Cited by 857Endometriosis Research and TreatmentReproductive System and PregnancyEctopic Pregnancy Diagnosis and Management

The DOI matches its Crossref record; 107 of the 111 references it cites were found in a registry or an index.

Immunobiology of endometriosis

Open access

Lebovic, Dan I, Mueller, Michael D, Taylor, Robert N·2001·Fertility and Sterility

DOI 10.1016/s0015-0282(00)01630-7

Open this paper in CoChat — free account

Abstract

Objective To provide a review of the humoral and cellular immunology of endometriosis and to discuss the rationale for future approaches to diagnosis and treatment.Design Literature survey.Result(s) Defective immunosurveillance in women who are destined to develop endometriosis may allow for the survival of ectopic endometrial tissue. The evidence includes endometrial cell resistance to apoptosis, perhaps through the secretion of proteins that interfere with implant recognition and/or FasL expression by stromal cells, inducing apoptosis of Fas-bearing immune cells. Although the immune response may be defective, aspects of it clearly are enhanced in endometriosis, as is seen by the generalized polyclonal B-cell autoimmune activation and secretion of immune proteins. Several cytokines, chemokines, and growth factors (including vascular growth factors) are increased in women with endometriosis.Conclusion(s) A complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. Proinflammatory proteins from endometriotic lesions and associated immune cells contribute to the enhanced inflammatory reaction associated with endometriosis that subserves the survival of these lesions instead of leading to their demise.

