Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line

Wilson, KT; Ramanujam, KS; Mobley, HL; Musselman, RF; James, SP; Meltzer, SJ

doi:10.1016/s0016-5085(96)70014-8

Cited by 189Helicobacter pylori-related gastroenterology studiesInflammatory mediators and NSAID effectsImmune Response and Inflammation

Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line

Open access

Wilson, KT, Ramanujam, KS, Mobley, HL, Musselman, RF, James, SP, Meltzer, SJ·1996·Gastroenterology

DOI 10.1016/s0016-5085(96)70014-8

Open this paper in CoChat — free account

Abstract

Background & aims Helicobacter pylori uniquely colonizes the human stomach and produces gastric mucosal inflammation. High-output nitric oxide production by inducible nitric oxide synthase (iNOS) is associated with immune activation and tissue injury. Because mononuclear cells comprise a major part of the cellular inflammatory response to H. pylori infection, the ability of H. pylori to induce iNOS in macrophages was assessed.Methods H. pylori preparations were added to RAW 264.7 murine macrophages, and iNOS expression was assessed by Northern blot analysis, enzyme activity assay, and NO2- release.Results Both whole H. pylori and French press lysates induced concentration-dependent NO2- production, with peak levels 20-fold above control. These findings were paralleled by marked increases in iNOS messenger RNA and enzyme activity levels. iNOS expression was synergistically increased with interferon gamma, indicating that the H. pylori effect can be amplified by other macrophage-activating factors. Studies of lipopolysaccharide (LPS) content and polymyxin B inhibition of LPS suggested that the H. pylori effect was attributable to both LPS-dependent and -independent mechanisms.Conclusions iNOS expression in macrophages is activated by highly stable H. pylori products and may play an important role in the pathogenesis of H. pylori-associated gastric mucosal disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(96)70014-8

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis, induces iNOS and generates large quantities of NO, forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system.
“However, chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis induce inducible NOS (iNOS) and generate large quantities of NO [22,146,147], forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system [148,149].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [147]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,499 · see citing works
Amelioration of chronic ileitis by nitric oxide synthase inhibition.
Miller, M. J., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J. L., & Clark, D. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10238-3 · Cited by 407 · see citing works
Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes
Schneemann, M., Schoedon, G., Hofer, S., Blau, N., Guerrero, L., & Schaffner, A. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.6.1358 · Cited by 333 · see citing works
Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects.
Khulusi, S., Mendall, M. A., Patel, P., Levy, J., Badve, S., & Northfield, T. C. (1995) · Gut · doi:10.1136/gut.37.3.319 · Cited by 116 · see citing works
Adherence and internalization of Helicobacter pylori by HEp-2 cells
Evans, D. G., Evans, D. J., & Graham, D. Y. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91714-f · Cited by 111 · see citing works
Helicobacter pylori and Gastric Carcinoma
Shimizu, N., Tatematsu, M., & Kaminishi, M. (2006) · Springer eBooks · doi:10.1007/4-431-27713-7_4 · Cited by 25 · see citing works

