Cited by 455Stress Responses and CortisolAdrenal Hormones and DisordersNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Neuroendocrine aspects of hypercortisolism in major depression

Parker, Karen J, Schatzberg, Alan F, Lyons, David M·2003·Hormones and Behavior

Open this paper in CoChat — free account

Abstract

A consistent finding in biological psychiatry is that hypothalamic-pituitary-adrenal (HPA) axis physiology is altered in humans with major depression. These findings include hypersecretion of cortisol at baseline and on the dexamethasone suppression test. In this review, we present a process-oriented model for HPA axis regulation in major depression. Specifically, we suggest that acute depressions are characterized by hypersecretion of hypothalamic corticotropin-releasing factor, pituitary adrenocorticotropic hormone (ACTH), and adrenal cortisol. In chronic depressions, however, enhanced adrenal responsiveness to ACTH and glucocorticoid negative feedback work in complementary fashion so that cortisol levels remain elevated while ACTH levels are reduced. In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed.

Integrity signals

Registry

Crossref · 10.1016/s0018-506x(02)00016-8

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 2×
“Because depressive episodes are frequently elicited or exacerbated by psychosocial sources of stress (McEwen, 1998; Schatzberg and Nemeroff, 1998), animal research has tended to focus on how stress affects hypothalamic–pituitary–adrenal (HPA) axis physiology and, ultimately, how HPA axis physiology…”
Background
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Stress and Depression
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1
Selye, H. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-2-117 · Cited by 2,296
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Life Events and Depression
Paykel, E. S. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740240113014 · Cited by 972
Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression
Katz, R. J., Roth, K. A., & Carroll, B. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90005-1 · Cited by 889
Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766

Show all 89 references

Research works printed but not linked: 1

Kolanowski, 1969, Response of human adrenal cortex to corticotropin, Ann. Endocrinol., 30, 857

