Physiology of Cholangiocytes
Open accessAbstract
Cholangiocytes are epithelial cells that line the intra‐ and extrahepatic ducts of the biliary tree. The main physiologic function of cholangiocytes is modification of hepatocyte‐derived bile, an intricate process regulated by hormones, peptides, nucleotides, neurotransmitters, and other molecules through intracellular signaling pathways and cascades. The mechanisms and regulation of bile modification are reviewed herein. © 2013 American Physiological Society.Compr Physiol 3:541‐565, 2013.
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Polycystic liver disease is a ciliopathy characterized by fluid-filled hepatic cysts that originate from cholangiocytes.
“polycystic liver disease is a ciliopathy, characterized by the formation of fluid-filled hepatic cysts that originate from cholangiocytes 156.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [156]
The Cholangiocyte morphology and ultrastructure section (page unavailable) says that each cholangiocyte has a primary cilium. A search for “polycystic liver disease” found it only in a reference title; searches for ciliopathies and hepatic cysts found no passage stating that the disease is a ciliopathy or that its fluid-filled cysts originate from cholangiocytes. The cited paper’s text therefore does not establish the attributed claim. (LLM, conf=0.76)
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Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845 · see citing works
Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works
Andrews, T. S., Atif, J., Liu, J. C., Perciani, C. T., Ma, X., Thoeni, C., Slyper, M., Eraslan, G., Segerstolpe, A., Manuel, J., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1854 · Cited by 307 · see citing works
Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works
Sampaziotis, F., Justin, A. W., Tysoe, O. C., Sawiak, S., Godfrey, E. M., Upponi, S. S., Gieseck, R. L., de Brito, M. C., Berntsen, N. L., Gómez-Vázquez, M. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4360 · Cited by 296 · see citing works
Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.004 · Cited by 266 · see citing works
Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation
Poupon, R. (2015) · Hepatology · doi:10.1002/hep.27715 · Cited by 120 · see citing works
Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids
Rimland, C. A., Tilson, S. G., Morell, C. M., Tomaz, R. A., Lu, W., Adams, S. E., Georgakopoulos, N., Otaizo‐Carrasquero, F., Myers, T. G., Ferdinand, J. R., et al. (2021) · Hepatology · doi:10.1002/hep.31252 · Cited by 110 · see citing works
Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi
Xiong, X., Wang, Q., Wang, S., Zhang, J., Liu, T., Guo, L., Yu, Y., & Lin, J. D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2018.12.004 · Cited by 100 · see citing works
Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis
Tabibian, J. H., Talwalkar, J. A., & Lindor, K. D. (2013) · BioMed Research International · doi:10.1155/2013/389537 · Cited by 91 · see citing works
Self-citationVerstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-79082-8 · Cited by 86 · see citing works
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Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes
Desplat, A., Penalba, V., Gros, E., Parpaite, T., Coste, B., & Delmas, P. (2021) · Journal of General Physiology · doi:10.1085/jgp.202112871 · Cited by 38 · see citing works
Frank, A. K., Chung, B. K., De Novales, M. L. L., Engesæter, L. K., Hoyle, H. W., Øgaard, J., Heslop, J., Karlsen, T. H., Tysoe, O., Brevini, T., et al. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08570-y · Cited by 14 · see citing works
- Authors
- Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F.
- Affiliations
- Mayo Clinic (US)
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 3
- Issue
- 1
- Pages
- 541-565
- ISSN
- 2040-4603 (ISSN-L)
- PMC
- PMC3831353
- OpenAlex
- W1540556705
- Cited by
- 240
- References
- 434
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 23 · 2023: 19 · 2022: 29 · 2021: 21 · 2020: 25 · 2019: 24 · 2018: 21 · 2017: 23 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 4 · 2012: 2
- Type
- other
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Comprehensive physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI089713)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK024031, P30DK084567, R01DK057993)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- cholangiocytes, biliary epithelium, biliary tract, hormonal regulation, peptide signaling, nucleotide signaling, neurotransmitters, intracellular signaling
- MeSH terms
- Animals, Bile, Biliary Tract, Epithelial Cells, Humans, Signal Transduction
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