Application of BMP-7 to tibial non-unions: A 3-year multicenter experience
Abstract
Summary The effective treatment of the often debilitating, longlasting and large-asset-consuming complication of fracture non-unions has been in the centre of scientific interest the last decades. The use of alternative bone substitutes to the gold standard of autologous graft includes the osteoinductive molecules named bone morphogenetic proteins (BMPs). A multicenter registry and database (bmpusergroup.co.uk) focused on the application of BMP-7/OP-1 was created in December 2005. We present the preliminary results, using the prospective case-series of aseptic tibial non-unions as an example. Sixty-eight patients fulfilled the inclusion criteria for this observational study, with a minimum follow-up of 12 months. The median duration of tibial non-union prior to BMP-7 application was 23 months (range 9-317 mo). Patients had undergone a median of 2 (range 0-11) revision procedures prior to the administration of BMP-7. In 41% the application of BMP-7 was combined with revision of the fixation at the non-union site. Non-union healing was verified in 61 (89.7%) in a median period of 6.5 months (range 3-15 mo). No adverse events or complications were associated with BMP-7 application. The safety and efficacy of BMP-7 was verified in our case series, and was comparable to the existing evidence. The establishment of multicenter networks and the systematic and long-term follow- up of these patients are expected to provide further information and significantly improve our understanding of this promising osteoinductive bone substitute.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The family of BMPs plays a crucial role in inducing osteogenesis.
“The family of BMPs plays a crucial role in inducing osteogenesis.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 are vital for bone formation and repair, with applications in open tibial fractures and non-unions.
“BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 are vital for bone formation and repair, with applications in open tibial fractures and non-unions [39,69,70,79].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
Cites
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736 · see citing works
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529 · see citing works
Problems in the Management of Type III (Severe) Open Fractures
Gustilo, R. B., Mendoza, R. M., & Williams, D. N. (1984) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198408000-00009 · Cited by 2,394 · see citing works
Morbidity at Bone Graft Donor Sites
Younger, E. W., & Chapman, M. W. (1989) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-198909000-00002 · Cited by 2,020 · see citing works
GOVENDER, S., CSIMMA, C., GENANT, H. K., & VALENTIN-OPRAN, A. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200212000-00001 · Cited by 1,308 · see citing works
Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions
Friedlaender, G. E., Perry, C. R., Cole, J. D., Cook, S. D., Cierný, G., Muschler, G. F., Zych, G. A., Calhoun, J. H., LaForte, A. J., & Yin, S. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200100002-00010 · Cited by 956 · see citing works
Autogenous Iliac Crest Bone Graft: Complications and Functional Assessment
Goulet, J. A., Senunas, L. E., DeSilva, G. L., & Greenfield, M. L. V. H. (1997) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199706000-00011 · Cited by 911 · see citing works
Purification and characterization of other distinct bone-inducing factors.
Wang, E. A., Rosen, V., Cordes, P., Hewick, R. M., Kriz, M. J., Luxenberg, D. P., Sibley, B. S., & Wozney, J. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9484 · Cited by 614 · see citing works
Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions?
Sen, M., & Miclau, T. (2007) · Injury · doi:10.1016/j.injury.2007.02.012 · Cited by 547 · see citing works
Nonunion of the femoral diaphysis
Giannoudis, P. V., MacDonald, D. A., Matthews, S. J., Smith, R. M., Furlong, A. J., & de Boer, P. (2000) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.82b5.9899 · Cited by 413 · see citing works
Self-citationSafety Profile for the Clinical Use of Bone Morphogenetic Proteins in the Spine
Poynton, A. R., & Lane, J. M. (2002) · Spine · doi:10.1097/00007632-200208151-00010 · Cited by 403 · see citing works
Castillo, R. C., Bosse, M. J., MacKenzie, E. J., & Patterson, B. M. (2005) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-200503000-00001 · Cited by 400 · see citing works
Garrison, K. R., Donell, S. T., Ryder, J. J., Shemilt, I., Mugford, M., Harvey, I. M., & Song, F. (2007) · Health Technology Assessment · doi:10.3310/hta11300 · Cited by 340 · see citing works
Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures
Starr, A. J. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200310000-00027 · Cited by 297 · see citing works
Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
White, A. P., Vaccaro, A. R., Hall, J. A., Whang, P. G., Friel, B. C., & McKee, M. D. (2007) · International Orthopaedics · doi:10.1007/s00264-007-0422-x · Cited by 270 · see citing works
The health economics of the treatment of long-bone non-unions
