The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
The climacteric ovary as a functional gonadotropin-driven androgen-producing gland.
Open accessAbstract
Objective To assess the hypothesis that the climacteric ovary is a functional endocrine gland.Design Review of the English-speaking literature as it relates to the physiology and pathophysiology of the climacteric ovary.Results By several accounts, the climacteric ovary appears to be a gonadotropin-dependent androgen-producing gland. Although the estrogen-producing potential of the climacteric ovary remains a matter of controversy, most studies would suggest limited aromatase activity.Conclusions [1] The climacteric ovary is not a defunct endocrine organ. [2] The climacteric ovary is a site of gonadotropin reception and action. [3] The climacteric ovary contributes few if any estrogens to the circulating pool by way of direct production. [4] Circulating estrogens are derived virtually exclusively from the extraglandular conversion of androgens, a proportion of which are of ovarian origin. [5] The climacteric ovary contributes 40% and 20% of the total production rates of T and androstenedione, respectively. [6] Androgen biosynthesis by the climacteric ovary is partially gonadotropin-dependent.
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“It is well recognized that the postmenopausal ovary is a steroid-secreting gland (145, 146).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [145]
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Research works printed but not linked: 1
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Estrogen and cognitive functioning in women
Sherwin, B. B. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0016 · Cited by 560
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
Kaaks, R., Rinaldi, S., Key, T. J., Berrino, F., Peeters, P. H. M., Biessy, C., Dossus, L., Lukanova, A., Bingham, S. A., Khaw, K., et al. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01038 · Cited by 532
Laughlin, G. A., Barrett-Connor, E. L., Kritz‐Silverstein, D. C., & von Mühlen, D. G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6405 · Cited by 381
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Köstner, K., Denzer, N., Müller, F. M., Klein, R., Tilgen, W., & Reichrath, J. (2009) · PubMed · Cited by 337
Metadata
- Authors
- Adashi, E. Y.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Adashi, Eli Y.
- ORCID
- Adashi, Eli Y.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 62
- Issue
- 1
- Pages
- 20-27
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2417679673
- Cited by
- 214
- References
- 69
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Update notices
- erratum (1995-03-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- ovarian androgen production, aromatase activity, estrogen synthesis, androstenedione, testosterone, ovarian endocrine function, menopause
- MeSH terms
- Androgens, Climacteric, Estrogens, Female, Gonadotropins, Humans, Ovary, Receptors, Gonadotropin
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