The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Alcohol and caffeine consumption and decreased fertility
Open accessAbstract
OBJECTIVE: To examine the effects of alcohol and caffeine on conception. DESIGN: Prospective observational study. SETTING: Healthy volunteers in two manufacturing facilities. PATIENT(S): One hundred twenty-four women who provided daily urine samples for measurement of steroid hormones and hCG, and prospective information about alcohol and caffeine consumption. MAIN OUTCOME MEASURE(S): Probability of conception per 100 menstrual cycles. RESULT(S): There was >50% reduction in the probability of conception during a menstrual cycle during which participants consumed alcohol. Caffeine consumption did not independently affect the probability of conception but may enhance alcohol's negative effect. Women who abstained from alcohol and consumed less than one cup of coffee or its equivalent per day conceived 26.9 pregnancies per 100 menstrual cycles compared with 10.5 per 100 menstrual cycles among those who consumed any alcohol and more than one cup of coffee per day. CONCLUSIONS: This study revealed an independent dose-related negative effect of alcohol consumption on the ability to conceive. Our results suggest that women who are attempting to conceive should abstain from consuming alcohol.
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“Consuming high levels of alcohol (> 2 drinks per day, with 1 drink > 10 g of ethanol) can affect both female and male fertility and the success of fertility treatment (Hakim 1998, Klonoff-Cohen 2003, Rossi 2011).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Hakim 1998
Citations
Cites
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Bu, F.-L., Feng, X., Yang, X.-Y., Ren, J., & Cao, H.-J. (2020) · Figshare · doi:10.6084/m9.figshare.12495320
Zhang, H., Qian, S., Chen, J., & Chen, J. (2024) · Figshare · doi:10.6084/m9.figshare.26420341
Ethanol-induced NINJ1 oligomerization might contribute to the lytic death of granulosa cells in PCOS
Berkel, Ç. (2026) · Human Cell · doi:10.1007/s13577-026-01378-0
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Umwelt und Lebensstil — Determinanten des Endokriniums und reproduktiver Funktionen
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Metadata
- Authors
- Hakim, R. B., Gray, R. H., & Zacur, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Hakim, Rosemarie B
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 70
- Issue
- 4
- Pages
- 632-637
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2029365618
- Cited by
- 205
- References
- 39
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 59 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 13 · 2015: 11 · 2014: 4 · 2013: 10 · 2012: 8
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30hd006268-28)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5-P30-HD06268)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- alcohol consumption, caffeine consumption, coffee, female fertility, conception probability, menstrual cycle, dose-response relationship, women of reproductive age, human chorionic gonadotropin, steroid hormones
- MeSH terms
- Adult, Alcohol Drinking, Caffeine, Female, Fertility, Humans, Prospective Studies
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