Kanakaris, N. K., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80012-x · Cited by 256 · see citing works
Self-citationMegas, P. (2005) · Injury · doi:10.1016/j.injury.2005.10.008 · Cited by 249 · see citing works
Growth factor stimulation of bone healing
Lind, M. (1998) · Acta Orthopaedica Scandinavica · doi:10.1080/17453674.1998.11744808 · Cited by 213 · see citing works
Termaat, M. F. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02585 · Cited by 210 · see citing works
Immune Responses to Allogeneic and Xenogeneic Implants of Collagen and Collagen Derivatives
Delustro, F. A., Dasch, J. R., Keefe, J., & Ellingsworth, L. R. (1990) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199011000-00043 · Cited by 210 · see citing works
Exchange Nailing of Ununited Fractures
Brinker, M. R., & O’Connor, D. P. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200701000-00025 · Cited by 197 · see citing works
Resistant Nonunions and Partial or Complete Segmental Defects of Long Bones
Johnson, E. E., Urist, M. R., & Finerman, G. A. M. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199204000-00028 · Cited by 189 · see citing works
Boskey, A. L., DiCarlo, E. F., Paschalis, E. P., West, P. A., & Mendelsohn, R. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1992-3 · Cited by 187 · see citing works
Biase, P. D., & Capanna, R. (2005) · Injury · doi:10.1016/j.injury.2005.07.034 · Cited by 172 · see citing works
Self-citationFemoral Nonunion: Risk Factors and Treatment Options
Lynch, J. R., Taitsman, L. A., Barei, D. P., & Nork, S. E. (2008) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200802000-00006 · Cited by 166 · see citing works
Phieffer, L. S., & Goulet, J. A. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200601000-00026 · Cited by 162 · see citing works
Application of recombinant BMP-7 on persistent upper and lower limb non-unions
Dimitriou, R. I., Dahabreh, Z., Katsoulis, E., Matthews, S. J., Branfoot, T., & Giannoudis, P. V. (2005) · Injury · doi:10.1016/j.injury.2005.10.010 · Cited by 151 · see citing works
Self-citationSeven Yearsʼ Experience With Integra as a Reconstructive Tool
Jeng, J. C., Fidler, P. E., Sokolich, J. C., Jaskille, A. D., Khan, S., White, P. M., Street, J. H., Light, T. D., & Jordan, M. H. (2007) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31802cb83f · Cited by 130 · see citing works
Nonsteroidal Anti-Inflammatory Drug-Induced Fracture Nonunion: An Inhibition of Angiogenesis?
Murnaghan, M., Li, G., & Marsh, D. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00454 · Cited by 127 · see citing works
Johnson, E. E., Urist, M. R., & Finerman, G. A. M. (1990) · PubMed · Cited by 127 · see citing works
Laursen, M., Høy, K., Hansen, E. S., Gelineck, J., Christensen, F. B., & Bünger, C. E. (1999) · European Spine Journal · doi:10.1007/s005860050210 · Cited by 123 · see citing works
Niikura, T., Hak, D. J., & Reddi, A. H. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20182 · Cited by 113 · see citing works
Dahabreh, Z., Dimitriou, R. I., & Giannoudis, P. V. (2006) · Injury · doi:10.1016/j.injury.2006.08.055 · Cited by 110 · see citing works
Self-citationGiannoudis, P. V., Kanakaris, N. K., & Einhorn, T. A. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0441-x · Cited by 108 · see citing works
Self-citationUse of Bone Morphogenetic Proteins for Musculoskeletal Applications
Mont, M. A., Ragland, P. S., Biggins, B., Friedlaender, G. E., Patel, T. C., Cook, S. D., Etienne, G., Shimmin, A., Kildey, R., Rueger, D. C., et al. (2004) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200412002-00008 · Cited by 106 · see citing works
Use of bone morphogenetic proteins for treatment of non-unions and future perspectives
Schmidmaier, G., Schwabe, P., Wildemann, B., & Haas, N. P. (2007) · Injury · doi:10.1016/s0020-1383(08)70007-x · Cited by 100 · see citing works
Vascularised bone grafts for the management of non-union
Soucacos, P. N., Dailiana, Z. H., Beris, A. E., & Johnson, E. O. (2006) · Injury · doi:10.1016/j.injury.2006.02.040 · Cited by 85 · see citing works
Kanakaris, N. K., Paliobeis, C. P., Manidakis, N., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80011-8 · Cited by 78 · see citing works
Self-citationAvailable biological treatments for complex non-unions
Mahendra, A., & MacLean, A. K. (2007) · Injury · doi:10.1016/s0020-1383(08)70004-4 · Cited by 77 · see citing works
Tibial Nonunion: Treatment Alternatives
Wiss, D. A., & Stetson, W. B. (1996) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-199609000-00003 · Cited by 76 · see citing works
Bone morphogenic protein and its application in trauma cases: A current concept update
Bagaria, V. B., Patil, N., Vikram, S., & Chadda, A. (2007) · Injury · doi:10.1016/j.injury.2006.12.012 · Cited by 73 · see citing works
Giannoudis, P. V., Psarakis, S. A., Kanakaris, N. K., & Pape, H. (2007) · Injury · doi:10.1016/s0020-1383(08)70008-1 · Cited by 71 · see citing works
Self-citationGriffin, X. L., Warner, F., & Costa, M. L. (2008) · Injury · doi:10.1016/j.injury.2007.12.014 · Cited by 67 · see citing works
Are there advances in the treatment of extracapsular hip fractures in the elderly?