Sorted by citations

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Major depressive disorder
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
The Evolution of the Cognitive Model of Depression and Its Neurobiological Correlates
Beck, A. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08050721 · Cited by 1,537
Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)
Holwerda, T. J., Deeg, D. J. H., Beekman, A. T. F., van Tilburg, T. G., Stek, M. L., Jonker, C., & Schoevers, R. A. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302755 · Cited by 633
HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558
Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study
Singh-Manoux, A., Dugravot, A., Fournier, A., Abell, J., Ebmeier, K., Kivimäki, M., & Sabia, S. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0660 · Cited by 529
Depression and cardiovascular disease in elderly: Current understanding
Zhang, Y., Chen, Y., & Ma, L. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.09.022 · Cited by 514
Human hypothalamus–pituitary–adrenal axis responses to acute psychosocial stress in laboratory settings
Foley, P., & Kirschbaum, C. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.010 · Cited by 455
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 463
Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats
Gregus, A., Wintink, A. J., Davis, A. C., & Kalynchuk, L. E. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.013 · Cited by 458
Neurobiology of chronic mild stress: parallels to major depression
Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420
Biomarkers for depression: recent insights, current challenges and future prospects
Strawbridge, R., Young, A. H., & Cleare, A. J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114542 · Cited by 415
Depression and the Link with Cardiovascular Disease
Dhar, A. K., & Barton, D. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00033 · Cited by 431
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369
Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression
Allen, J., Romay-Tallón, R., Brymer, K. J., Caruncho, H. J., & Kalynchuk, L. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00386 · Cited by 362
Prenatal alcohol exposure: Fetal programming and later life vulnerability to stress, depression and anxiety disorders
Hellemans, K. G. C., Sliwowska, J. H., Verma, P., & Weinberg, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.004 · Cited by 358
Mood, food, and obesity
Singh, M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00925 · Cited by 337
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Chevalier, G., Siopi, E., Guenin‐Macé, L., Pascal, M., Laval, T., Rifflet, A., Boneca, I. G., Demangel, C., Colsch, B., Pruvost, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19931-2 · Cited by 337
Metabolic disturbances connecting obesity and depression
Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: From adaptive responses to psychopathologies
Finsterwald, C., & Alberini, C. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.09.017 · Cited by 330
Depression during pregnancy and postpartum: Contribution of stress and ovarian hormones
Brummelte, S., & Galea, L. A. M. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.006 · Cited by 307
The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior
Conradt, E. D., Lester, B. M., Appleton, A. A., Armstrong, D. A., & Marsit, C. J. (2013) · Epigenetics · doi:10.4161/epi.26634 · Cited by 313
The role of dopamine in bipolar disorder
Cousins, D. A., Butts, K. A., & Young, A. H. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00760.x · Cited by 291
Ovarian Hormone Fluctuation, Neurosteroids, and HPA Axis Dysregulation in Perimenopausal Depression: A Novel Heuristic Model
Gordon, J. L., Girdler, S. S., Meltzer-Brody, S. E., Stika, C. S., Thurston, R. C., Clark, C. T., Prairie, B. A., Moses‐Kolko, E. L., Joffe, H., & Wisner, K. L. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070918 · Cited by 288
Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models
McCormick, C. M., Mathews, I. Z., Thomas, C., & Waters, P. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.003 · Cited by 276
New insights into the role of perinatal HPA-axis dysregulation in postpartum depression
Glynn, L. M., Davis, E. P., & Sandman, C. A. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.007 · Cited by 284
The Hippocampus, Neurotrophic Factors and Depression
Masi, G., & Brovedani, P. (2011) · CNS Drugs · doi:10.2165/11595900-000000000-00000 · Cited by 271
Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression
Sterner, E. Y., & Kalynchuk, L. E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.005 · Cited by 278
Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans
Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248
Hypothalamic-pituitary-adrenal axis and bipolar disorder
Daban, C., Vieta, E., Mackin, P., & Young, A. H. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2005.01.005 · Cited by 245
Positive couple interactions and daily cortisol: On the stress-protecting role of intimacy
Ditzen, B., Hoppmann, C., & Klumb, P. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318185c4fc · Cited by 242
Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults
Liu, R. T., Rowan-Nash, A. D., Sheehan, A. E., Walsh, R. F. L., Sanzari, C. M., Korry, B. J., & Belenky, P. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.026 · Cited by 258
Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation
Leng, L., Zhuang, K., Liu, Z., Huang, C., Gao, Y., Chen, G., Lin, H. Z., Hu, Y., Wu, D., Shi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.031 · Cited by 238
A Time-Dependent History of Mood Disorders in a Murine Model of Neuropathic Pain
Yalçın, İ., Bohren, Y., Waltisperger, E., Ciocca, D., Yin, J. C. P., Freund‐Mercier, M. J., & Barrot, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.017 · Cited by 250
Innovative approaches for the development of antidepressant drugs: Current and future strategies
Schechter, L. E., Ring, R. H., Beyer, C. E., Hughes, Z. A., Khawaja, X. Z., Malberg, J. E., & Rosenzweig-Lipson, S. J. (2005) · NeuroRx · doi:10.1602/neurorx.2.4.590 · Cited by 231
Decreased hippocampal volume in healthy girls at risk of depression
Chen, M. C., Hamilton, J. P., & Gotlib, I. H. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.202 · Cited by 220
PTSD and stress sensitisation: A tale of brain and body
Stam, R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.010 · Cited by 211
Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam
Brummelte, S., & Galea, L. A. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.012 · Cited by 216
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204
Self-citation
Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 208
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197
How Low Socioeconomic Status Affects 2-Year Hormonal Trajectories in Children
Chen, E., Cohen, S., & Miller, G. E. (2009) · Psychological Science · doi:10.1177/0956797609355566 · Cited by 209
Age‐dependent effects of chronic stress on brain plasticity and depressive behavior
Tóth, E., Gersner, R., Wilf‐Yarkoni, A., Raizel, H., Dar, D. E., Richter‐Levin, G., Levit, O., & Zangen, A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05642.x · Cited by 198
High post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: A model of post-partum stress and possible depression
Brummelte, S., Pawluski, J. L., & Galea, L. A. M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.04.008 · Cited by 199
History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease
Geerlings, M. I., den Heijer, T., Koudstaal, P. J., Hofman, A., & Breteler, M. M. B. (2008) · Neurology · doi:10.1212/01.wnl.0000308937.30473.d1 · Cited by 248
Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort–reward-imbalance
Bellingrath, S., Weigl, T., & Kudielka, B. M. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.01.006 · Cited by 192
Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression?
Hill, M. N., & Gorzalka, B. B. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00006 · Cited by 196
Corticosterone Increases Depression-Like Behavior, With Some Effects on Predator Odor-Induced Defensive Behavior, in Male and Female Rats.
Kalynchuk, L. E., Gregus, A., Boudreau, D., & Perrot-Sinal, T. S. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1365 · Cited by 188
Th2 Cytokine Response in Major Depressive Disorder Patients before Treatment
Pavón, L., Sandoval-López, G., Eugenia Hernández, M., Loría, F., Estrada, I., Pérez, M., Moreno, J., Ávila, U., Leff, P., Antón, B., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.014 · Cited by 187
Changes in cortisol and dehydroepiandrosterone in women victims of physical and psychological intimate partner violence
Pico-Alfonso, M. A., Garcia-Linares, M. I., Celda-Navarro, N., Herbert, J., & Martı́nez, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.001 · Cited by 184
Prospective investigation of stress inoculation in young monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.933 · Cited by 185
Self-citation
Hypothalamic–Pituitary–Adrenal Axis Dysregulation in Dysphoric Children and Adolescents: Cortisol Reactivity to Psychosocial Stress from Preschool Through Middle Adolescence
Hankin, B. L., Badanes, L. S., Abela, J. R. Z., & Watamura, S. E. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.004 · Cited by 197
The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants
Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 175
Depression research: where are we now?
Lee, S., Jeong, J., Kwak, Y., & Park, S. K. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-8 · Cited by 187
The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA‐NCAM within the Hippocampus
Wainwright, S. R., & Galea, L. A. M. (2013) · Neural Plasticity · doi:10.1155/2013/805497 · Cited by 169
Preliminary evidence that plasma oxytocin levels are elevated in major depression
Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.017 · Cited by 163
Self-citation
BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders
Qiu, P., Jiang, J., Liu, Z., Cai, Y., Huang, T., Wang, Y., Liu, Q., Nie, Y., Liu, F., Cheng, J., et al. (2019) · National Science Review · doi:10.1093/nsr/nwz002 · Cited by 163
Prenatal Alcohol Exposure Increases Vulnerability to Stress and Anxiety‐Like Disorders in Adulthood