Integrity signals

Registry

Crossref · 10.1016/s0015-0282(00)01630-7

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
Untitled work
(1984) · PubMed · Cited by 997
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis
Shifren, J. L., Tseng, J. F., Zaloudek, C. J., Ryan, I., Meng, Y. G., Ferrara, N., Jaffe, R. B., & Taylor, R. N. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768883 · Cited by 656
Self-citation
The vascular endothelial growth factor family of polypeptides
Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., & Leung, D. W. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470305 · Cited by 641
Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis
Ben-Av, P., Crofford, L. J., Wilder, R. L., & Hla, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00956-a · Cited by 565
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
Brogi, E., Wu, T., Namiki, A., & Isner, J. M. (1994) · Circulation · doi:10.1161/01.cir.90.2.649 · Cited by 553
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
Shweiki, D., Itin, A., Neufeld, G., Gitay-Goren, H., & Keshet, E. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116450 · Cited by 531
Vascular endothelial growth factor (VEGF) in endometriosis
Donnez, J., Smoes, P., Gillerot, S., Casanas-Roux, F., & Nisolle, M. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1686 · Cited by 531
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
McLaren, J. F., Prentice, A., Jones, D. S., Millican, S. A., Müller, K. H., Sharkey, A., & Smith, S. K. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118815 · Cited by 499
Endometriosis and pelvic pain: relation to disease stage and localization
Vercellini, P., Trespidi, L., De Giorgi, O., Cortesi, I., Parazzini, F., & Crosignani, P. G. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58089-3 · Cited by 457
Identification and Localization of Alternately Spliced mRNAs for Vascular Endothelial Growth Factor in Human Uterus and Estrogen Regulation in Endometrial Carcinoma Cell Lines1
Jones, D. S., Sharkey, A., Rajput-Williams, J., Burch, D., Schofield, J. P., Fountain, S. A., Boocock, C. A., & Smith, S. K. (1993) · Biology of Reproduction · doi:10.1095/biolreprod48.5.1120 · Cited by 444
Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium
Oosterlynck, D. J., Cornillie, F. J., Waer, M., Vandeputte, M., & Koninckx, P. R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54414-8 · Cited by 441
Peritoneal fluid cell populations in infertility patients
Haney, A. F., Muscato, J. J., & Weinberg, J. B. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45567-6 · Cited by 336
The biological properties of interleukin-1.
Dinarello, C. A. (1995) · PubMed · Cited by 320
Interleukin‐1: A possible role in the infertility associated with endometriosis
Fakih, H., Baggett, B., & Holtz, G. (1988) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(88)90224-x · Cited by 319
Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist
Simón, C., Francés, A., Piquette, G. N., El-Danasouri, I., Zurawski, G., Dang, W., & Polan, M. L. (1994) · Endocrinology · doi:10.1210/endo.134.2.8299552 · Cited by 315
Increased activation of pelvic macrophages in infertile women with mild endometriosis
Halme, J. K., Becker, S., Hammond, M. G., Raj, M. H. G., & Raj, S. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90720-2 · Cited by 305
Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis
Tseng, J. F., Ryan, I., Milam, T. D., Murai, J. T., Schriock, E. D., LANDERS, D. V., & Taylor, R. N. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772585 · Cited by 291
Self-citation
Morphometric study of the stromal vascularization in peritoneal endometriosis
Nisolle, M., Casanas‐Roux, F., Anaf, V., Mine, J.-M., & Donnez, J. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55823-3 · Cited by 289
Treatment-Independent Pregnancy among Infertile Couples
Collins, J. A., Wrixon, W., Janes, L. B., & Wilson, E. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198311173092001 · Cited by 289
Interleukin-1: a possible role in the infertility associated with endometriosis
Fakih, H., Baggett, B., Holtz, G., Tsang, K.-Y., Lee, J. C., & Williamson, H. O. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49993-0 · Cited by 285
Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery
Eisermann, J., Gast, M. J., Pineda, J. A., Odem, R. R., & Collins, J. L. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60185-1 · Cited by 276
Cytokine-induced production of IFN-beta 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17 beta.
TABIBZADEH, S. S., Santhanam, U., Sehgal, P. B., & May, L. T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.9.3134 · Cited by 261
Is endometriosis an autoimmune disease?
Gleicher, N., El-Roeiy, A., Confino, E., & Friberg, J. (1988) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(88)90292-5 · Cited by 251
Regulation of Extravascular Coagulation by Microvascular Permeability
Dvorak, H. F., Senger, D. R., Dvořàk, A. M., Harvey, V. S., & McDonagh, J. (1985) · Science · doi:10.1126/science.3975602 · Cited by 247
Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis
Khorram, O., Taylor, R. N., Ryan, I. P., Schall, T. J., & LANDERS, D. V. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90433-j · Cited by 244
Self-citation
Immunolocalization and Regulation of the Chemokine RANTES in Human Endometrial and Endometriosis Tissues and Cells