STERN, R. E. (2007) · Injury · doi:10.1016/j.injury.2007.08.015 · Cited by 67 · see citing works
Calori, G. M., D’Avino, M., Tagliabue, L., Albisetti, W., d’Imporzano, M., & Peretti, G. (2006) · Injury · doi:10.1016/j.injury.2006.08.023 · Cited by 66 · see citing works
Self-citationRonga, M., Baldo, F., Zappalà, G., & Cherubino, P. (2006) · Injury · doi:10.1016/j.injury.2006.08.024 · Cited by 65 · see citing works
Self-citationApplication of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effects
Harwood, P. J., & Giannoudis, P. V. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.1.75 · Cited by 64 · see citing works
Self-citationSzpalski, M., & Gunzburg, R. (2005) · PubMed · Cited by 62 · see citing works
Discovery and development of BMPs
Dimitriou, R. I., & Giannoudis, P. V. (2005) · Injury · doi:10.1016/j.injury.2005.07.031 · Cited by 62 · see citing works
Self-citationLong term results of compartment syndrome of the lower limb in polytraumatised patients
Frink, M., Klaus, A.-K., Küther, G., Probst, C. P., Gösling, T., Kobbe, P., Hildebrand, F., Richter, M., Giannoudis, P. V., Krettek, C., et al. (2007) · Injury · doi:10.1016/j.injury.2006.12.021 · Cited by 61 · see citing works
Self-citationFemoral diaphyseal aseptic non-unions: Is there an ideal method of treatment?
Crowley, D. J., Kanakaris, N. K., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80010-6 · Cited by 57 · see citing works
Self-citationManagement of nonunion with distraction osteogenesis
Kanellopoulos, A. D., & Soucacos, P. N. (2006) · Injury · doi:10.1016/j.injury.2006.02.041 · Cited by 57 · see citing works
Kärrholm, J., Hourigan, P. G., Timperley, J. A., & Razaznejad, R. (2006) · Acta Orthopaedica · doi:10.1080/17453670610045687 · Cited by 52 · see citing works
Mechanical and biological treatment of long bone non-unions
Biasibetti, A., Aloj, D. C., Gregorio, G. D., Massè, A., & Salomone, C. (2005) · Injury · doi:10.1016/j.injury.2005.10.013 · Cited by 50 · see citing works
Therapieerfolg bei atrophen Tibiaschaftpseudarthrosen
Zimmermann, G., Müller, U., Löffler, C., Wentzensen, A., & Moghaddam, A. (2007) · Der Unfallchirurg · doi:10.1007/s00113-007-1347-y · Cited by 41 · see citing works
Electric stimulation and hyperbaric oxygen therapy in the treatment of nonunions
Karamitros, A., Kalentzos, V. N., & Soucacos, P. N. (2006) · Injury · doi:10.1016/j.injury.2006.02.042 · Cited by 36 · see citing works
Osteogenic protein-1 in treatment of tibial nonunions: current status.
