Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress
Abstract
The objective of this study was to investigate the ability of endothelial cells (EC) to incorporate anthocyanins and to examine their potential benefits against various oxidative stressors. Endothelial dysfunction has been proposed to play an important role in the initiation and development of vascular disease, with studies having shown that administration of antioxidants improves endothelial function. Elderberry extract contains 4 anthocyanins, which where incorporated into the plasma membrane and cytosol of EC following 4 h incubation at 1 mg.ml(-1). However, incorporation within the cytosol was considerably less than that in the membrane. Uptake within both regions appeared to be structure dependent, with monoglycoside concentrations higher than that of the diglucosides in both compartments. The enrichment of EC with elderberry anthocyanins conferred significant protective effects in EC against the following oxidative stressors: hydrogen peroxide (H(2)O(2)); 2, 2'-azobis(2-amidinopropane) dihydrochloride (AAPH); and FeSO(4)/ascorbic acid (AA). These results show for the first time that vascular EC can incorporate anthocyanins into the membrane and cytosol, conferring significant protective effects against oxidative insult. These findings may have important implications on preserving EC function and preventing the initiation of EC changes associated with vascular diseases.
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Elderberry anthocyanins are incorporated by endothelial cells following a 4-h incubation at a concentration of 1 mg/mL.
“Youdim et al. have reported the incorporation of elderberry anthocyanins by endothelial cells, following a 4-h incubation at a concentration of 1 mg/mL.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
Elderberry anthocyanins significantly decreased cytotoxicity caused by chemical inducers of oxidative stress.
“In addition to the cellular bioavailability, elderberry anthocyanins significantly decreased cytotoxicity caused by chemical inducers of oxidative stress.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
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- Authors
- Youdim, K. A., Martin, A., & Joseph, J. A.
- Affiliations
- Tufts University (US)
- Corresponding author
- Youdim, Kuresh A
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 29
- Issue
- 1
- Pages
- 51-60
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2154801407
- Cited by
- 312
- References
- 65
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 20 · 2016: 10 · 2015: 18 · 2014: 12 · 2013: 22 · 2012: 17
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- endothelial cells, oxidative stress, endothelial dysfunction, diglucosides, hydrogen peroxide, AAPH, iron ascorbate, antioxidant defense, vascular disease
- MeSH terms
- Amidines, Animals, Anthocyanins, Aorta, Ascorbic Acid, Cattle, Cell Division, Cells, Cultured, Endothelium, Vascular, Ferric Compounds, Fruit, Humans, Kinetics, Mitochondria, Plant Extracts, Oxidants, Oxidative Stress
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