Endometriosis and pelvic pain: relation to disease stage and localization
Open accessAbstract
Objectives To determine whether prevalence and severity of pain symptoms are related to endometriosis stage and site, with particular reference to deep infiltrating vaginal lesions. Design Systematic assessment of chronic pelvic pain symptoms. Setting University hospital endometriosis center. Patients A total of 244 consecutive symptomatic patients with endometriosis diagnosed at laparoscopy or laparotomy. Interventions Assessment of dysmenorrhea and nonmenstrual pain by means of a 10-point linear analog scale, a 7-point multidimensional rating scale, and a 3-point verbal scale; evaluation of deep dyspareunia with the first and third systems only. Main outcome measures Prevalence and severity of pain symptoms in relation to endometriosis stage and site of lesions. Correlation between revised American Fertility Society score and symptoms severity, as well as between two pain scales to assess dysmenorrhea and nonmenstrual pain. Results Eighty-eight women had stage I and II disease and 156 had stage III and IV disease. Only ovarian endometriosis was present in 108 patients, only peritoneal implants were present in 37, combined ovarian and peritoneal lesions were present in 57, and histologically confirmed vaginal endometriosis was present in 42. The frequency and severity of deep dyspareunia and the frequency of dysmenorrhea were less in patients with only ovarian endometriosis than in those with lesions at other sites. Patients with vaginal endometriosis had a significantly increased risk of deep dyspareunia compared with those whose lesions were at other sites (odds ratio, 2.55; 95% confidence interval, 1.21 to 5.39). Stage per se, independent of lesion site, was not correlated with frequency and severity of dysmenorrhea and nonmenstrual pain. The severity of deep dyspareunia was related inversely to the endometriosis score (Spearman correlation coefficients for linear analog and verbal rating scales, respectively, -0.22 and -0.20). Kendall test by ranks revealed a correlation between linear analog and multidimensional pain scales in the rating of both dysmenorrhea and nonmenstrual pain (respectively, tau-b, 0.59 and tau-b, 0.68). Conclusions Endometriosis stage in the current classification was not related consistently to pain symptoms. The presence of vaginal lesions was associated frequently with severe deep dyspareunia. Dysmenorrhea and nonmenstrual pelvic pain were assessed with equal accuracy by a linear analog and a multidimensional scale.
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Dysmenorrhea occurs less often in women whose only lesions are ovarian endometriomas than in women with lesions in other locations.
“dysmenorrhea is less frequent in women with only ovarian endometriomas compared with other locations”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Vercellini et al., 1996
In well-documented studies, the location and extent of endometriosis lesions correlate poorly with the location or severity of a woman's pain.
“In carefully documented studies, location and extent of lesions bear little relation to location or amount of pain a woman experiences”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Vercellini et al., 1996
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- Authors
- Vercellini, P., Trespidi, L., De Giorgi, O., Cortesi, I., Parazzini, F., & Crosignani, P. G.
- Affiliations
- University of Milan (IT)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 65
- Issue
- 2
- Pages
- 299-304
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2401134385
- Cited by
- 457
- References
- 20
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 8 · 2023: 8 · 2022: 18 · 2021: 16 · 2020: 26 · 2019: 14 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 19 · 2014: 22 · 2013: 21 · 2012: 16
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, chronic pelvic pain, deep dyspareunia, dysmenorrhea, endometriosis stage, endometriosis localization, deep infiltrating endometriosis, vaginal endometriosis, endometrioma, peritoneal implants, pain intensity, pain scales
- MeSH terms
- Adolescent, Adult, Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Middle Aged, Pain Measurement, Severity of Illness Index, Prevalence, Pelvic Pain
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