit oxidative processes including oxidation of low-density lipoproteins [63], and oxidative and inflammatory damage to the vascular endothelium [64].”
BackgroundCharron, C. S., Clevidence, B. A., Britz, S. J., & Novotny, J. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0710736 · Cited by 153 · see citing works
Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells
Bornšek, Š. M., Žiberna, L., Polak, T., Vanzo, A., Ulrih, N. P., Abram, V., Tramer, F., & Passamonti, S. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.03.092 · Cited by 151 · see citing works
Huang, H., Chen, G., Liao, D., Zhu, Y., & Xue, X. (2016) · Scientific Reports · doi:10.1038/srep23625 · Cited by 149 · see citing works
Tian, Q., Giusti, M. M., Stoner, G. D., & Schwartz, S. J. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.036 · Cited by 148 · see citing works
McAnulty, L. S., Nieman, D. C., Dumke, C. L., Shooter, L. A., Henson, D. A., Utter, A. C., Milne, G., & McAnulty, S. R. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-120 · Cited by 145 · see citing works
Study of Anticancer Activities of Muscadine Grape Phenolics in Vitro
Yi, W., Fischer, J. G., & Akoh, C. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0515328 · Cited by 144 · see citing works
Cranberries (Vaccinium macrocarpon) and Cardiovascular Disease Risk Factors
McKay, D. L., & Blumberg, J. B. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00273.x · Cited by 142 · see citing works
“For example, Youdim et al.(80) found treatment of human microvascular endothelial cells with either cranberry anthocyanins (0.”
BackgroundInfluentialShukla, M., Gupta, K., Rasheed, Z., Khan, K. A., & Haqqi, T. M. (2008) · Journal of Inflammation · doi:10.1186/1476-9255-5-9 · Cited by 141 · see citing works
“Anthocyanins were shown to be effective inhibitors of lipid peroxidation, the production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activity in different model systems [22-24].”
BackgroundFlavonoids in Human Health: From Structure to Biological Activity
Atmani, D., Chaher, N., Atmani-Kilani, D., Berboucha, M., Debbache-Benaida, N., & Boudaoud, H. (2009) · Current Nutrition & Food Science · doi:10.2174/157340109790218049 · Cited by 138 · see citing works
“Early investigations have led to the conclusion that cranberry extracts inhibit LDL oxidation [113], oxidative damage to neurons [114] and oxidative damage of the vascular endothelium [115].”
BackgroundTherapeutic applications of bacterial pigments: a review of current status and future opportunities
Numan, M., Bashir, S., Mumtaz, R., Tayyab, S., Rehman, N. U., Khan, A. L., Shinwari, Z. K., & Al‐Harrasi, A. (2018) · 3 Biotech · doi:10.1007/s13205-018-1227-x · Cited by 139 · see citing works
Characterization of Blackberry Extract and Its Antiproliferative and Anti-Inflammatory Properties
Dai, J., Patel, J. D., & Mumper, R. J. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.238 · Cited by 137 · see citing works
“24 To our knowledge, there have been few or no studies assessing the anti-inflammatory effects of anthocyanin-containing extracts on DCs. DCs are potent antigen-presenting cells and function as initiators and modulators of the immune response.”
Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis
Devareddy, L., Hooshmand, S., Collins, J. K., Lucas, E. A., Chai, S. C., & Arjmandi, B. H. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.09.004 · Cited by 136 · see citing works
“A study conducted at Tufts University found that anthocyanins from blueberry show antioxidative and anti-inflammatory properties in treating human microvascular endothelial cells [36].”
BackgroundClifton, P. M. (2004) · BioMed Research International · doi:10.1155/s1110724304403088 · Cited by 132 · see citing works
“Polyphenols from blue and red berries reduce adhesion molecules in endothelial cells in vitro [35].”