Flagged first, then by citations

Research works printed but not linked: 19

Sherman PA, Laubach VE, Reep BR, Wood ER. Purification and 1. Whittle BJ, Lopez-Belmonte J, Moncada S. Regulation of gastric cDNA sequence of an inducible nitric oxide synthase from a hu- mucosal integrity by endogenous nitric oxide: interactions with man tumor cell line. Biochemistry 1993;32:11600-11605. prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 22. Tepperman BL, Brown JF, Whittle BJ. Nitric oxide synthase induc- 1990;99:607-611. tion and intestinal epithelial cell viability in rats. Am J Physiol 2. Miller MJ, Sadowska-Krowicka H, Chotinaruemol S, Kakkis JL, 1993;265:G214-G218.
Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee 4. Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, TD, Ding A, Troso T, Nathan C. Cloning and characterization of Whittle BJ, Moncada S. Nitric oxide synthase activity in ulcerative inducible nitric oxide synthase from mouse macrophages. Sci- colitis and Crohn's disease. Lancet 1993;342:338-340. ence 1992;256:225-228.
Mills SD, Kurjanczyk LA, Penner JL. Antigenicity of Helicobacter 5. Boughton-Smith NK, Evans SM, Whittle BJ, Moncada S. Induction of nitric oxide synthase in rat intestine and its association with pylori lipopolysaccharides. J Clin Microbiol 1992;30:3175- 3180. tissue injury. Agents Actions 1993;38:C125-C126. / 5e14$$0038 11-13-96 19:03:14 gasa WBS-Gastro
Westphal O, Jann K. Bacterial lipopolysaccharides: extraction Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995;81:641- with phenol-water and further applications of the procedure. Methods Carbohydr Chem 1965;5:83-91. 650.
Blaser MJ, Parsonnet J. Parasitism by the ''slow'' bacterium 27. Hochstein HD, Mills DF, Outschoorn AS, Rastogi SC. The pro- cessing and collaborative assay of a reference endotoxin. J Biol Helicobacter pylori leads to altered gastric homeostasis and neo- plasia. J Clin Invest 1994;94:4-8. Stand 1983;11:251-260.
Fox JG, Blanco M, Murphy JC, Taylor NS, Lee A, Kabok Z, Pappo 45. Birkholz S, Knipp U, Nietzki C, Adamek RJ, Opferkuch W. Immuno- logical activity of lipopolysaccharide of Helicobacter pylori on hu- J. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun 1993;61:2309- man peripheral mononuclear blood cells in comparison to lipo- polysaccharides of other intestinal bacteria. FEMS Immunol Med 2315.
Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene Microbiol 1993;6:317-324.
Mattsby-Baltzer I, Mielniczuk Z, Larsson L, Lindgren K, Goodwin encoding calcium-independent nitric oxide synthase confers in- ducibility by interferon gamma and bacterial lipopolysaccharide. S. Lipid A in Helicobacter pylori. Infect Immun 1992;60:4383- 4387. J Exp Med 1993;177:1779-1784.
Russell SW, Murphy WJ. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma 1992;186:775-781.
Schneemann M, Schoedon G, Hofer S, Blau N, Guerrero L, Schaff- and lipopolysaccharide. Proc Natl Acad Sci USA 1993;90:9730- 9734.
Dumarey CH, Labrousse V, Rastogi N, Vargaftig BB, Bachelet M. phages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Selective Mycobacterium avium-induced production of nitric oxide by human monocyte-derived macrophages. J Leukoc Biol 1994; Chem 1993;268:1908-1913.
Vouldoukis I, Riveros-Moreno V, Dugas B, Ouaaz F, Becherel P, Helicobacter pylori urease at wild-type levels in Escherichia coli. Infect Immun 1993;61:2563-2569.
Debre P, Moncada S, Mossalayi MD. The killing of Leishmania major by human macrophages is mediated by nitric oxide induced 33. Muotiala A, Helander IM, Pyhala L, Kosunen TU, Moran AP. Low biological activity of Helicobacter pylori lipopolysaccharide. Infect after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci USA 1995;92:7804-7808. Immun 1992;60:1714-1716.
Issekutz AC. Removal of gram-negative endotoxin from solutions 51. Paul-Eugene N, Mossalayi D, Sarfati M, Yamaoka K, Aubry JP, Bonnefoy JY, Dugas B, Kolb JP. Evidence for a role of Fc epsilon by affinity chromatography. J Immunol Methods 1983;61:275- 281. RII/CD23 in the IL-4-induced nitric oxide production by normal human mononuclear phagocytes. Cell Immunol 1995;163:314- 35.
Ohshima H, Bartsch H. Chronic infections and inflammatory pro- of Gastroenterology, University of Maryland School of Medicine, University of Maryland Hospital, Room N3W62, 22 South Greene cesses as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mut Res 1994;305:253-264.
Wilson KT, Musselman RF, El Mahdi L, Jones RT. Immunohisto- chemical detection of inducible nitric oxide synthase in Helico- Supported by grants R01-CA67497 (to S.J.M. and K.T.W.), DK47717 (to S.J.M.) and ES07120 (to S.J.M.) from the National bacter pylori gastritis (abstr). Gastroenterology 1995;108:A942.
Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated Institutes of Health; grant 9307-0502 from NASA (to S.J.M); grant EDT-37B from the American Cancer Society (to S.J.M.), the Medical apoptosis in murine peritoneal macrophages. J Immunol 1993; 150:5080-5085. Research Office, Department of Veterans Affairs (to S.J.M); and a Special Research Initiative Support grant from the University of Mary- 41.
De Groote MA, Granger D, Xu Y, Campbell G, Prince R, Fang FC. Genetic and redox determinants of nitric oxide cytotoxicity in a land School of Medicine (to K.T.W). Dr. Wilson is a recipient of a Career Development Award from the Crohn's and Colitis Foundation Salmonella typhimurium model. Proc Natl Acad Sci USA 1995; 92:6399-6403. of America. Presented at 1995 annual meeting of the American Gastroentero- 42.
Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxida- tion of sulfhydryls. The cytotoxic potential of superoxide and nitric logical association in San Diego, California. The authors thank Dr. Donald Hochstein at the Food and Drug oxide. J Biol Chem 1991;266:4244-4250.

