Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, Claudine; Williamson, Gary; Morand, Christine; Scalbert, Augustin; Rémésy, Christian

doi:10.1093/ajcn/81.1.230s

Cited by 4,219Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

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Manach, Claudine, Williamson, Gary, Morand, Christine, Scalbert, Augustin, Rémésy, Christian·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.230s

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Abstract

Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases is emerging. Bioavailability differs greatly from one polyphenol to another, so that the most abundant polyphenols in our diet are not necessarily those leading to the highest concentrations of active metabolites in target tissues. Mean values for the maximal plasma concentration, the time to reach the maximal plasma concentration, the area under the plasma concentration-time curve, the elimination half-life, and the relative urinary excretion were calculated for 18 major polyphenols. We used data from 97 studies that investigated the kinetics and extent of polyphenol absorption among adults, after ingestion of a single dose of polyphenol provided as pure compound, plant extract, or whole food/beverage. The metabolites present in blood, resulting from digestive and hepatic activity, usually differ from the native compounds. The nature of the known metabolites is described when data are available. The plasma concentrations of total metabolites ranged from 0 to 4 mumol/L with an intake of 50 mg aglycone equivalents, and the relative urinary excretion ranged from 0.3% to 43% of the ingested dose, depending on the polyphenol. Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics. The least well-absorbed polyphenols are the proanthocyanidins, the galloylated tea catechins, and the anthocyanins. Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols.

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Polyphenols, alkylresorcinols, and amino acids have half-lives that do not exceed 24 hours.
“Some of the biomarkers listed in Table 1 have half-lives that do not exceed 24 h [polyphenols, alkylresorcinols, and amino acids (34,35)].”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [34]

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El-Seedi, H. R., El-Said, A. M. A., Khalifa, S. A. M., Göransson, U., Bohlin, L., Borg‐Karlson, A., & Verpoorte, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301807g · Cited by 461 · see citing works

Authors: Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Institut National de la Recherche Agronomique (FR)
Corresponding author: Manach, Claudine
ORCID: Manach, Claudine
Williamson, Gary
Morand, Christine
Scalbert, Augustin
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 230S-242S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.230s
OpenAlex: W2119331100
Cited by: 4,219
References: 162
Citations by year: 2026: 201 · 2025: 170 · 2024: 170 · 2023: 170 · 2022: 189 · 2021: 215 · 2020: 241 · 2019: 216 · 2018: 224 · 2017: 242 · 2016: 235 · 2015: 211 · 2014: 246 · 2013: 257 · 2012: 266
FWCI: 78.00
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: polyphenols, bioavailability, bioefficacy, plasma concentration, urinary excretion, polyphenol metabolism, absorption kinetics, gallic acid, isoflavones, catechins, flavanones, quercetin glucosides, proanthocyanidins, anthocyanins, hydroxycinnamic acids, degenerative disease prevention
MeSH terms: Adult, Anthocyanins, Biological Availability, Female, Flavonoids, Food Analysis, Half-Life, Humans, Intestinal Absorption, Isoflavones, Male, Phenols, Area Under Curve, Polyphenols

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Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

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