Hellemans, K. G. C., Verma, P., Yoon, E., Yu, W. K., & Weinberg, J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.016 · Cited by 161
Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis)
Shively, C. A., Register, T. C., Friedman, D. P., Morgan, T. M., Thompson, J., & Lanier, T. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.006 · Cited by 158
Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion
Doane, L. D., Mineka, S., Zinbarg, R. E., Craske, M. G., Griffith, J. W., & Adam, E. K. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000060 · Cited by 171
Autobiographic memory impairment following acute cortisol administration
Buß, C., Wolf, O. T., Witt, J., & Hellhammer, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.09.006 · Cited by 156
Pharmacotherapy of PTSD: premises, principles, and priorities.
Ravindran, L. N., & Stein, M. B. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.037 · Cited by 153
Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation
Sasaki, K., Omri, A. E., Kondo, S., Han, J., & Isoda, H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.010 · Cited by 152
Stress: Influence of sex, reproductive status and gender
Rincón‐Cortés, M., Herman, J. P., LUPIEN, S. J., Maguire, J. L., & Shansky, R. M. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100155 · Cited by 161
Food addiction: Prevalence, psychopathological correlates and associations with quality of life in a large sample
Nunes-Neto, P. R., Köhler, C. A., Schuch, F. B., Solmi, M., Quevedo, J., Maes, M., Murru, A., Vieta, E., McIntyre, R. S., McElroy, S. L., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.10.003 · Cited by 150
Effects of Physical Exercise on Depressive Symptoms and Biomarkers in Depression
Archer, T., Josefsson, T., & Lindwall, M. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203245 · Cited by 151
Depressive symptoms can be useful: Self-regulatory and emotional benefits of dysphoric mood in adolescence.
Wrosch, C., & Miller, G. E. (2009) · Journal of Personality and Social Psychology · doi:10.1037/a0015172 · Cited by 143
Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression
Sigwalt, A. R., Budde, H., Helmich, I., Glaser, V., Ghisoni, K., Lanza, S. R., Cadore, E. L., Lhullier, F. L. R., Bem, A. F. D., Hohl, A., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.075 · Cited by 147
The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development
Ring, R. H. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382241 · Cited by 142
Stress, Memory, and the Hippocampus
Wingenfeld, K., & Wolf, O. T. (2014) · Frontiers of Neurology and Neuroscience · doi:10.1159/000356423 · Cited by 139
Epigenetic programming of the neuroendocrine stress response by adult life stress
Dirven, B. C. J., Homberg, J. R., Kozicz, T., & Henckens, M. J. A. G. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0019 · Cited by 135
Prenatal Alcohol Exposure and Chronic Mild Stress Differentially Alter Depressive‐ and Anxiety‐Like Behaviors in Male and Female Offspring
Hellemans, K. G. C., Verma, P., Yoon, E., Yu, W. K., Young, A. H., & Weinberg, J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01132.x · Cited by 133
Machine Learning-Based Predictive Modeling of Postpartum Depression
Shin, D., Lee, K. J., Adeluwa, T., & Hur, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092899 · Cited by 144
What Sleeping Babies Hear
Graham, A. M., Fisher, P. A., & Pfeifer, J. H. (2013) · Psychological Science · doi:10.1177/0956797612458803 · Cited by 133
The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning
Conradt, E. D., Hawes, K., Guerin, D. J., Armstrong, D. A., Marsit, C. J., Tronick, E. Z., & Lester, B. M. (2016) · Child Development · doi:10.1111/cdev.12483 · Cited by 126
Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: Results from the Health ABC study
Morsink, L., Vogelzangs, N., Nicklas, B. J., Beekman, A. T. F., Satterfield, S., Rubin, S. M., Yaffe, K. S., Simonsick, E. M., Newman, A. B., Kritchevsky, S. B., et al. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.06.009 · Cited by 125
Evidence that Stress Contributes to Inflammatory Bowel Disease: Evaluation, Synthesis, and Future Directions
Maunder, R. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000161919.42878.a0 · Cited by 125
A neural pathway controlling motivation to exert effort
Proulx, C. D., Aronson, S., Milivojevic, D., Molina, C., Loi, A., Monk, B., Shabel, S. J., & Malinow, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801837115 · Cited by 119
Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 120
Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis
Hill, M. N., Ho, W. ‐. V., Sinopoli, K. J., Viau, V., Hillard, C. J., & Gorzalka, B. B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301092 · Cited by 118
Changes in hypothalamic–pituitary–adrenal axis measures after vagus nerve stimulation therapy in chronic depression
O’Keane, V., Dinan, T. G., Scott, L., & Corcoran, C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.049 · Cited by 111
Clinical burnout is not reflected in the cortisol awakening response, the day curve or the response to a low-dose dexamethasone suppression test
Mommersteeg, P. M. C., Heijnen, C. J., Verbraak, M. J. P. M., & van Doornen, L. J. P. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.07.003 · Cited by 111
The Metabolic Syndrome in Patients With Severe Mental Illnesses
Toalson, P. A., Ahmed, S., Hardy, T. A., & Kabinoff, G. S. (2004) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v06n0402 · Cited by 106
Open questions in current models of antidepressant action
Tanti, A., & Belzung, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00585.x · Cited by 115
Hormone seasonality in medical records suggests circannual endocrine circuits
Tendler, A., Bar, A., Cohen, N. M., Karin, O., Kohanim, Y. K., Maimon, L., Milo, T., Raz, M., Mayo, A., Tanay, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003926118 · Cited by 106
Cardiovascular Abnormalities in Patients with Major Depressive Disorder
Brown, A. D. H., Barton, D. A., & Lambert, G. W. (2009) · CNS Drugs · doi:10.2165/00023210-200923070-00004 · Cited by 111
Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
Parker, K. J., Buckmaster, C. L., Justus, K. R., Schatzberg, A. F., & Lyons, D. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.024 · Cited by 109
Self-citation
Future Directions in Vulnerability to Depression Among Youth: Integrating Risk Factors and Processes Across Multiple Levels of Analysis
Hankin, B. L. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.711708 · Cited by 123
Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations
Malisch, J. L., Breuner, C. W., Kolb, E. M., Wada, H., Hannon, R. M., Chappell, M. A., Middleton, K. M., & Garland, T. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9246-8 · Cited by 107
Maternal Deprivation Induces Depressive-like Behaviour and Alters Neurotrophin Levels in the Rat Brain
Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Cipriano, A. L., Panizzutti, B., Stertz, L., Lersch, C., Kapczinski, F. P., & Quevedo, J. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0364-3 · Cited by 111
How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation
Liu, P. Z., & Nusslock, R. (2017) · Current Genomics · doi:10.2174/1389202919666171228164350 · Cited by 111
Glucocorticoids and Hippocampal Structure and Function in PTSD
Szeszko, P. R., Lehrner, A. L., & Yehuda, R. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000188 · Cited by 112
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 138
Brain foods - the role of diet in brain performance and health
Ekstrand, B., Scheers, N., Rasmussen, M. K., Young, J. F., Ross, A. B., & Landberg, R. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa091 · Cited by 115
Glucocorticoid Receptor Polymorphisms in Major Depression
Spijker, A. T., & van Rossum, E. F. C. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04985.x · Cited by 101
Neuronal nitric oxide synthase and affective disorders
Zhou, Q., Zhu, X., Nemes, A. D., & Zhu, D. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.11.004 · Cited by 101
Associations between HPA axis functioning and level of anxiety in children and adolescents with an anxiety disorder
Kallen, V., Tulen, J. H. M., Utens, E. M. W. J., Treffers, P. D. A., de Jong, F. H., & Ferdinand, R. F. (2007) · Depression and Anxiety · doi:10.1002/da.20287 · Cited by 101
Exhaustion and endocrine functioning in clinical burnout: An in-depth study using the experience sampling method
Sonnenschein, M., Mommersteeg, P. M. C., Houtveen, J. H., Sorbi, M. J., Schaufeli, W. B., & van Doornen, L. J. P. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.02.001 · Cited by 106
Depression and functional outcome in patients with brain tumors: a population-based 1-year follow-up study
Mainio, A., Hakko, H. H., Niemelä, A., Koivukangas, J. P., & Räsänen, P. K. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.103.5.0841 · Cited by 102

Authors: Parker, K. J., Schatzberg, A. F., & Lyons, D. M.
Affiliations: Stanford Medicine (US)
Corresponding author: Parker, Karen J
ORCID: Parker, Karen J
Schatzberg, Alan F
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2003-01
Volume: 43
Issue: 1
Pages: 60-66
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/s0018-506x(02)00016-8
OpenAlex: W2093358121
Cited by: 455
References: 89
Citations by year: 2026: 8 · 2025: 4 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 18 · 2020: 18 · 2019: 18 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 27 · 2013: 27 · 2012: 22
FWCI: 7.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: School of Medicine, Stanford University
National Institute of Mental Health (MH-47573, R01MH050604, MH50604, R01MH047573)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: hypercortisolism, major depressive disorder, hypothalamic-pituitary-adrenal axis, cortisol, corticotropin-releasing factor, ACTH, glucocorticoid negative feedback, dexamethasone suppression test, chronic depression, acute depression, neuroendocrinology
MeSH terms: Adrenocorticotropic Hormone, Animals, Corticotropin-Releasing Hormone, Major Depressive Disorder, Humans, Hydrocortisone, Neurosecretory Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroendocrine aspects of hypercortisolism in major depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks