The pathobiology of biliary epithelia

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Development and Characterization

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Characterization of cytosolic Ca2+ signaling in rat bile duct epithelia

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Disappearing Intrahepatic Bile Ducts: The Syndromes and Their Mechanisms

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Ca(2+)-activated C1- channels in a human biliary cell line: regulation by Ca2+/calmodulin-dependent protein kinase

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Characteristics of cholesterol absorption by human gall bladder: relevance to cholesterolosis.

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The origin of and subcellular mechanisms causing pancreatic bicarbonate secretion

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Endothelin-1 is synthesized and inhibits cyclic adenosine monophosphate- dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells.

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A Minimally Toxic Dose of Methylene Dianiline Injures Biliary Epithelial Cells in Rats

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Autosomal dominant polycystic kidney disease decreases anion exchanger activity

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Enterohepatic Circulation

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Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

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MRP3, an organic anion transporter able to transport anti-cancer drugs

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Physiology of Cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120019 · Cited by 240 · see citing works

Nitric oxide–mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes

Jaiswal, M., LaRusso, N. F., Shapiro, R. A., Billiar, T. R., & Gores, G. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.20875 · Cited by 230 · see citing works

Interleukin-6 Contributes to Mcl-1 Up-regulation and TRAIL Resistance via an Akt-Signaling Pathway in Cholangiocarcinoma Cells

Kobayashi, S., Werneburg, N. W., Bronk, S. F., Kaufmann, S. H., & Gores, G. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.010 · Cited by 226 · see citing works

Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line

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Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats

Alvaro, D., Alpini, G. D., Onori, P., Perego, L., Svegliati‐Baroni, G., Franchitto, A., Baiocchi, L., Glaser, S. S., LeSage, G., Folli, F. B., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.20184 · Cited by 196 · see citing works

Regulation of cholangiocyte bicarbonate secretion

Kanno, N., LeSage, G., Glaser, S. S., & Alpini, G. D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g612 · Cited by 158 · see citing works

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

Fingas, C. D., Bronk, S. F., Werneburg, N. W., Mott, J. L., Guicciardi, M. E., Cazanave, S. C., Mertens, J. C., Sirica, A. E., & Gores, G. J. (2010) · Hepatology · doi:10.1002/hep.24588 · Cited by 157 · see citing works

Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells

Ishimura, N., Isomoto, H., Bronk, S. F., & Gores, G. J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00242.2005 · Cited by 155 · see citing works

Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion

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Localisation of parasite antigens and inflammatory responses in experimental opisthorchiasis

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Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties

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Mechanisms of carbon acquisition for endosymbiont photosynthesis in Anthozoa

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Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts

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Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium

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Loss of Inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis

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Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

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Lipopolysaccharide Induces Cholangiocyte Proliferation Via An Interleukin–6-Mediated Activation of P44/P42 Mitogen–Activated Protein Kinase

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Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis

LeSage, G., Glaser, S. S., Ueno, Y., Alvaro, D., Baiocchi, L., Kanno, N., Phinizy, J. L., Francis, H., & Alpini, G. D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g182 · Cited by 121 · see citing works

Acute Carbon Tetrachloride Feeding Selectively Damages Large, But Not Small, Cholangiocytes From Normal Rat Liver

LeSage, G., Benedetti, A., Glaser, S. S., Marucci, L., Tretjak, Z., Caligiuri, A., Rodgers, R., Phinizy, J. L., Baiocchi, L., Francis, H., et al. (1999) · Hepatology · doi:10.1002/hep.510290242 · Cited by 115 · see citing works

Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial–mesenchymal transition and chemoresistance in biliary tract cancer

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The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

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Regulation and deregulation of cholangiocyte proliferation

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Inducible Nitric Oxide Synthase Up-Regulates Notch-1 in Mouse Cholangiocytes: Implications for Carcinogenesis

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Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat

Alvaro, D., Onori, P., Metalli, V. D., Svegliati‐Baroni, G., Folli, F. B., Franchitto, A., Alpini, G. D., Mancino, M. G., Attili, A. F., & Gaudio, E. (2002) · Hepatology · doi:10.1053/jhep.2002.34741 · Cited by 110 · see citing works

Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study

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Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia

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The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver

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Calcium Signaling in the Liver

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Regulation of cholangiocyte proliferation

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Effects of bile acids on biliary epithelial cells: Proliferation, cytotoxicity, and cytokine secretion

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Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling

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Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

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H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1

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Antibody to carbonic anhydrase II is present in primary biliary cirrhosis (PBC) irrespective of antimitochondrial antibody status

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Quantitative Assessment of the Rat Intrahepatic Biliary System by Three-Dimensional Reconstruction

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Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes

Alvaro, D., Gigliozzi, A., Attili, A. F., Onori, P., Franchitto, A., Vetuschi, A., Glaser, S. S., LeSage, G., Alpini, G. D., Morini, S., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34169 · Cited by 69 · see citing works

Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver

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Comparative histopathology of Opisthorchis felineus and Opisthorchis viverrini in a hamster model: An implication of high pathogenicity of the European liver fluke

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Enhancer of Zeste Homolog 2 (EZH2) Promotes Progression of Cholangiocarcinoma Cells by Regulating Cell Cycle and Apoptosis

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Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth

Ishimura, N., Bronk, S. F., & Gores, G. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00539.2003 · Cited by 66 · see citing works

Hepatobiliary Transport: Molecular Mechanisms of Development and Cholestasis

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A smac mimetic reduces TNF Related Apoptosis Inducing Ligand (TRAIL)‐induced invasion and metastasis of cholangiocarcinoma cells†

Fingas, C. D., Blechacz, B. R. A., Smoot, R. L., Guicciardi, M. E., Mott, J. L., Bronk, S. F., Werneburg, N. W., Sirica, A. E., & Gores, G. J. (2010) · Hepatology · doi:10.1002/hep.23729 · Cited by 64 · see citing works

Molecular aspects of medicine: from experimental to clinical hepatology

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Regulation of cholangiocyte bile secretion

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Mechanisms of biliary carcinogenesis and growth

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Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium

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Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices

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Animal models for primary sclerosing cholangitis

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Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation

DeMorrow, S., Francis, H., Gaudio, E., Ueno, Y., Venter, J. K., Onori, P., Franchitto, A., Vaculin, B. T., Vaculin, S., & Alpini, G. D. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2007 · Cited by 53 · see citing works

Targeting PDGFR ‐β in Cholangiocarcinoma

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Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells

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Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions

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