Sorted by citations

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,455 · see citing works
“in macrophages in vitro (42, 117, 118, 339) and in vivo (103,”
Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.
Wilson, K. T., Fu, S., Ramanujam, K. S., & Meltzer, S. J. (1998) · PubMed · Cited by 591 · see citing works
Persistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 574 · see citing works
Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis☆, ☆☆
Fu, S. M., Ramanujam, K., WONG, A., Fantry, G. T., Drachenberg, C. B., James, S., Meltzer, S. J., & Wilson, K. T. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70496-8 · Cited by 408 · see citing works
Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival
Gobert, A. P., McGee, D. J., Akhtar, M., Mendz, G. L., Newton, J. C., Cheng, Y., Mobley, H. L. T., & Wilson, K. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241443798 · Cited by 380 · see citing works
Helicobacter pylori -Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-γ, Gene-Deficient Mice
Smythies, L. E., Waites, K. B., Lindsey, J. R., Harris, P. R., GHIARA, P., & Smith, P. D. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.1022 · Cited by 337 · see citing works
Novel Aspects of Dietary Nitrate and Human Health
Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324 · see citing works
Nitric Oxide in Inflammatory Bowel Disease
Cross, R. K., & Wilson, K. T. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200305000-00006 · Cited by 303 · see citing works
Pathogenesis and clinical management of Helicobacter pylori gastric infection
de Brito, B. B., da Silva, F. A. F., Soares, A. S., Pereira, V. A., Santos, M. L. C., Sampaio, M. M., Neves, P. H. M., & de Melo, F. F. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i37.5578 · Cited by 302 · see citing works
Immunology of Helicobacter pylori: Insights Into the Failure of the Immune Response and Perspectives on Vaccine Studies
Wilson, K. T., & Crabtree, J. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.008 · Cited by 279 · see citing works
Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis
Butcher, L. D., den Hartog, G., Ernst, P. B., & Crowe, S. E. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.002 · Cited by 248 · see citing works
Role of Innate Immunity inHelicobacter pylori-Induced Gastric Malignancy
Peek, R. M., Fiske, C., & Wilson, K. T. (2010) · Physiological Reviews · doi:10.1152/physrev.00039.2009 · Cited by 231 · see citing works
“pylori in macrophages in vitro (43, 99, 100, 296) and in vivo (88, 167).”
Biology of nitrogen oxides in the gastrointestinal tract
Lundberg, J. O., & Weitzberg, E. (2013) · Gut · doi:10.1136/gutjnl-2011-301649 · Cited by 200 · see citing works
Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II
Gobert, A. P., Cheng, Y., Wang, J., Boucher, J., Iyer, R. K., Cederbaum, S. D., Casero, R. A., Newton, J. C., & Wilson, K. T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4692 · Cited by 173 · see citing works
“pylori infection induces activation of an innate response program in macrophages (3), which includes increased expression of inducible NO synthase (iNOS)(3) and cyclooxygenase-2 (4, 5), and production of inflammatory mediators such as reactive oxygen intermediates, TNF- , and IL-1 (6).”
BackgroundMethodInfluential
Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract
Pergola, C., Rossi, A., Dugo, P., Cuzzocrea, S., & Sautebin, L. (2006) · Nitric Oxide · doi:10.1016/j.niox.2005.10.003 · Cited by 168 · see citing works
“The inducible NOS derived from macrophages is predominantly responsible for the overproduction of NO in injured tissues and inXammation processes [37].”
Background
Spermine Oxidation Induced by Helicobacter pylori Results in Apoptosis and DNA Damage
Xu, H., Chaturvedi, R., Cheng, Y., Bussière, F. I., Asim, M., Yao, M. D., Potosky, D. R., Meltzer, S. J., Rhee, J. G., Kim, S. S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-3511 · Cited by 168 · see citing works
Induction of Polyamine Oxidase 1 by Helicobacter pylori Causes Macrophage Apoptosis by Hydrogen Peroxide Release and Mitochondrial Membrane Depolarization
Chaturvedi, R., Cheng, Y., Asim, M., Bussière, F. I., Xu, H., Gobert, A. P., Hacker, A., Casero, R. A., & Wilson, K. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401370200 · Cited by 167 · see citing works
Helicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent Mechanism
Gobert, A. P., Bambou, J., Werts, C., Balloy, V., Chignard, M., Moran, A. P., & Ferrero, R. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307858200 · Cited by 164 · see citing works
Spermine Causes Loss of Innate Immune Response to Helicobacter pylori by Inhibition of Inducible Nitric-oxide Synthase Translation
Bussière, F. I., Chaturvedi, R., Cheng, Y., Gobert, A. P., Asim, M., Blumberg, D. R., Xu, H., Kim, P. Y., Hacker, A., Casero, R. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400498200 · Cited by 144 · see citing works
Review article:Helicobacter pyloriand gastro‐oesophageal reflux disease—clinical implications and management
O’Connor (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00460.x · Cited by 138 · see citing works
Gastro‐oesophageal reflux disease in Asia
Goh, K., Chang, C., Fock, K., Ke, M., Park, H., & Lam, S. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02148.x · Cited by 137 · see citing works
Streptococcus anginosus infection in oral cancer and its infection route
Sasaki, M., Yamaura, C., Ohara‐Nemoto, Y., Tajika, S., Kodama, Y., Ohya, T., Harada, R. M., & Kimura, S. (2005) · Oral Diseases · doi:10.1111/j.1601-0825.2005.01051.x · Cited by 134 · see citing works
Chronic inflammation and oxidative stress
Hardbower, D. M., de Sablet, T., Chaturvedi, R., & Wilson, K. T. (2013) · Gut Microbes · doi:10.4161/gmic.25583 · Cited by 134 · see citing works
Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation
Chen, Y.-H., Tsai, W.-H., Wu, H.-Y., Chun-ya, C., Yeh, W.-L., Chen, Y.-H., Hsu, H.-Y., Chen, W., Chen, Y., Chang, W., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010090 · Cited by 132 · see citing works
“inflammatory mediators, including IL-8, COX-2, and nitric oxide (NO), which are closely associated with tissue inflammation and injury [42].”
Background
Cutting Edge: Urease Release by Helicobacter pylori Stimulates Macrophage Inducible Nitric Oxide Synthase
Gobert, A. P., Mersey, B. D., Cheng, Y., Blumberg, D. R., Newton, J. C., & Wilson, K. T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6002 · Cited by 130 · see citing works