BackgroundPolyphenolic Composition and Antioxidant Capacity of Extruded Cranberry Pomace
White, B. L., Howard, L. R., & Prior, R. L. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902838b · Cited by 132 · see citing works
García-Alonso, M., Rimbach, G. H., Rivas-Gonzalo, J. C., & de Pascual‐Teresa, S. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035360v · Cited by 130 · see citing works
Sweeney, M. I., Kalt-Torres, W., MacKinnon, S. L., Ashby, J., & Gottschall‐Pass, K. T. (2002) · Nutritional Neuroscience · doi:10.1080/1028415021000055970 · Cited by 129 · see citing works
“, 2000a) and endothelial cells (Youdim et al., 2002) exposed to hydrogen peroxide, a form of oxidative stress.”
BackgroundMetzger, B. T., Barnes, D. M., & Reed, J. D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073494t · Cited by 125 · see citing works
The bioavailability of raspberry anthocyanins and ellagitannins in rats
Borges, G., Roowi, S., Rouanet, J., Duthie, G. G., Lean, M. E. J., & Crozier, A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700024 · Cited by 124 · see citing works
Spinardi, A., Cola, G., Gardana, C. S., & Mignani, I. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01045 · Cited by 117 · see citing works
Srivastava, A., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062915o · Cited by 122 · see citing works
Phenolic Compounds: A Good Choice Against Chronic Degenerative Diseases
Luna-Guevara, M. L., Guevara, J. J. L., Hernández‐Carranza, P., Ruiz-Espinosa, H., & Ochoa‐Velasco, C. E. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64179-3.00003-7 · Cited by 123 · see citing works
Anticancer activities of cranberry phytochemicals: An update
Neto, C. C., Amoroso, J., & Liberty, A. M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700433 · Cited by 119 · see citing works
Shaughnessy, K. S., Boswall, I. A., Scanlan, A. P., Gottschall‐Pass, K. T., & Sweeney, M. I. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.01.001 · Cited by 114 · see citing works
“When BB extracts were placed on human endothelial cells ex vivo, various markers of oxidative stress induced by H2O2 were reduced [30].”
BackgroundBo’, C. D., Riso, P., Campolo, J., Möller, P., Loft, S. H., Klimis‐Zacas, D. J., Brambilla, A., Rizzolo, A., & Porrini, M. (2013) · Nutrition Research · doi:10.1016/j.nutres.2012.12.009 · Cited by 113 · see citing works
Yue, X., & Xu, Z. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00845.x · Cited by 112 · see citing works
Costa, G., Francisco, V., Lopes, M. C., Cruz, M. T., & Batista, M. T. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800672049 · Cited by 113 · see citing works
Osman, N., Adawi, D., Ahrné, S., Jeppsson, B. W., & Molin, G. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.06.001 · Cited by 108 · see citing works
Marcarini, J. C., Tsuboy, M. S. F., Luiz, R. C., Ribeiro, L. R., Hoffmann-Campo, C. B., & Mantovani, M. S. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.03.005 · Cited by 108 · see citing works
Vasileiou, I., Katsargyris, Α., Theocharis, S. E., & Giaginis, C. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.05.018 · Cited by 107 · see citing works
“[37] Youdim KA, McDonald J, Kalt W, Joseph JA.”
BackgroundJi, H., Zhang, H., Li, H., & Li, Y. (2015) · Food and Nutrition Sciences · doi:10.4236/fns.2015.61017 · Cited by 106 · see citing works
“They have proved their excellent bioactivities such as antimutagenic [5] [6], radical scavenging [7], antihyperglycemic [8], hepatoprotective [9] [10], anticancer [11] [12], antioxidant activities [13]-[16], and chemopreventive activities [17] [18].”
