Cited by 240Drug Transport and Resistance MechanismsLiver physiology and pathologyGallbladder and Bile Duct Disorders

Physiology of Cholangiocytes

Open access
Tabibian, James H., Masyuk, Anatoliy I., Masyuk, Tetyana V., O'Hara, Steven P., LaRusso, Nicholas F.·2013·Comprehensive Physiology

Abstract

Cholangiocytes are epithelial cells that line the intra‐ and extrahepatic ducts of the biliary tree. The main physiologic function of cholangiocytes is modification of hepatocyte‐derived bile, an intricate process regulated by hormones, peptides, nucleotides, neurotransmitters, and other molecules through intracellular signaling pathways and cascades. The mechanisms and regulation of bile modification are reviewed herein. © 2013 American Physiological Society.Compr Physiol 3:541‐565, 2013.

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Registry

Crossref · 10.1002/cphy.c120019

Cites

434 of 434 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Polycystic liver disease is a ciliopathy characterized by fluid-filled hepatic cysts that originate from cholangiocytes.

    “polycystic liver disease is a ciliopathy, characterized by the formation of fluid-filled hepatic cysts that originate from cholangiocytes 156.”

    From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [156]

    The Cholangiocyte morphology and ultrastructure section (page unavailable) says that each cholangiocyte has a primary cilium. A search for “polycystic liver disease” found it only in a reference title; searches for ciliopathies and hepatic cysts found no passage stating that the disease is a ciliopathy or that its fluid-filled cysts originate from cholangiocytes. The cited paper’s text therefore does not establish the attributed claim. (LLM, conf=0.76)

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Cites

2 retracted

Flagged first, then by citations

Research works printed but not linked: 1

  1. [93]Francis HL Demorrow S Franchitto A Venter JK Mancinelli RA White MA Meng F Ueno Y Carpino G Renzi A Baker KK Shine HE Francis TC Gaudio E Alpini GD Onori P Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2 +and cAMP-dependent signaling mechanisms Lab Invest 92 282 294 2012 22064319 PMC3293651

Cited by

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Authors
Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F.
Affiliations
Mayo Clinic (US)
Venue
Comprehensive Physiology
Publisher
Wiley
Published
2013-01
Volume
3
Issue
1
Pages
541-565
ISSN
2040-4603 (ISSN-L)
OpenAlex
W1540556705
Cited by
240
References
434
Citations by year
2026: 2 · 2025: 15 · 2024: 23 · 2023: 19 · 2022: 29 · 2021: 21 · 2020: 25 · 2019: 24 · 2018: 21 · 2017: 23 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 4 · 2012: 2
Type
other
Language
en
Open access
Locations
  • Comprehensive physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R01AI089713)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK024031, P30DK084567, R01DK057993)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
Keywords
cholangiocytes, biliary epithelium, biliary tract, hormonal regulation, peptide signaling, nucleotide signaling, neurotransmitters, intracellular signaling
MeSH terms
Animals, Bile, Biliary Tract, Epithelial Cells, Humans, Signal Transduction

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