“pylori directly stimulates murine macrophage NO production through the induction of iNOS expression (11, 12).”
BackgroundMethodInfluential
Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates
Philpott, D. J., Belaid, D., Troubadour, P., Thiberge, J.-M., Tankovic, J., Labigne-Roussel, A., & Ferrero, R. L. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00189.x · Cited by 125 · see citing works
“…cell components, induced the synthesis in macrophages of pro-inflammatory factors such as IL-1b, TNF-a and nitric oxide (Harris et al., 1996; 1998; Wilson et al., 1996; Assmann et al., 2001), the mechanisms by which the expression of such factors is regulated have not yet been characterized.”
Background
Helicobacter pylori in gastro-oesophageal reflux disease: causal agent, independent or protective factor?
LABENZ, J., & Malfertheiner, P. (1997) · Gut · doi:10.1136/gut.41.3.277 · Cited by 127 · see citing works
Pathogenesis of Helicobacter pylori infection
McGee, D. J., & Mobley, H. L. T. (2000) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200001000-00005 · Cited by 127 · see citing works
Role of urease in megasome formation and Helicobacter pylori survival in macrophages
Schwartz, J. T., & Allen, L. H. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106030 · Cited by 117 · see citing works
“Intact Hp and bacterial extracts induce macrophage iNOS, and urease has been implicated in this process [39, 40].”
Background
Helicobacter pylori induces promoter methylation of E‐cadherin via interleukin‐1β activation of nitric oxide production in gastric cancer cells
Huang, F., Chan, A. O., Rashid, A., Wong, D. K.-H., Cho, C., & Yuen, M. (2012) · Cancer · doi:10.1002/cncr.27519 · Cited by 113 · see citing works
“pylori infection also stimulates expression of inducible nitric oxide synthase (iNOS) in the invading macrophages as well as in the gastric mucosa.(9) Generation of nitric oxide (NO) by iNOS activation is a common strategy by the host to eradicateH.”
Background
Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract
van der Woude, C. J., Kleibeuker, J. H., Jansen, P. L. M., & Moshage, H. J. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000018794.26438.22 · Cited by 111 · see citing works
Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis
Kalisperati, P., Spanou, E., Pateras, I. S., Korkolopoulou, P. A., Varvarigou, A. A., Karavokyros, I., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Sougioultzis, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00020 · Cited by 108 · see citing works
“The bacterium survives oxidative stress by the production of the enzymes Nap A, catalase and superoxide catalase; thus, leading to persistent immunocyte infiltration in the gastric mucosa and further enhancement of oxidative burst (Wilson et al., 1996; Ramarao et al., 2000).”
Background
Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells.
Akhtar, M., Cheng, Y., Magno, R. M., Ashktorab, H., Smoot, D. T., Meltzer, S. J., & Wilson, K. T. (2001) · PubMed · Cited by 108 · see citing works
l -Arginine Availability Regulates Inducible Nitric Oxide Synthase-Dependent Host Defense againstHelicobacter pylori
Chaturvedi, R., Asim, M., Lewis, N. D., Algood, H. M. S., Cover, T. L., Kim, P. Y., & Wilson, K. T. (2007) · Infection and Immunity · doi:10.1128/iai.00578-07 · Cited by 102 · see citing works
“pylori lysates prepared with a French press (7, 47), and”
BackgroundMethod
Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-κB-mediated iNOS protein expression
Aktan, F., Henness, S., Roufogalis, B. D., & Ammit, A. J. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00032-6 · Cited by 104 · see citing works
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production
Chaturvedi, R., Asim, M., Hoge, S., Lewis, N. D., Singh, K., Barry, D. P., de Sablet, T., Piazuelo, M. B., Sarvaria, A. R., Cheng, Y., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.060 · Cited by 101 · see citing works
ADAMs(A Disintegrin and Metalloproteinase) Messenger RNA Expression inHelicobacter pylori–Infected, Normal, and Neoplastic Gastric Mucosa
Yoshimura, T., Tomita, T., Dixon, M. F., Axon, A. T. R., Robinson, P. A., & Crabtree, J. E. (2002) · The Journal of Infectious Diseases · doi:10.1086/338191 · Cited by 96 · see citing works
Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice
Kaparakis‐Liaskos, M., Walduck, A. K., Price, J. D., Pedersen, J. S., van Rooijen, N., Pearse, M. J., Wijburg, O. L. C., & Strugnell, R. A. (2008) · Infection and Immunity · doi:10.1128/iai.01481-07 · Cited by 95 · see citing works
“pylori gastritis, as it is up-regulated in patients with chronic active gastritis or gastritis with intestinal metaplasia (23).”
Background
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Decreased Prevalence of Helicobacter pylori Infection in Gastroesophageal Reflux Disease
Varanasi, R. V., Fantry, G. T., & Wilson, K. T. (1998) · Helicobacter · doi:10.1046/j.1523-5378.1998.08001.x · Cited by 93 · see citing works
Arginase II Restricts Host Defense to Helicobacter pylori by Attenuating Inducible Nitric Oxide Synthase Translation in Macrophages
Lewis, N. D., Asim, M., Barry, D. P., Singh, K., de Sablet, T., Boucher, J., Gobert, A. P., Chaturvedi, R., & Wilson, K. T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902436 · Cited by 93 · see citing works
“Macrophages were activated with either live bacteria or lysates prepared with a French press (13), and MOIs were determined in lysates as described (12).”
Method
Modulation of Innate Cytokine Responses by Products of Helicobacter pylori
Meyer, F. P., Wilson, K. T., & James, S. P. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6265-6272.2000 · Cited by 92 · see citing works
“pylori production seem to be due to innate responses of the epithelium that are not dependent on cognate immunity, such as marked upregulation of NF-kB (10), IL-8 production (10), iNOS (15, 38, 48), COX-2 (15), and inflammatory cytokines (8, 10, 38).”
Background
Carcinogenesis, apoptosis and cell proliferation
Correa, P., & Miller, M. J. S. (1998) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011665 · Cited by 92 · see citing works
At the Bench: Helicobacter pylori , dysregulated host responses, DNA damage, and gastric cancer
Hardbower, D. M., Peek, R. M., & Wilson, K. T. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.4bt0214-099r · Cited by 86 · see citing works