BackgroundBerry anthocyanins and their aglycons inhibit monoamine oxidases A and B
Dreiseitel, A., Korte, G., Schreier, P. H., Oehme, A., Locher, S., Domani, M., Hajak, G., & Sand, P. G. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.014 · Cited by 104 · see citing works
Exercise‐induced increases in inflammatory cytokines in muscle and blood of horses
Liburt, N. R., Adams, A. A., Betancourt, A., Horohov, D. W., & McKeever, K. H. (2010) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2010.00275.x · Cited by 104 · see citing works
Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507811986 · Cited by 96 · see citing works
Bo’, C. D., Ciappellano, S., Klimis‐Zacas, D. J., Martini, D., Gardana, C., Riso, P., & Porrini, M. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903472x · Cited by 94 · see citing works
Choudhury, S., Ghosh, S., Mukherjee, S., Gupta, P., Bhattacharya, S., Adhikary, A., & Chattopadhyay, S. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.09.001 · Cited by 90 · see citing works
Dietary strategies to recover from exercise-induced muscle damage
Sousa, M., Teixeira, V. H., & Soares, J. M. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.849662 · Cited by 91 · see citing works
“They have been shown to reduced TNF-a induced up-regulation of inflammatory mediators in human micro-vascular endothelial cells (Youdim et al., 2002), to attenuate inflammatory gene expression in mice (DeFuria et al.”
BackgroundWild Mediterranean Dietary Plants as Inhibitors of Pancreatic Lipase
Conforti, F., Perri, V., Menichini, F., Marrelli, M., Uzunov, D., Statti, G. A., & Menichini, F. (2011) · Phytotherapy Research · doi:10.1002/ptr.3603 · Cited by 88 · see citing works
“Recent studies have focused on health functions of phenolics, including flavonoids from fruit and vegetables (Saleem et al., 2002; You-dim et al., 2002; Qian et al., 2004; Chen et al., 2005, 2006; Soobrattee et al., 2005).”
BackgroundProbiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis
Osman, N., Adawi, D., Ahrné, S., Jeppsson, B. W., & Molin, G. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0174-x · Cited by 88 · see citing works
Evidences of the cardioprotective potential of fruits: The case of cranberries
Ruel, G., & Couillard, C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600286 · Cited by 87 · see citing works
Žiberna, L., Lunder, M., Može, Š., Vanzo, A., Tramer, F., Passamonti, S., & Drevenšek, G. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9091-x · Cited by 87 · see citing works
Potential health benefits of anthocyanins in oxidative stress related disorders
Alam, M. A., Islam, P., Subhan, N., Rahman, M. M., Khan, F., Burrows, G. E., Nahar, L., & Sarker, S. D. (2021) · Phytochemistry Reviews · doi:10.1007/s11101-021-09757-1 · Cited by 86 · see citing works
“…frozen blueberries 94 participants were participated in a randomized, double blind, parallel groups, and placebo-controlled trial Intake of 12.5 g/day orally for 12 to 24 weeks trial Supplementation improved cognition (McNamara et al. 2018) disorders and atherosclerosis (Youdim et al. 2000, 2002).”
MethodInfluentialFree radical scavenging and antibacterial activities of southern Serbian red wines
Radovanović, A., Radovanović, B. C., & Jovančićević, B. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.04.008 · Cited by 81 · see citing works
McAnulty, S. R., McAnulty, L. S., Morrow, J. D., Khardouni, D., Shooter, L., Monk, J., Gross, S., & Brown, V. (2005) · Free Radical Research · doi:10.1080/10715760500306836 · Cited by 80 · see citing works
“shown to attenuate oxidative and inflammatory stress [12] and alleviate some of the detrimental effects associated with ROS production [13,14].”
Background
- Authors
- Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A.
- Affiliations
- Tufts University (US)
- Agriculture and Agri-Food Canada (CA)
- Corresponding author
- Youdim, Kuresh A.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 13
- Issue
- 5
- Pages
- 282-288
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W1868361743
- Cited by
- 319
- References
- 40
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 31 · 2012: 20
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Cranberry Institute
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- dietary flavonoids, blueberry polyphenols, cranberry polyphenols, anthocyanins, hydroxycinnamic acids, microvascular endothelial cells, oxidative stress, TNF-α, inflammation, antioxidant activity, interleukin-8, MCP-1, ICAM-1, vascular disease
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