Friedlaender, G. E. (2004) · PubMed · Cited by 30 · see citing works
Transcriptomics and proteomics: Advancing the understanding of genetic basis of fracture healing
Tsiridis, E. E., & Giannoudis, P. V. (2006) · Injury · doi:10.1016/j.injury.2006.02.036 · Cited by 28 · see citing works
Self-citationNilsson, O., & Urist, M. R. (1991) · International Orthopaedics · doi:10.1007/bf00192304 · Cited by 27 · see citing works
Immunologic evidence of a bone morphogenetic protein in the milieu intérieur.
Mr, U., NILSSON, O. S., Hudak, R., Huo, Y. K., Rasmussen, J., Hirota, W. K., & Lietze, A. (1985) · PubMed · Cited by 27 · see citing works
Biotherapeutics in Orthopaedic Medicine
Puleo, D. A. (2003) · BioDrugs · doi:10.2165/00063030-200317050-00001 · Cited by 13 · see citing works
Engen, A. V., & Vinken, A. (2002) · Value in Health · doi:10.1016/s1098-3015(10)61523-9 · Cited by 5 · see citing works
Flagged first, then by citations
3 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Bone grafts and biomaterials substitutes for bone defect repair: A review
Wang, W., & Yeung, K. (2017) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.05.007 · Cited by 1,972 · see citing works
The use of bone-graft substitutes in large bone defects: Any specific needs?
Calori, G. M., Mazza, E., Colombo, M., & Ripamonti, C. (2011) · Injury · doi:10.1016/j.injury.2011.06.011 · Cited by 435 · see citing works
Self-citationThe decisive early phase of bone regeneration
Duda, G. N., Geißler, S., Checa, S., Tsitsilonis, S., Petersen, A., & Schmidt‐Bleek, K. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00887-0 · Cited by 417 · see citing works
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390 · see citing works
A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones
Reichert, J. C., Cipitria, A., Epari, D. R., Saifzadeh, S., Krishnakanth, P., Berner, A., Woodruff, M. A., Schell, H., Mehta, M., Schuetz, M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003720 · Cited by 364 · see citing works
Mechanisms of bone repair and regeneration
Deschaseaux, F., Sensebé, L., & Heymann, D. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.07.002 · Cited by 322 · see citing works
Studies of bone morphogenetic protein-based surgical repair
Lo, K. W. ‐., Ulery, B. D., Ashe, K. M., & Laurencin, C. T. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.014 · Cited by 249 · see citing works
Gothard, D., Smith, E. L., Kanczler, J. M., Rashidi, H., Qutachi, O., Henstock, J. R., Rotherham, M., Haj, A. E., Shakesheff, K. M., & Oreffo, R. O. C. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a13 · Cited by 190 · see citing works
Signaling Pathways in Cartilage Repair
Mariani, E., Pulsatelli, L., & Facchini, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058667 · Cited by 169 · see citing works
Incidence of donor site morbidity following harvesting from iliac crest or RIA graft
Calori, G. M., Colombo, M., Mazza, E. L., Mazzola, S., Malagoli, E., & Mineo, G. V. (2014) · Injury · doi:10.1016/j.injury.2014.10.034 · Cited by 169 · see citing works
Self-citationCurrent management of long bone large segmental defects
Lasanianos, N. G., Kanakaris, N. K., & Giannoudis, P. V. (2010) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2009.10.003 · Cited by 167 · see citing works
Self-citationValidation of the Non-Union Scoring System in 300 long bone non-unions
Calori, G. M., Colombo, M., Mazza, E. L., Mazzola, S., Malagoli, E., Marelli, N., & Corradi, A. (2014) · Injury · doi:10.1016/j.injury.2014.10.030 · Cited by 162 · see citing works
Self-citationDahabreh, Z., Calori, G. M., Kanakaris, N. K., Nikolaou, V. S., & Giannoudis, P. V. (2008) · International Orthopaedics · doi:10.1007/s00264-008-0709-6 · Cited by 142 · see citing works
Self-citationSpatial regulation of controlled bioactive factor delivery for bone tissue engineering
Samorezov, J. E., & Alsberg, E. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.11.018 · Cited by 139 · see citing works
Crouzier, T., Sailhan, F., Becquart, P., Guillot, R., Logeart‐Avramoglou, D., & Picart, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.062 · Cited by 139 · see citing works