Inflammation and Gastric Cancer
Jaroenlapnopparat, A., Bhatia, K., & Çoban, Ş. (2022) · Diseases · doi:10.3390/diseases10030035 · Cited by 86 · see citing works
Helicobacter pylori Induces ERK-dependent Formation of a Phospho-c-Fos·c-Jun Activator Protein-1 Complex That Causes Apoptosis in Macrophages
Asim, M., Chaturvedi, R., Hoge, S., Lewis, N. D., Singh, K., Barry, D. P., Algood, H. M. S., de Sablet, T., Gobert, A. P., & Wilson, K. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116988 · Cited by 84 · see citing works
Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II
Lewis, N. D., Asim, M., Barry, D. P., de Sablet, T., Singh, K., Piazuelo, M. B., Gobert, A. P., Chaturvedi, R., & Wilson, K. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003431 · Cited by 81 · see citing works
“Concentrations of bacteria were determined by OD at 600 nm (OD of 1 = 10(9) CFU/ml) (16).”
Method
iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion
Binion, D. G., Fu, S., Ramanujam, K. S., Chai, Y.-C., Dweik, R. A., Drazba, J. A., Wade, J. G., Ziats, N. P., ERZURUM, S. C., & Wilson, K. T. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.3.g592 · Cited by 80 · see citing works
“There is immunohistochemical evidence suggesting that iNOS can be detected in the inflamed mucosal microvascular endothelium, although expression is lower than is typically detected in the lamina propria mononuclear cell population, as well as the epithelium (50, 51).”
Background
Immune subversion by Helicobacter pylori
Baldari, C. T., Lanzavecchia, A., & Telford, J. L. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.01.007 · Cited by 76 · see citing works
Resveratrol Protects against Helicobacter pylori-Associated Gastritis by Combating Oxidative Stress
Zhang, X., Jiang, A., Qi, B., Ma, Z., Xiong, Y., Dou, J., & Wang, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126061 · Cited by 75 · see citing works
“pylori-associated gastritis is that the production of large amounts of ROS and reactive nitrogen species (RNS) likely leads to an imbalance between removing the production of ROS/RNS and antioxidant defenses, which is the main cause of chronic gastritis [4,32,33].”
Background
Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection
Hardbower, D. M., Asim, M., Stewart, T. M., Casero, R. A., Verriere, T. G., Lewis, N. D., Chaturvedi, R., Piazuelo, M. B., & Wilson, K. T. (2016) · Amino Acids · doi:10.1007/s00726-016-2231-2 · Cited by 75 · see citing works
“ARG2 and NOS2 are both highly inducible in macrophages during H. pylori infection (Gobert et al. 2002a; Shapiro and Hotchkiss 1996; Wilson et al. 1996).”
NF-κB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection
Lim, J. W., Kim, H., & Kim, K. H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00592-5 · Cited by 74 · see citing works
Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.
Brito, S. A., de Almeida, C. L. F., de Santana, T. Í., Oliveira, A. R. D. S., Figueiredo, J. C. B. D. N., Souza, I. T., de Almeida, L. L., da Silva, M. V., Borges, A. S., de Medeiros, J. W., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1731459 · Cited by 68 · see citing works
“pylori infection-related stomach cancer [96].”
Background
Helicobacter pylori-induced Macrophage Apoptosis Requires Activation of Ornithine Decarboxylase by c-Myc
Cheng, Y., Chaturvedi, R., Asim, M., Bussière, F. I., Xu, H., Casero, R. A., & Wilson, K. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500122200 · Cited by 68 · see citing works
The immune Battle against helicobacter pylori infection: NO offense
Gobert, A. P., & Wilson, K. T. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.005 · Cited by 63 · see citing works
“pylori is in direct contact with murine macrophages, a strong NOS2 induction and a high level of NO production are observed in the cells [32,35].”
Cutting Edge: Cyclooxygenase-2 Activation Suppresses Th1 Polarization in Response to Helicobacter pylori
Meyer, F. P., Ramanujam, K. S., Gobert, A. P., James, S. P., & Wilson, K. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.3913 · Cited by 63 · see citing works
“pylori was harvested into sterile PBS and concentration was determined by OD (1, 19).”
BackgroundMethodInfluential
Peptidoglycan Deacetylation in Helicobacter pylori Contributes to Bacterial Survival by Mitigating Host Immune Responses
Wang, G., Maier, S. E., Lo, L. F., Maier, G. A., Dosi, S., & Maier, R. J. (2010) · Infection and Immunity · doi:10.1128/iai.00307-10 · Cited by 63 · see citing works
“pylori stimulates the generation of NO in macrophages through the enzyme-inducible NO synthase (iNOS) (39), and H.”
Background
Up-regulation of inducible nitric oxide synthase in Helicobacter pylori-associated gastritis may represent an increased risk factor to develop gastric carcinoma of the intestinal type
Rieder, G., Hofmann, J. A., Hatz, R. A., Stolte, M., & Enders, G. A. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00280 · Cited by 62 · see citing works
Intestinal anti-inflammatory activity ofSasa quelpaertensisleaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells
Kim, K.-M., Kim, Y. S., Lim, J. Y., Min, S. J., Ko, H., Kim, Y., & Kim, Y. (2015) · Nutrition Research and Practice · doi:10.4162/nrp.2015.9.1.3 · Cited by 63 · see citing works
“It is well-known that macrophages overproduce NO in response to iNOS during the inflammation process [23].”
Background
Features of gastritis predisposing to gastric adenoma and early gastric cancer
Meining, A. G., Riedl, B., & Stolte, M. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.10.770 · Cited by 61 · see citing works
Review article: inflammation‐related promotion of gastrointestinal carcinogenesis – a perigenetic pathway
Tsuji, S., Kawai, N., Tsujii, M., Kawano, S., & Hori, M. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.18.s1.22.x · Cited by 57 · see citing works
Helicobacter pylori and tonsillectomy
Skinner, L. J., Winter, D. C., Curran, A., Barnes, C., Kennedy, S., Maguire, A., Charles, D. A., Timon, C., & Burns, H. P. (2001) · Clinical Otolaryngology · doi:10.1046/j.1365-2273.2001.00513.x · Cited by 54 · see citing works
Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells.
Sh, J., Jw, L., & Kim, H. (2009) · PubMed · Cited by 54 · see citing works
The role of nitric oxide in peptic ulcer
Liang, T., Deng, R., Li, X., Xu, X. M., & Chen, G. (2021) · Medical Gas Research · doi:10.4103/2045-9912.310059 · Cited by 57 · see citing works