Hornung, D., Ryan, I. P., Chao, V. A., Vigne, J., Schriock, E. D., & Taylor, R. N. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3919 · Cited by 239
Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.
D’Angelo, G., Struman, I., MARTIAL, J. A., & Weiner, R. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6374 · Cited by 226
Vascular endothelial growth factor expression in cycling human endometrium
Torry, D. S., Holt, V. J., KEENAN, J. A., Harris, G. S., Caudle, M. R., & Torry, R. J. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58390-3 · Cited by 225
Is endornetriosis an autoimmune disease
Gleicher, N., El-Roeiy, A., Confino, E., & Friberg, J. (1987) · Obstetrics and Gynecology · Cited by 223
The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program
Arici, A. M., Oral, E., Bükülmez, O., Dulęba, A. J., Olive, D. L., & Jones, E. E. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58162-x · Cited by 219
Autoimmunity to endometrium and ovary in endometriosis.
MATHUR, S. P., Peress, M. R., Williamson, H. O., YOUMANS, C. D., MANEY, S. A., Garvin, A. J., Rust, P. F., & Fudenberg, H. H. (1982) · PubMed Central · Cited by 213
Danazol: Endocrine pharmacology and therapeutic applications
Barbieri, R. L., & Ryan, K. J. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90611-6 · Cited by 208
Endometrial epithelial cells in peritoneal fluid during the early follicular phase
Kruitwagen, R. F. P. M., Poels, L. G., Willemsen, W. N. P., de Ronde, I. J. Y., Jap, P. H. K., & Rolland, R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54119-3 · Cited by 199
ENDOMETRIOSIS
Weed, J. C., & Arquembourg, P. C. (1980) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198009000-00018 · Cited by 191
Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis
Guzick, D. S., Silliman, N. P., Adamson, G. D., Buttram, V. C., Canis, M. J., Malinak, L. R., & Schenken, R. S. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81392-1 · Cited by 187
Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1
Lebovic, D. I., Bentzien, F., Chao, V. A., Garrett, E. N., Meng, Y. G., & Taylor, R. N. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.3.269 · Cited by 184
Self-citation
Physiology: Site and menstrual cycle-dependent expression of proteins of the tumour necrosis factor (TNF) receptor family, and BCL-2 oncoprotein and phase-specific production of TNFα in human endometrium
TABIBZADEH, S. S., Zupi, E., Babaknia, A., Liu, R., Marconi, D., & Romaninï, C. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a135928 · Cited by 167
Autoimmunity to Endometrium and Ovary in Endometriosis
MATHUR, S. P., Peress, M. R., Williamson, H. O., YOUMANS, C. D., MANEY, S. A., Garvin, A. J., Rust, P. F., & Fudenberg, H. H. (1983) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198309000-00022 · Cited by 167
IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis
KEENAN, J. A., Chen, T. T., Chadwell, N. L., Torry, D. S., & Caudle, M. R. (1995) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1995.tb00968.x · Cited by 164
The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates
Dmowski, W. P., Rana, N., Michalowska, J., Friberg, J., Papierniak, C. K., & El-Roeiy, A. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57425-1 · Cited by 161
Peritoneal Cellular Immunity and Endometriosis
Ho, H., Wu, M., & Yang, Y. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00319.x · Cited by 160
Tumor Necrosis Factor-α Messenger Ribonucleic Acid and Protein in Human Endometrium1
Hunt, J. S., Chen, H.-L., Hu, X.-L., & TABIBZADEH, S. S. (1992) · Biology of Reproduction · doi:10.1095/biolreprod47.1.141 · Cited by 160
Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture
Viganò, P. (1998) · Molecular Human Reproduction · doi:10.1093/molehr/4.12.1150 · Cited by 147
ENDOMETRIOSIS
Weed, J. C., & ARQUEMBOURG, P. C. (1980) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198023030-00018 · Cited by 138
Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors.
Verghese, M. W., McConnell, R. T., Strickland, A. B., Gooding, R. C., Stimpson, S. A., Yarnall, D. P., Taylor, J. D., & Furdon, P. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24562-1 · Cited by 136
Peritoneal macrophages and infertility: the association between cell number and pelvic pathology
Olive, D. L., Weinberg, J. B., & Haney, A. F. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49036-9 · Cited by 131
Effect of tumor necrosis factor-α on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system
Zhang, R., Wild, R. A., & Ojago, J. M. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55976-7 · Cited by 124
Endometriosis: abnormal endometrium and dysfunctional immune response
Braun, D. P., & Dmowski, W. P. (1998) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199810000-00003 · Cited by 123
Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease
Mori, H., Sawairi, M., NAKAGAWA, M., Itoh, N., Wada, K., & Tamaya, T. (1991) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1991.tb00972.x · Cited by 117
Angiogenesis and Macrophage Activation in Endometriosis
TAYLOR, R. N., RYAN, S. P., MOORE, E. S., HORNUNG, D., SHIFREN, J. L., & TSENG, J. F. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48540.x · Cited by 113
Self-citation
Dysregulation of interleukin-6 responses in ectopic endometrial stromal cells: correlation with decreased soluble receptor levels in peritoneal fluid of women with endometriosis