The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions
Giannoudis, P. V., Kanakaris, N. K., Dimitriou, R. I., Gill, I. R., Kolimarala, V. K., & Montgomery, R. J. (2009) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-009-0846-2 · Cited by 133 · see citing works
Self-citationChen, F., An, Y., Zhang, R., & Zhang, M. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.021 · Cited by 130 · see citing works
Long bone non-unions treated with the diamond concept: a case series of 64 patients
Giannoudis, P. V., Gudipati, S., Harwood, P. J., & Kanakaris, N. K. (2015) · Injury · doi:10.1016/s0020-1383(15)30055-3 · Cited by 125 · see citing works
Self-citationSanto, V. E., Gomes, M. E., Mano, J. F., & Reis, R. L. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0727 · Cited by 122 · see citing works
Moghaddam, A., Zietzschmann, S., Bruckner, T. M., & Schmidmaier, G. (2015) · Injury · doi:10.1016/s0020-1383(15)30017-6 · Cited by 120 · see citing works
Treatment of long bone non-unions with polytherapy: Indications and clinical results
Calori, G. M., Mazza, E. L., Colombo, M., Ripamonti, C. I., & Tagliabue, L. (2011) · Injury · doi:10.1016/j.injury.2011.03.046 · Cited by 118 · see citing works
Self-citationSenta, H., Park, H., Bergeron, E., Drevelle, O., Fong, D. W. F., Leblanc, É., Cabana, F., Roux, S., Grenier, G., & Faucheux, N. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.05.006 · Cited by 117 · see citing works
Clinical application of bone morphogenetic proteins for bone healing: a systematic review
Krishnakumar, G. S., Roffi, A., Reale, D., Kon, E., & Filardo, G. (2017) · International Orthopaedics · doi:10.1007/s00264-017-3471-9 · Cited by 107 · see citing works
Application of bone morphogenetic proteins to femoral non-unions: A 4-year multicentre experience
Kanakaris, N. K., Lasanianos, N. G., Calori, G. M., Verdonk, R. E., Blokhuis, T. J., Cherubino, P., Biase, P. D., & Giannoudis, P. V. (2009) · Injury · doi:10.1016/s0020-1383(09)70013-0 · Cited by 104 · see citing works
Self-citationClinical applications of growth factors in bone injuries: Experience with BMPs
Ronga, M., Fagetti, A., Canton, G., Paiusco, E., Surace, M. F., & Cherubino, P. (2013) · Injury · doi:10.1016/s0020-1383(13)70008-1 · Cited by 103 · see citing works
Self-citationCalori, G. M. (2017) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2017.14.1.186 · Cited by 103 · see citing works
Self-citationNew findings in osteoarthritis pathogenesis: therapeutic implications
Pulsatelli, L., Addimanda, O., Brusi, V., Pavloska, B., & Meliconi, R. (2013) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622312462734 · Cited by 96 · see citing works
Bone morphogenetic proteins in orthopaedic trauma surgery
Argintar, E. H., Edwards, S. G., & Delahay, J. N. (2010) · Injury · doi:10.1016/j.injury.2010.11.016 · Cited by 90 · see citing works
Treatment of long bone defects and non-unions: from research to clinical practice
Berner, A., Reichert, J. C., Müller, M. B., Zellner, J., Pfeifer, C., Dienstknecht, T., Nerlich, M. L., Sommerville, S. M. M., Dickinson, I. C., Schütz, M. A., et al. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1184-8 · Cited by 91 · see citing works
Marongiu, G., Dolci, A., Verona, M., & Capone, A. (2020) · Bone Reports · doi:10.1016/j.bonr.2020.100249 · Cited by 81 · see citing works
Bosemark, P., Isaksson, H., McDonald, M. M., Little, D. G., & Tägil, M. (2013) · Acta Orthopaedica · doi:10.3109/17453674.2013.773123 · Cited by 80 · see citing works
Growth factors and bone regeneration: How much bone can we expect?
Nauth, A., Ristevski, B., Li, R., & Schemitsch, E. H. (2011) · Injury · doi:10.1016/j.injury.2011.03.034 · Cited by 80 · see citing works
Bone morphogenetic proteins and tissue engineering: future directions
Calori, G. M., Donati, D. M., Bella, C. D., & Tagliabue, L. (2009) · Injury · doi:10.1016/s0020-1383(09)70015-4 · Cited by 77 · see citing works
Self-citationAutograft versus BMPs for the treatment of non-unions: What is the evidence?
