The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Neuroendocrine aspects of hypercortisolism in major depression
Abstract
A consistent finding in biological psychiatry is that hypothalamic-pituitary-adrenal (HPA) axis physiology is altered in humans with major depression. These findings include hypersecretion of cortisol at baseline and on the dexamethasone suppression test. In this review, we present a process-oriented model for HPA axis regulation in major depression. Specifically, we suggest that acute depressions are characterized by hypersecretion of hypothalamic corticotropin-releasing factor, pituitary adrenocorticotropic hormone (ACTH), and adrenal cortisol. In chronic depressions, however, enhanced adrenal responsiveness to ACTH and glucocorticoid negative feedback work in complementary fashion so that cortisol levels remain elevated while ACTH levels are reduced. In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed.
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“The induction of anhedonia has been the primary focus in this model”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [40]
In the citing paper
“has been the most consistent biological abnormality in this disorder [38, 40].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [40]
In the citing paper
“along with its important feature reproducing hypercortisolism, which is found in 40–60% of patients with major depression”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [40]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 2×
“Because depressive episodes are frequently elicited or exacerbated by psychosocial sources of stress (McEwen, 1998; Schatzberg and Nemeroff, 1998), animal research has tended to focus on how stress affects hypothalamic–pituitary–adrenal (HPA) axis physiology and, ultimately, how HPA axis physiology…”
BackgroundPsychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1
Selye, H. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-2-117 · Cited by 2,296
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Paykel, E. S. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740240113014 · Cited by 972
Katz, R. J., Roth, K. A., & Carroll, B. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90005-1 · Cited by 889
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766
Research works printed but not linked: 1
- Kolanowski, 1969, Response of human adrenal cortex to corticotropin, Ann. Endocrinol., 30, 857
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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
The Evolution of the Cognitive Model of Depression and Its Neurobiological Correlates
Beck, A. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08050721 · Cited by 1,537
Holwerda, T. J., Deeg, D. J. H., Beekman, A. T. F., van Tilburg, T. G., Stek, M. L., Jonker, C., & Schoevers, R. A. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302755 · Cited by 633
Metadata
- Authors
- Parker, K. J., Schatzberg, A. F., & Lyons, D. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Parker, Karen J
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 43
- Issue
- 1
- Pages
- 60-66
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2093358121
- Cited by
- 455
- References
- 89
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 18 · 2020: 18 · 2019: 18 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 27 · 2013: 27 · 2012: 22
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- School of Medicine, Stanford University
- National Institute of Mental Health (MH-47573, R01MH050604, MH50604, R01MH047573)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- hypercortisolism, major depressive disorder, hypothalamic-pituitary-adrenal axis, cortisol, corticotropin-releasing factor, ACTH, glucocorticoid negative feedback, dexamethasone suppression test, chronic depression, acute depression, neuroendocrinology
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Corticotropin-Releasing Hormone, Major Depressive Disorder, Humans, Hydrocortisone, Neurosecretory Systems
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