Naturally acquired human immune responses againstHelicobacter pylori and implications for vaccine development
Zevering, Y., Jacob, L. D., & Meyer, T. F. (1999) · Gut · doi:10.1136/gut.45.3.465 · Cited by 52 · see citing works
Vaccine development against Helicobacter pylori: from ideal antigens to the current landscape
Viana, I. D. S., Santos, M. L. C., Marques, H. S., Gonçalves, V. L. D. S., de Brito, B. B., da Silva, F. A. F., Silva, N. O. E., Pinheiro, F. D., Teixeira, A. F., Costa, D. T., et al. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1945450 · Cited by 51 · see citing works
“The initial activation of the immune system leads to the recruitment of phagocytes especially to the gastric mucosa [26].”
Background
VIRULENCE AND PATHOGENICITY OF HELICOBACTER PYLORI
Go, M. F., & Crowe, S. E. (2000) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70136-9 · Cited by 48 · see citing works
Oxidative and nitrosative stress defences ofHelicobacterandCampylobacterspecies that counteract mammalian immunity
Flint, A., Stintzi, A., & Saraiva, L. M. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw025 · Cited by 47 · see citing works
“…guest on 15 M arch 2020 epithelial cells, neutrophils and macrophages, as judged by the higher systemic and intraluminal levels of stable NO-derived metabolites (nitrite and nitrate) measured in H. pylori-infected patients (Shapiro and Hotchkiss 1996; Wilson et al. 1996; Cherdantseva et al. 2014).”
Background
Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter Pylori gastric ulcer
Sakaguchi, A. A., Miura, S., Takeuchi, T., Hokari, R., Mizumori, M., Yoshida, H., Higuchi, H., Mori, M., Kimura, H., Suzuki, H., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00124-0 · Cited by 47 · see citing works
Hygiene Could Affect GERD Prevalence Independently: A Population-Based Study in Tehran
Nouraie, M. S., Radmard, A. R., Zaer-Rezaee, H., Razjouyan, H., Nasseri‐Moghaddam, S., & Malekzadeh, R. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01208.x · Cited by 46 · see citing works
Evaluation of Salicornia herbacea as a Potential Antioxidant and Anti-Inflammatory Agent
Kim, Y. A., Kong, C., Um, Y. R., Lim, S., Yea, S. S., & Seo, Y. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.1072 · Cited by 44 · see citing works
“38 It has been reported that TNF-a and IL-1 b are potent pro-inﬂammatory cytokines and the quantity and duration of their presence play important roles in the inﬂammatory process.”
Low Multiplicity of Infection ofHelicobacter pyloriSuppresses Apoptosis of B Lymphocytes
Bussière, F. I., Chaturvedi, R., Asim, M., Hoek, K. L., Cheng, Y., Gainor, J. F., Scholz, A., Khan, W. N., & Wilson, K. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4197 · Cited by 43 · see citing works
“pylori , in which low MOI (1-10) markedly inhibited apoptosis, whereas high MOI (z75) potentiated apoptosis.”
BackgroundInfluential
Dual Action of Nitric Oxide in the Pathogenesis of Ischemia/Reperfusion-Induced Mucosal Injury in Mouse Stomach
Kobata, A., Kotani, T., Komatsu, Y., Amagase, K., Kato, S., & Takeuchi, K. (2007) · Digestion · doi:10.1159/000108590 · Cited by 40 · see citing works
“The present study showed that the severity of I/R- induced gastric lesions was significantly reduced by pretreatment with 1400W, a selective iNOS inhibitor. Furthermore, we observed that the gene expression of iNOS but not cNOS was markedly up-regulated in the stomach following I/R, accompanied by a significant increa…”
Background
Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction
Barry, D. P., Asim, M., Leiman, D. A., de Sablet, T., Singh, K., Casero, R. A., Chaturvedi, R., & Wilson, K. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017510 · Cited by 40 · see citing works
“pylori strains SS1 [19] and 60190 [20] were maintained by passage on plates of tryptic soy agar containing 5% sheep blood, as described [21].”
Method
Helicobacter pylori induces apoptosis in gastric epithelial cells through inducible nitric oxide
Watanabe, S., Takagi, A., Koga, Y., & Kamiya, S. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02062.x · Cited by 40 · see citing works
Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Latour, Y. L., Sierra, J. C., Finley, J. L., Asim, M., Barry, D. P., Allaman, M. M., Smith, T. M., McNamara, K. M., Luis, P. B., Schneider, C. G., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155338 · Cited by 38 · see citing works
Expression of COX-1, COX-2, and inducible nitric oxide synthase protein in human gastric antrum with Helicobacter pylori infection☆
Franco, L., Talamini, G., Carra, G., & Dória, D. (1999) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(99)00020-9 · Cited by 37 · see citing works
Changes in gastric mucosa and luminal environment during acid-suppressive therapy: a review in depth
Sanduleanu, S., Jonkers, D. M. A. E., A, A. P. D. B., Hameeteman, W. M., & Stockbrügger, R. W. (2001) · Digestive and Liver Disease · doi:10.1016/s1590-8658(01)80050-5 · Cited by 36 · see citing works
Enhanced Expression of Inducible Nitric Oxide Synthase in Chronic Gastritis With Intestinal Metaplasia
Tatemichi, M., Ogura, T., Nagata, H., & Esumi, H. (1998) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199810000-00012 · Cited by 35 · see citing works
Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis
Feichtinger, R. G., Neureiter, D., Skaria, T., Weßler, S., Cover, T. L., Mayr, J. A., Zimmermann, F., Posselt, G., Sperl, W., & Kofler, B. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1320241 · Cited by 34 · see citing works
“It is highly doubtful that the high MOIs (100–400) which are usually used for cell culture experiments would be reached during infection in vivo [65, 66].”
Background
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway
Gobert, A. P., Latour, Y. L., Asim, M., Finley, J. L., Verriere, T. G., Barry, D. P., Milne, G. L., Luis, P. B., Schneider, C. G., Rivera, E. S., et al. (2019) · mBio · doi:10.1128/mbio.02174-19 · Cited by 34 · see citing works
“…(i) inducible nitric oxide synthase (NOS2)- derived nitric oxide (NO), which is mainly produced by macrophages and affects H. pylori growth (5–7) but has also been associated with gastric carcinogenesis (8), and (ii) carbon monoxide (CO), synthesized by heme-oxygenase 1, which impairs the…”
Adherence and Colonization
Testerman, T. L., McGee, D. J., & Mobley, H. L. T. (2014) · ASM Press eBooks · doi:10.1128/9781555818005.ch34 · Cited by 34 · see citing works
Induction of nitric oxide synthase in vivo and cell injury in rat duodenal epithelium by a water soluble extract of Helicobacter pylori
Lamarque, D., Kiss, J., Tankovic, J., Fléjou, J. F., Delchier, J., & Whittle, B. J. R. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701706 · Cited by 33 · see citing works
“Recent in vitro studies have shown that extracts of H. pylori can lead to the expression of iNOS in murine and human macrophage cell lines in culture (Perez-Perez et al., 1995; Shapiro et al., 1996; Wilson et al., 1996).”
Result
Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium–induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation
Kim, K., Kim, Y. S., Lim, J. Y., Min, S. J., Shin, J.-H., Ko, H.-C., Kim, S., Lim, Y., & Kim, Y. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.09.002 · Cited by 32 · see citing works
“Thus, suppression of NO production and activity represents a therapeutic target [44].”
Background
Differential Roles of ASK1 and TAK1 in Helicobacter pylori-Induced Cellular Responses
Hayakawa, Y., Hirata, Y., Kinoshita, H., Sakitani, K., Nakagawa, H., Nakata, W., Takahashi, R., Sakamoto, K., Maeda, S., & Koike, K. (2013) · Infection and Immunity · doi:10.1128/iai.00914-13 · Cited by 30 · see citing works
Supplementation with Angelica keiskei inhibits expression of inflammatory mediators in the gastric mucosa of Helicobacter pylori–infected mice
Kim, A., Lim, J. W., Kim, H., & Kim, H. (2016) · Nutrition Research · doi:10.1016/j.nutres.2015.12.017 · Cited by 29 · see citing works
“Furthermore, iNOS expression and activity in macrophages were enhanced by H pylori infection [49].”
Background
Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine
Chaturvedi, R., Asim, M., Barry, D. P., Frye, J., Casero, R. A., & Wilson, K. T. (2013) · Amino Acids · doi:10.1007/s00726-013-1531-z · Cited by 29 · see citing works
“Keywords Macrophages Gastric cancer Spermine oxidase Host defense Innate immune response Polyamines”
BackgroundMethodInfluential
Oxidative Stress in Gastric Mucosa of Asymptomatic Humans Infected with Helicobacter pylori: Effect of Bacterial Eradication
Felley, C. P., Pignatelli, B., van Melle, G. D., Crabtree, J. E., Stolte, M., Diézi, J., Corthésy-Theulaz, I. E., Michetti, P., Bancel, B., Patricot, L. M., et al. (2002) · Helicobacter · doi:10.1046/j.1523-5378.2002.00107.x · Cited by 29 · see citing works
Helicobacter pylori Induces Hypermethylation of CpG Islands Through Upregulation of DNA Methyltransferase: Possible Involvement of Reactive Oxygen/Nitrogen Species
Na, H., & Woo, J.-H. (2014) · Journal of Cancer Prevention · doi:10.15430/jcp.2014.19.4.259 · Cited by 28 · see citing works
“pylori infection stimulates expression of iNOS in the invading macrophages as well as in the gastric mucosa.(35) H.”
Background
Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucosa before and after Helicobacter pylori eradication
Kimura, A., Tsuji, S., Tsujii, M., Sawaoka, H., Iijima, H., Kawai, N., Yasumaru, M., Kakiuchi, Y., Okuda, Y., Ali, Z., et al. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0220 · Cited by 28 · see citing works
Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways
Tavares, R., & Pathak, S. K. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.09.037 · Cited by 27 · see citing works
Multifunctional SDF-1-loaded hydroxyapatite/polylactic acid membranes promote cell recruitment, immunomodulation, angiogenesis, and osteogenesis for biomimetic bone regeneration
Li, X., Wei, L., Li, J., Shao, J., Yi, B., Zhang, C., Liu, H., Ma, B., & Ge, S. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.100942 · Cited by 27 · see citing works
Exhaled nitric oxide as a potential marker for detecting non-ulcer dyspepsia and peptic ulcer disease
Som, S., Banik, G. D., Maity, A., Chaudhuri, S., & Pradhan, M. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa8efb · Cited by 26 · see citing works
Bioevaluation of Anisomeles indica extracts and their inhibitory effects on Helicobacter pylori-mediated inflammation
Lien, H., Wang, C. Y., Chang, H. Y., Huang, C. L., Peng, M., Sing, Y.-T., Chen, C. C., & Lai, C. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.11.015 · Cited by 26 · see citing works
Helicobacter pylori Extract Induces Nuclear Factor-kappa B, Activator Protein-1, and Cyclooxygenase-2 in Esophageal Epithelial Cells
Abdel-Latif, M., Windle, H. J., Terres, A. M., Eidhin, D. N., Kelleher, D. P., & Reynolds, J. V. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2005.09.003 · Cited by 23 · see citing works
Suppressed Gastric Mucosal TGF-β1 Increases Susceptibility to H. pylori-Induced Gastric Inflammation and Ulceration: A Stupid Host Defense Response
Jo, Y., Han, S., Kim, Y. J., Kim, J. H., Kim, S. T., Kim, S.-J., & Hahm, K. (2010) · Gut and Liver · doi:10.5009/gnl.2010.4.1.43 · Cited by 25 · see citing works
Drug Delivery through Phagocytosis of Red Blood Cells
Serafini, S., Rossi, L., Antonelli, A., Fraternale, A., Cerasi, A., Crinelli, R., Chiarantini, L., Schiavano, G. F., & Magnani, M. (2004) · Transfusion Medicine and Hemotherapy · doi:10.1159/000078042 · Cited by 25 · see citing works
Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication
Papadaki, H. Α., Skordilis, P., Minadakis, G., Roussomoustakaki, M., Katrinakis, G., Psyllaki, M., Tzardi, M. N., Kouroumalis, E., & Eliopoulos, G. D. (2003) · Annals of Hematology · doi:10.1007/s00277-003-0701-6 · Cited by 25 · see citing works
“Locally produced inflammation leads to the production of toxic oxygen radicals and nitric oxide, contributing to tissue injury and acting as strong mutagenic substances [2, 3, 24].”
Background
Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer
Lin, T., Lan, W.-H., Chiu, Y., Feng, C., Chiu, C., Kuo, C., & Lai, C. (2021) · Antioxidants · doi:10.3390/antiox10081293 · Cited by 24 · see citing works
The CrdRS two‐component system in H elicobacter pylori responds to nitrosative stress
Hung, C.-L., Cheng, H., Hsieh, W., Tsai, Z. T., Tsai, H., Chu, C., Hsieh, W., Chen, Y., Tsou, Y., Lai, C., et al. (2015) · Molecular Microbiology · doi:10.1111/mmi.13089 · Cited by 23 · see citing works
“pylori 26695 infection have shown that the bacterium induces innate immune responses, which induce the recruitment of neutrophils, monocytes and macrophages to the site of infection, the expression of inducible nitric oxide (NO) synthase and production of NO (Wilson et al., 1996; Fu et al., 1999; Chaturvedi et al., 20…”
Background