Blokhuis, T. J., Calori, G. M., & Schmidmaier, G. (2013) · Injury · doi:10.1016/s0020-1383(13)70009-3 · Cited by 77 · see citing works
Self-citationBone morphogenetic proteins in critical-size bone defects: what are the options?
Schmidmaier, G., Capanna, R., Wildemann, B., Beque, T., & Lowenberg, D. W. (2009) · Injury · doi:10.1016/s0020-1383(09)70010-5 · Cited by 76 · see citing works
Self-citationThe Potential Impact of Bone Tissue Engineering in the Clinic
Mishra, R., Bishop, T. J., Valerio, I. L., Fisher, J. P., & Dean, D. (2016) · Regenerative Medicine · doi:10.2217/rme-2016-0042 · Cited by 72 · see citing works
Bone morphogenetic proteins in musculoskeletal medicine
Giannoudis, P. V., & Einhorn, T. A. (2009) · Injury · doi:10.1016/s0020-1383(09)00642-1 · Cited by 70 · see citing works
Self-citationExchange nailing for nonunion of diaphyseal fractures of the tibia
Tsang, S. J., Mills, L. A., Frantzias, J., Baren, J. P., Keating, J. F., & Simpson, H. (2016) · The Bone & Joint Journal · doi:10.1302/0301-620x.98b4.34870 · Cited by 69 · see citing works
Bone Graft Substitution and Augmentation
Nauth, A., Lane, J. M., Watson, J. T., & Giannoudis, P. V. (2015) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000000464 · Cited by 65 · see citing works
Self-citationHaffner, N., Antonic, V., Smolen, D., Slezak, P., Schaden, W., Mittermayr, R., & Stojadinovic, A. (2016) · Injury · doi:10.1016/j.injury.2016.04.010 · Cited by 61 · see citing works
BMP-7 Versus BMP-2 for the Treatment of Long Bone Nonunion
Conway, J. D., Shabtai, L., Bauernschub, A., & Specht, S. C. (2014) · Orthopedics · doi:10.3928/01477447-20141124-50 · Cited by 59 · see citing works
Simple Signaling Molecules for Inductive Bone Regenerative Engineering
Cushnie, E. K., Ulery, B. D., Nelson, S. J., Deng, M., Sethuraman, S., Doty, S. B., Lo, K. W. ‐., Khan, Y., & Laurencin, C. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101627 · Cited by 57 · see citing works
Core decompression and biotechnologies in the treatment of avascular necrosis of the femoral head
Calori, G. M., Mazza, E. L., Colombo, A. I. M., Mazzola, S., & Colombo, M. (2017) · EFORT Open Reviews · doi:10.1302/2058-5241.2.150006 · Cited by 55 · see citing works
Self-citationStimulation of Bone Healing by Sustained Bone Morphogenetic Protein 2 (BMP-2) Delivery
Fassbender, M., Minkwitz, S., Strobel, C., Schmidmaier, G., & Wildemann, B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058539 · Cited by 52 · see citing works
Gao, R., Watson, M., Callon, K. E., Tuari, D., Dray, M. S., Naot, D., Amirapu, S., Munro, J. T., Cornish, J., & Musson, D. S. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2348 · Cited by 52 · see citing works
Bergeron, E., Leblanc, E., Drevelle, O., Giguère, R., Beauvais, S., Grenier, G., & Faucheux, N. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0008 · Cited by 51 · see citing works
Is there a role for bone morphogenetic proteins in osteoporotic fractures?
Kanakaris, N. K., Petsatodis, G. E., Tägil, M., & Giannoudis, P. V. (2009) · Injury · doi:10.1016/s0020-1383(09)70007-5 · Cited by 47 · see citing works
Self-citationLimb reconstruction after traumatic bone loss
Chimutengwende-Gordon, M., Abubaker, M., Khan, W. S., & Wilkes, R. A. (2013) · Injury · doi:10.1016/j.injury.2013.11.022 · Cited by 46 · see citing works
Hao, Z., Zhang, Z., Wang, Z.-P., Wang, Y., Chen, J., Chen, T.-H., Shi, G., Li, H., Wang, J.-W., Dong, M.-C., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00576-x · Cited by 50 · see citing works
Ollivier, M. P., Gay, A., Cerlier, A., Lunebourg, A., Argenson, J., & Parratte, S. (2015) · Injury · doi:10.1016/j.injury.2015.03.036 · Cited by 44 · see citing works
Monotherapy vs. polytherapy in the treatment of forearm non-unions and bone defects
Calori, G. M., Colombo, M., Mazza, E. L., Ripamonti, C. I., Mazzola, S., Marelli, N., & Mineo, G. V. (2013) · Injury · doi:10.1016/s0020-1383(13)70015-9 · Cited by 43 · see citing works
Self-citationLaflamme, C., Curt, S., & Rouabhia, M. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2010.06.010 · Cited by 43 · see citing works
Use of bone morphogenetic proteins in arthrodesis: Clinical results
Kanakaris, N. K., Mallina, R. K., Calori, G. M., Kontakis, G. M., & Giannoudis, P. V. (2009) · Injury · doi:10.1016/s0020-1383(09)70014-2 · Cited by 41 · see citing works
Self-citationMegaprosthesis in large bone defects: Opportunity or chimaera?
Calori, G. M., Colombo, M., Ripamonti, C. I., Malagoli, E., Mazza, E. L., Fadigati, P., & Bucci, M. S. (2013) · Injury · doi:10.1016/j.injury.2013.09.015 · Cited by 39 · see citing works
Self-citationCurrent treatment of infected non-union after intramedullary nailing
Simpson, H., & Tsang, S. J. (2017) · Injury · doi:10.1016/j.injury.2017.04.026 · Cited by 39 · see citing works
RhBMP-7 for the treatment of nonunion of fractures of long bones
Papanagiotou, M., Dailiana, Z. H., Karachalios, T. S., Varitimidis, S. E., Vlychou, M., Hantes, M. E., & Malizos, Κ. Ν. (2015) · The Bone & Joint Journal · doi:10.1302/0301-620x.97b7.35089 · Cited by 38 · see citing works
Calori, G. M., Mazza, E. L., Colombo, M., Mazzola, S., Mineo, G. V., & Giannoudis, P. V. (2013) · Injury · doi:10.1016/j.injury.2013.09.014 · Cited by 35 · see citing works
Self-citationUpper limb non-unions treated with BMP-7: efficacy and clinical results
SINGH, R. K., Bleibleh, S., Kanakaris, N. K., & Giannoudis, P. V. (2016) · Injury · doi:10.1016/s0020-1383(16)30837-3 · Cited by 35 · see citing works
Self-citationBone morphogenetic protein signaling and arthritis
Lories, R. J. U., & Luyten, F. P. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.009 · Cited by 32 · see citing works
Clinical effectiveness of Osigraft in long-bones non-unions
Calori, G. M., Colombo, M., Bucci, M. S., Mazza, E. L., Fadigati, P., & Mazzola, S. (2015) · Injury · doi:10.1016/s0020-1383(15)30056-5 · Cited by 31 · see citing works
Self-citationInfluence of implant properties and local delivery systems on the outcome in operative fracture care
Metsemakers, W., Moriarty, T. F., Nijs, S., Pape, H., & Richards, R. G. (2016) · Injury · doi:10.1016/j.injury.2016.01.019 · Cited by 31 · see citing works
Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2
Wigner, N. A., Luderer, H. F., Cox, M. K., Sooy, K., Gerstenfeld, L. C., & Demay, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.091021 · Cited by 31 · see citing works
Bone morphogenetic protein and orthopaedic surgery: Can we legitimate its off-label use?
From the French Study Group of BMP in Orthopedic Surgery, Courvoisier, A., Sailhan, F., Laffenetre, O., & Obert, L. (2014) · International Orthopaedics · doi:10.1007/s00264-014-2534-4 · Cited by 30 · see citing works
Polytherapy in Bone Regeneration: Clinical Applications and Preliminary Considerations
Calori, G. M., Colombo, M., Ripamonti, C. I., Bucci, M. S., Fadigati, P., Mazza, E. L., Mulas, S. G., & Tagliabue, L. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320110241s216 · Cited by 30 · see citing works
Self-citationBarcak, E., & Beebe, M. J. (2017) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2017.03.004 · Cited by 30 · see citing works
Kolk, A., Tischer, T., Koch, C., Vogt, S., Haller, B., Smeets, R., Kreutzer, K., Plank, C., & Bissinger, O. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35773 · Cited by 28 · see citing works
Regenerative Medicine: A New Paradigm in Bone Regeneration
Chaparro, O., & Linero, I. (2016) · InTech eBooks · doi:10.5772/62523 · Cited by 28 · see citing works
A synthetic BMP-2 mimicking peptide induces glioblastoma stem cell differentiation
Rampazzo, E., Dettin, M., Maule, F., Scabello, A., Calvanese, L., D’Auria, G., Falcigno, L., Porcù, E., Zamuner, A., Puppa, A. D., et al. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.07.001 · Cited by 28 · see citing works
Treatment of long bone nonunions: factors affecting healing.
