The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility
Open accessAbstract
Objective To establish whether initial screening characteristics of normogonadotropic anovulatory infertile women can aid in predicting live birth after induction of ovulation with clomiphene citrate (CC).Design Prospective longitudinal single-center study.Setting Specialist academic fertility unit.Patient(s) Two hundred fifty-nine couples with a history of infertility, oligoamenorrhea, and normal follicle-stimulating hormone (FSH) concentrations who have not been previously treated with any ovulation-induction medication.Intervention(s) 50, 100, or 150 mg of oral CC per day, for 5 subsequent days per cycle.Main outcome measure(s) Conception leading to live birth after CC administration.Result(s) After receiving CC, 98 (38%) women conceived, leading to live birth. The cumulative live birth rate within 12 months was 42% for the total study population and 56% for the ovulatory women who had received CC. Factors predicting the chances for live birth included free androgen index (testosterone/sex hormone-binding globulin ratio), body mass index, cycle history (oligomenorrhea versus amenorrhea), and the woman's age.Conclusion(s) It is possible to predict the individual chances of live birth after CC administration using two distinct prediction models combined in a nomogram. Applying this nomogram in the clinic may be a step forward in optimizing the decision-making process in the treatment of normogonadotropic anovulatory infertility. Alternative first line of treatment options could be considered for some women who have limited chances for success.
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“The FAI, but also BMI, cycle history (oligomenorrhoea or amenorrhoea) and mean ovarian volume, were found to be criteria that influence the ovarian response to stimulation with clomiphene citrate medication (Imani et al., 2002;Balen et al., 2016).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Imani et al., 2002
Citations
Cites
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Imani, B., Eijkemans, M. J. C., Velde, E. R. T., Habbema, J. D. F., & Fauser, B. C. J. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4919 · Cited by 281
Self-citationvan Santbrink, E. J. P., Hop, W. C. J., van Dessel, T. J. H. M., de Jong, F. H., & Fauser, B. C. J. M. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57652-3 · Cited by 189
Self-citationvan Santbrink, E. J. P., Hop, W. C. J., & Fauser, B. C. J. M. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)80068-4 · Cited by 187
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(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976
Self-citationThe Practice Committee of the American Society for Reproductive Medicine
Birmingham, A. (2006) · Cited by 1,925
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61345-2 · Cited by 1,360
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802
Metadata
- Authors
- Imani, B., Eijkemans, M. J. C., te Velde, E. R., Habbema, J. D. F., & Fauser, B. C. J. M.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Fauser, Bart C.J.M
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 77
- Issue
- 1
- Pages
- 91-97
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2081208329
- Cited by
- 262
- References
- 27
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 8 · 2020: 10 · 2019: 14 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 4 · 2013: 13 · 2012: 13
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- clomiphene citrate, ovulation induction, oligoamenorrhea, live birth prediction, nomogram, free androgen index, body mass index, age, cumulative live birth rate, treatment decision-making
- MeSH terms
- Abortion, Spontaneous, Amenorrhea, Clomiphene, Ejaculation, Female, Fertility Agents, Female, Follicle Stimulating Hormone, Humans, Infant, Newborn, Infertility, Female, Insulin-Like Growth Factor I, Male, Oligomenorrhea, Ovulation, Ovulation Induction, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Probability, Retrospective Studies, Sperm Count, Odds Ratio, Treatment Outcome, Leptin
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