Rier, S. E., Zarmakoupis-Zavos, P. N., Hu, X., & Becker, J. L. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714120 · Cited by 111
Immunolocalisation of Vascular Endothelial Growth Factor in Human Endometrium
Li, X. F., Gregory, J. C., & Ahmed, A. (1994) · Growth Factors · doi:10.3109/08977199409011000 · Cited by 111
Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
García-Velasco, J. A. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.7.642 · Cited by 110
Endometriosis and Infertility: New Concepts
Ryan, I. P., & Taylor, R. N. (1997) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199706000-00021 · Cited by 106
Self-citation
Immunosuppressive activity of peritoneal fluid in women with endometriosis.
Oosterlynck, D. J., Meuleman, C., Waer, M., Koninckx, P. R., & Vandeputte, M. (1993) · PubMed · Cited by 103
Elevated interleukin-6 levels in peritoneal fluid of patients with pelvic pathology
Buyalos, R. P., Funari, V. A., Azziz, R., Watson, J. M., & Martı́nez-Maza, O. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55216-9 · Cited by 102
Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis
Hill, J. A., & Anderson, D. J. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90736-9 · Cited by 101
Vectorial Secretion of Vascular Endothelial Growth Factor by Polarized Human Endometrial Epithelial Cells
Hornung, D., Lebovic, D. I., Shifren, J. L., Vigne, J., & Taylor, R. N. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00044-2 · Cited by 94
Self-citation
Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis
Braun, D. P., Gebel, H. M., House, R. V., Rana, N., & Dmowski, W. P. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58325-3 · Cited by 94
Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial
Balasch, J., Creus, M. T., Fábregues, F., Carmona, F., Martínez‐Román, S., Manau, D., & Vanrell, J. A. (1997) · Human Reproduction · doi:10.1093/humrep/12.9.2046 · Cited by 92
Interferon‐Gamma (IFN‐γ) and Interleukin‐6 (IL‐6) in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis
KEENAN, J. A., Chen, T. T., Chadwell, N. L., Torry, D. S., & Caudle, M. R. (1994) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1994.tb01111.x · Cited by 89
Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis
Rier, S. E., Parsons, A. K., & Becker, J. L. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56520-0 · Cited by 88
Suppression of natural killer cell activity by sera from patients with endometriosis
Kanzaki, H., Wang, H.-S., Kariya, M., & Mori, T. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91670-6 · Cited by 87
Expression of interleukin-1 (IL-1) beta messenger ribonucleic acid (mRNA) and IL-1 receptor antagonist mRNA in peritoneal macrophages from patients with endometriosis
Mori, H., Sawairi, M., NAKAGAWA, M., Itoh, N., Wada, K., & Tamaya, T. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54896-1 · Cited by 86
Production and Secretion of Complement Component 3 by Endometriotic Tissue*
Isaacson, K., Coutifaris, C., García, C.-R., & Lyttle, C. R. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-5-1003 · Cited by 83
Immunosuppressive effects of danazol in vitro
Hill, J. A., Barbieri, R. L., & Anderson, D. J. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59408-4 · Cited by 77
Kinetics of Transcription Factors Regulating the RANTES Chemokine Gene Reveal a Developmental Switch in Nuclear Events During T-Lymphocyte Maturation
Ortiz, B. D., Krensky, A. M., & Nelson, P. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.202 · Cited by 76
Cytokines in the peritoneal fluid of patients with endometriosis
Koyama, N., Matsuura, K., & Okamura, H. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90273-y · Cited by 76
Endometriosis-associated pelvic pain: evidence for an association between the stage of disease and a history of chronic pelvic pain
Stovall, D. W., Bowser, L. M., Archer, D. F., & Guzick, D. S. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81468-9 · Cited by 75
Endometrial cell adhesion in an in vitro model using intact amniotic membranes
van der Linden, P. J. Q., de Goeij, A. F. P. M., Dunselman, G. A. J., Erkens, H. W. H., & Evers, J. L. H. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58030-3 · Cited by 72
Expression of tumor necrosis factor-alpha and its mRNA in the endometrial mucosa during the menstrual cycle.
Philippeaux, M.-M., & Piguet, P. F. (1993) · PubMed · Cited by 70
Immunomodulation of Rat Endometriotic Implant Growth and Protein Production
Nothnick, W. B., Curry, T. E., & Vernon, M. W. (1994) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1994.tb00860.x · Cited by 68
Uterus and endometrium: Inhibition of human endometrial stromal cell proliferation by interleukin 6
Zarmakoupis-Zavos, P. N., Rier, S. E., Maroulis, G. B., & Becker, J. L. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136306 · Cited by 68
The expression of vascular endothelial growth factor isoforms in cultured human endometrial stromal cells and its regulation by 17beta- oestradiol
Huang, J.-C., Liu, D. Y., & Dawood, M. Y. (1998) · Molecular Human Reproduction · doi:10.1093/molehr/4.6.603 · Cited by 68
The production of placental protein 14 and interleukin 6 by human endometrial cells in culture
Laird, S. M., Li, T. C., & Bolton, A. E. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138144 · Cited by 67
Antiendometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin.
Moncayo, R., Wilken, J., Wilde, N., Kann, D., & Leidenberger, F. (1990) · PubMed · Cited by 62
Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm for a novel approach to the treatment of endometriosis-associated subfertility
Steinleitner, A., Lambert, H., & Roy, S. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54052-7 · Cited by 60
Stimulation of prostaglandin (PG) F2α and PGE2 release by tumour necrosis factor-α and interleukin-1α in cultured human luteal phase endometrial cells
Chen, D.-B., Yang, Z., Le, S.-P., & Harper, M. J. K. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a135790 · Cited by 57
Endometrial autoantigens eliciting immunoglobulin (Ig)G, IgA, and IgM responses in endometriosis
MATHUR, S. P., Garza, D. E., & Smith, L. F. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53637-1 · Cited by 57
Recurrent Endometriosis
Wheeler, J. M., & Malinak, L. R. (1987) · Contributions to gynecology and obstetrics · doi:10.1159/000414842 · Cited by 57
The production of tumour necrosis factor a (TNF- ) by human endometrial cells in culture
Laird, S. M., Tuckerman, E. M., Saravelos, H. G., & Li, T. C. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019379 · Cited by 55
Endometriosis and pelvic pain
Rock, J. A. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56390-0 · Cited by 55
Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis a rodent model
Steinleitner, A., Lambert, H., Suarez, M., Serpa, N., & Roy, S. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54674-3 · Cited by 55
Production of fibronectin by peritoneal macrophages and concentration of fibronectin in peritoneal fluid from patients with or without endometriosis.
Kauma, S. W., Clark, M. R., White, C., & Halme, J. K. (1988) · PubMed · Cited by 55
Mesothelium Expression of Integrins In Vivo and In Vitro
WITZ, C., Montoya-Rodriguez, I., MILLER, D., Schneider, B., & Schenken, R. S. (1998) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(97)00110-x · Cited by 45
The regulation of immunoglobulin production by B cells in patients with endometriosis
Badawy, S. Z. A., Cuenca, V., Kaufman, L., Stitzel, A., & Thompson, M. W. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60664-7 · Cited by 44
Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility.
Ylikorkala, O., Koskimies, A. I., Laatkainen, T., Tenhunen, A., & Viinikka, L. U. (1984) · PubMed · Cited by 42
The nature of the intraperitoneal exudate associated with infertility: peritoneal fluid and serum lysozyme activity
Olive, D. L., Haney, A. F., & Weinberg, J. B. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59534-x · Cited by 38
Autoantibodies associated with endometriosis: Can their detection predict presence of the disease?
Ra, W., Hirisave, V., Podczaski, E. S., Coulam, C. B., Shivers, C. A., & SATYASWAROOP, P. G. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90768-e · Cited by 33
The Surgical Management of Endometriosis
Wheeler, J. M., & Malinak, L. R. (1989) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00143-1 · Cited by 33
Vascular endothelial growth factor in reproductive biology
Lebovic, D. I., Mueller, M. D., & Taylor, R. N. (1999) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199906000-00004 · Cited by 31
Self-citation
Effect of a baseline ovarian cyst on the outcome of in vitro fertilization–embryo transfer
Segal, S., Shifren, J. L., Isaacson, K., Leykin, L., Chang, Y., Pal, L., & Toth, T. L. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00449-x · Cited by 29
Interleukin-6 and soluble interleukin-6 receptor in peritoneal fluid and serum of patients with endometriosis.
Schroder, W., Gaetje, R., & Baumann, R. (1996) · PubMed · Cited by 27
Mesothelium Expression of Integrins In Vivo and In Vitro
Witz, C. A., Montoya-Rodriguez, I. A., Miller, D. M., et al. (1998) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155769800500207 · Cited by 25
Endometriosis: recurrence and retreatment.
DeCherney, A. H. (1993) · PubMed · Cited by 24
Cul-de-sac fluid in women with endometriosis: fluid volume, protein and prostanoid concentration during the periovulatory period—days 13 to 18
Rezai, N., Ghodgaonkar, R. B., Zacur, H. A., Rock, J. A., & Dubin, N. H. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59285-1 · Cited by 19
Artificial insemination with donor sperm: A review of 108 patients
Yeh, J., & Mm, S. (1988) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(88)90050-1 · Cited by 17
The defense against endometriosis
Evers, J. L. H. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58499-4 · Cited by 16
Endometriosis
Hurst, B. S., & Rock, J. A. (1989) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198905000-00002 · Cited by 13
An elicited intraperitoneal inflammatory response has no effect on the establishment of pregnancy in the mouse
Haney, A. F., Newbold, R. R., & Doty, E. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56712-0 · Cited by 7
Rantes chemokine expression is up-regulated in stromal cells cultured from human endometriosis tissues.
Ryan, I. (1996) · Journal of the Society for Gynecologic Investigation · doi:10.1016/1071-5576(96)82479-8 · Cited by 5
[Artificial insemination with donor sperm].
Swaab (1955) · PubMed · Cited by 2
Artificial Insemination with Donor Sperm
(1979) · Ethics & Medics · doi:10.5840/em19794311 · Cited by 1

Research works printed but not linked: 4

Redwine, 1988, Mülleriosis, J Reprod Med, 33, 915
Wild, 1991, Autoantibodies associated with endometriosis, Obstet Gynecol, 77, 927
Rier, 1995, Dysregulation of interleukin-6 responses in ectopic endometrial stromal cells, J Clin Endocrinol Metab, 80, 1431
Shifren, 1996, Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium, J Clin Endocrinol Metab, 81, 3112

Sorted by citations

Endometriosis
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166
Endometriosis
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations
Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425
Endometriosis
Zondervan, K. T., Becker, C. M., Koga, K., Missmer, S. A., Taylor, R. N., & Viganò, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0008-5 · Cited by 1,257
Self-citation
Endometriosis
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844

See all 857

Authors: Lebovic, D. I., Mueller, M. D., & Taylor, R. N.
Affiliations: University of Michigan (US)
University of California, San Francisco (US)
Corresponding author: Taylor, Robert N
ORCID: Lebovic, Dan I
Mueller, Michael D
Taylor, Robert N
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2001-01
Volume: 75
Issue: 1
Pages: 1-10
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(00)01630-7
OpenAlex: W2017027476
Cited by: 857
References: 111
Citations by year: 2026: 19 · 2025: 34 · 2024: 25 · 2023: 32 · 2022: 30 · 2021: 36 · 2020: 28 · 2019: 26 · 2018: 23 · 2017: 25 · 2016: 34 · 2015: 40 · 2014: 41 · 2013: 39 · 2012: 42
FWCI: 7.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7816 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32hd008517-01)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD037321, F32HD08517, U54 HD37321)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, immune surveillance, apoptosis resistance, Fas ligand, B cell activation, cytokines, chemokines, growth factors, vascular growth factors, inflammation
MeSH terms: Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Pregnancy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Immunobiology of endometriosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks