The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay
Open accessAbstract
Objective To determine the clonal origins of endometriotic lesions using laser capture microdissection and PCR-based HUMARA assay.Design Molecular genetic study of human tissue.Setting Molecular genetics laboratory in an academic setting.Patient(s) Twenty patients with endometriosis. Forty specimens of endometriotic lesions from these patients and one specimen of normal endometrium were analyzed.Intervention(s) Laser capture microdissection was used to harvest epithelial cells from single and multifocal endometrial lesions from paraffin-embedded and frozen tissues, and their clonality was determined with the HUMARA assay.Main outcome measure(s) Polymerase chain reaction-based HUMARA assay of clonality.Result(s) Thirty-eight specimens were polymorphic and thus informative. Most specimens were monoclonal, as determined by the HUMARA assay. In four specimens of multifocal lesions, polyclonality was detected, but upon more refined microdissections and further analyses, we found that each focus was monoclonal individually.Conclusion(s) Previously reported polyclonality is very likely to be attributed to the pooling of multifocal lesions or contamination of normal tissues. These results suggest that endometriotic lesions were monoclonal in origin, and in the case of multifocal lesions, each focus originates monoclonally; hence, different foci have independent origins. The monoclonality of endometriotic lesions suggests that they may carry neoplastic potentials, and the apparent independent origins of multifocal lesions suggest that reconstruction of individual lesion histories may help us to understand the initiation and progression of endometriosis.
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“Endometriosis lesions are clonal, as demonstrated for typical (149), deep (150), and cystic ovarian (151-153) endometriosis.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [149]
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“A strong argument is that deep (174, 175) and cystic (176-178) ovarian endometriosis are consistently found to be clonal in origin.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [175]
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Markowski, D. N., Küpker, W., & BULLERDIEK, J. (2012) · Gynäkologische Endokrinologie · doi:10.1007/s10304-012-0483-9 · Cited by 1
Gargett, C. E., Masuda, H., & Weston, G. C. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch12 · Cited by 1
Guo, S. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch7 · Cited by 1
Malignant Transformation of Endometriosis: Underlying Mechanisms
Mandai, M., Yamaguchi, K. D., Matsumura, N., & Konishi, I. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_15
Endometriosis‐Associated Ovarian Cancer
Garrett, L. A., & Carmen, M. G. D. (2014) · doi:10.1002/9781118655344.ch8
Endometrial Stem Cells and Endometriosis
Ai, J., & Sadroddiny, E. (2012) · InTech eBooks · doi:10.5772/32015
An investigation of basic science and clinical research methodologies to benefit clinical practice
Varma, R. (2009) · University of Birmingham Institutional Research Archive (University of Birmingham)
Clonal analysis of peripheral papilloma and cancerous cells of the breast
Yu, Q., Niu, Y., Yu, Y., Ding, X., & Shi, Y. (2007) · Chinese Journal of Clinical Oncology · doi:10.1007/s11805-007-0401-4
Clinical Applications of Stem Cells in Women’s Reproductive Health
Mousa, N. A., Shazly, S. A., & Nassr, A. A. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-29149-9_6
Reply: Possible treatment associated cancer in endometriosis
Guo, S. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa024
Endometriosis Research: From Bench to Bedside
Laganà, A. S., & La Rosa, V. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-2798-7
Rasnick, D. (2012) · CRC Press eBooks · doi:10.1201/b11665-10
Porcayo, M. A. T., del Castillo, V. T. G., & del Castillo, A. C. T. G. (2026) · Springer eBooks · doi:10.1007/978-3-032-13454-7_36
Metadata
- Authors
- Wu, Y., Basir, Z., Kajdacsy-Balla, A., Strawn, E., Macias, V., Montgomery, K., & Guo, S.-W.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Guo, Sun-Wei
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 79
- Pages
- 710-717
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2048646241
- Cited by
- 114
- References
- 30
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 9
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical College of Wisconsin
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, endometriotic lesions, clonal origin, monoclonality, polyclonality, multifocal lesions, HUMARA assay, human androgen receptor, laser capture microdissection, endometrial epithelium, neoplastic potential
- MeSH terms
- Adult, Clone Cells, DNA, Neoplasm, Endometriosis, Epithelial Cells, Female, Histocytochemistry, Humans, Lasers, Micromanipulation, Middle Aged, Receptors, Androgen, DNA-Cytosine Methylases, Polymerase Chain Reaction, Sequence Analysis, DNA
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