Helicobacter pylori stimulates inducible nitric oxide syntahse (iNOS) expression and activity in macrophages
Musselman, R. F. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)28071-5
Association ofHelicobacter pyloriand iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis
Александровна, Ч. Л., Potapova, O. V., Sharkova, T. V., Belyaeva, Y. Y., & Shkurupiy, V. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/762514 · Cited by 28 · see citing works
HELICOBACTER PYLORI INFECTION INCREASES NITRIC OXIDE (NO) AND INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) PRODUCTION BY EUKARYOTIC CELLS IN VITRO
Gold, B. D., Khanna, B., Newman, G. W., Owens, M. L., Harris, F. L., & Brown, L. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199710000-00111
HELICOBACTER PYLORI INFECTION INCREASES NITRIC OXIDE (NO) AND INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) PRODUCTION BY EUKARYOTIC CELLS IN VITRO:94
Gold, B. D., Khanna, B., Newman, G. W., Owens, M. L., Harris, F. L., & Brown, L. A. S. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1997.tb01902.x
Expression of Inducible Nitric Oxide Synthase and Nitric Oxide Production in Human Gastric Epithelial Cells Infected with Helicobacter pylori
Kim, J. M., Kim, J., Jung, H., Song, I.-S., & Kim, C.-Y. (2002) · Korean Journal of Gastroenterology

Authors: Wilson, K., Ramanujam, K., Mobley, H., Musselman, R., James, S., & Meltzer, S.
Affiliations: University of Maryland, Baltimore (US)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1996-12
Volume: 111
Issue: 6
Pages: 1524-1533
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(96)70014-8
OpenAlex: W2072178703
Cited by: 189
References: 6
Citations by year: 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 5
FWCI: 8.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01es007120-03, 5r01ca067497-03)
National Cancer Institute (R01-CA67497)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 47717, R01DK047717)
National Institute of Environmental Health Sciences (ES07120)
Topics: Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Helicobacter pylori, inducible nitric oxide synthase, nitric oxide production, macrophages, RAW 264.7 macrophages, lipopolysaccharide, polymyxin B, interferon-gamma, gastritis, gastric cancer, bacterial virulence factors, gastric mucosa colonization, nitric oxide synthase inhibition, interleukin-1
MeSH terms: Animals, Cell Line, Humans, Interferon-gamma, Macrophage Activation, Macrophages, Helicobacter pylori, Helicobacter Infections, Nitric Oxide Synthase, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks