The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome
Open accessAbstract
Background & aims This study evaluated the effects of a partial 5-hydroxytryptamine (5-HT)(4) agonist, tegaserod, on gastric small bowel and colonic transit in constipation-predominant irritable bowel syndrome (IBS).Methods After a 1 week run-in period, 24 patients with constipation-predominant IBS were randomized to 1 week of tegaserod, 2 mg twice daily, or placebo treatment. Scintigraphic gastric emptying, small bowel transit, and colonic transit were determined before administration of study drug and after 1 week on the medication. Colonic transit was also measured using radiopaque markers and a single radiograph on day 5.Results Gastric emptying was unaltered by tegaserod. Proximal colonic filling at 6 hours, a measure of orocecal transit, was accelerated by tegaserod (70.4% +/- 1.3% [mean +/- SEM] vs. placebo, 46.4 +/- 1.9; P = 0.015). Proximal colonic emptying half-time and geometric center at 48 hours were also accelerated by tegaserod compared with baseline, but not compared with placebo. Mean colonic transit time was similar in both groups at baseline and after drug administration (tegaserod, 59.5 +/- 2.1 hours; placebo, 62.1 +/- 2.1 hours).Conclusions Tegaserod accelerates orocecal transit, tends to accelerate colonic transit, and deserves further study in patients with constipation-predominant IBS.
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Orocaecal transit accelerated by tegaserod
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Metadata
- Authors
- Prather, C. M., Camilleri, M., Zinsmeister, A. R., McKinzie, S., & Thomforde, G.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Camilleri, Michael
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 118
- Issue
- 3
- Pages
- 463-468
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2095055104
- Cited by
- 410
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 36.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02638-01, K24DK002638, R01-DK546881)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Keywords
- tegaserod, irritable bowel syndrome with constipation, orocecal transit, colonic transit, gastric emptying, small intestinal transit, 5-HT4 receptor agonist, scintigraphy, radiopaque markers
- MeSH terms
- Adult, Aged, Colon, Colonic Diseases, Functional, Constipation, Double-Blind Method, Gastrointestinal Transit, Guanidines, Humans, Indoles, Intestine, Small, Middle Aged, Radionuclide Imaging, Stomach, Time Factors, Serotonin Receptor Agonists
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