Cited by 344Hypothalamic control of reproductive hormonesReproductive Health and ContraceptionEstrogen and related hormone effects

Induction of Ovulation with MRL/41: Preliminary Report

Greenblatt, Robert B.·1961·JAMA

Abstract

MRL/41, an analogue of the nonsteroid estrogen, chlorotrianisene, was evaluated in the human female because it was shown to possess pituitary gonadotropin-inhibiting and antifecundity properties in rats. Although structurally related to a hormone-like chemical agent, this compound does not exhibit estrogenic, progestogenic, or androgenic activity in the human. Studies with this drug were initiated primarily because of its potential as an antifertility agent. Contrary to expectations, some unsuspected and interesting biological activities were observed, one of which was the induction of ovulatorytype menses in amenorrheic anovulatory females.

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Crossref · 10.1001/jama.1961.03040410001001

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Authors
Greenblatt, R. B.
Corresponding author
Greenblatt, Robert B.
Venue
JAMA
Published
1961-10-14
Volume
178
Issue
2
Pages
101
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W2068435339
Cited by
343
References
4
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
21.92
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
ovulation induction, amenorrhea, anovulation, antifertility agents, gonadotropin suppression, menstrual induction
MeSH terms
Female, Humans, Ovulation, Stilbenes

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