Egol, K. A., Bechtel, C. P., Spitzer, A. B., Rybak, L., Walsh, M., & Davidovitch, R. I. (2012) · PubMed · Cited by 28 · see citing works
Tissue Engineered Strategies for Pseudoarthrosis
Longo, U. G., Trovato, U., Loppini, M., Rizzello, G., Khan, W. S., Maffulli, N., & Denaro, V. (2012) · The Open Orthopaedics Journal · doi:10.2174/1874325001206010564 · Cited by 27 · see citing works
Calori, G. M., Capanna, R., Colombo, M., Biase, P. D., O'Sullivan, C., Cartareggia, V., & Conti, C. (2013) · Injury · doi:10.1016/j.injury.2013.08.012 · Cited by 27 · see citing works
Self-citationMarongiu, G., Contini, A., Lepri, A. C., Donadu, M. G., Verona, M., & Capone, A. (2020) · Bioengineering · doi:10.3390/bioengineering7010022 · Cited by 25 · see citing works
Lu, Y., & Lekszycki, T. (2016) · Mathematics and Mechanics of Solids · doi:10.1177/1081286516653272 · Cited by 24 · see citing works
BMPs: Options, Indications, and Effectiveness
Giannoudis, P. V., & Dinopoulos, H. (2010) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0b013e3181cde5be · Cited by 24 · see citing works
Self-citationManagement and outcome of diaphyseal aseptic non-unions of the lower limb: A systematic review
Pneumaticos, S. G., Panteli, M., Triantafyllopoulos, G. K., Papakostidis, C., & Giannoudis, P. V. (2013) · The Surgeon · doi:10.1016/j.surge.2013.10.007 · Cited by 24 · see citing works
Self-citationCaterini, R., Potenza, V., Ippolito, E., & Farsetti, P. (2016) · Injury · doi:10.1016/j.injury.2016.07.044 · Cited by 24 · see citing works
Kaspiris, A., Hadjimichael, A. C., Vasiliadis, E. S., Papachristou, D. J., Giannoudis, P. V., & Panagiotopoulos, E. C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133901 · Cited by 23 · see citing works
Self-citationFracture healing and bone regeneration: Autologous bone grafting or BMPs?
Giannoudis, P. V. (2009) · Injury · doi:10.1016/j.injury.2009.10.004 · Cited by 23 · see citing works
Self-citationAutologous Bone Graft: When Shall We Add Growth Factors?
Giannoudis, P. V., & Dinopoulos, H. (2009) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2009.07.004 · Cited by 22 · see citing works
Self-citationMishra, R., Sefcik, R. S., Bishop, T. J., Montelone, S. M., Crouser, N. J., Welter, J. F., Caplan, A. I., & Dean, D. (2016) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2016.0094 · Cited by 22 · see citing works
Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7
Papanagiotou, M., Dailiana, Z. H., Karachalios, T., Varitimidis, S. E., Hantes, M. E., Dimakopoulos, G., Vlychou, M., & Malizos, Κ. Ν. (2017) · World Journal of Orthopedics · doi:10.5312/wjo.v8.i1.36 · Cited by 21 · see citing works
Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma
Mittwede, P. N., Gottardi, R., Alexander, P. G., Tarkin, I. S., & Tuan, R. S. (2018) · Current Pathobiology Reports · doi:10.1007/s40139-018-0166-x · Cited by 20 · see citing works
Treatment of long bone aseptic non-unions: Monotherapy or polytherapy?
Giannoudis, P. V., & Kontakis, G. M. (2009) · Injury · doi:10.1016/j.injury.2009.07.064 · Cited by 20 · see citing works
Self-citationWu, Z. X., Liu, D., Wan, S. Y., Zhang, Y., Lei, W., & Cui, G. (2011) · Journal of Orthopaedic Science · doi:10.1007/s00776-010-0019-x · Cited by 19 · see citing works
Management of tibial non-unions according to a novel treatment algorithm
Ferreira, N., & Marais, L. C. (2015) · Injury · doi:10.1016/j.injury.2015.09.040 · Cited by 19 · see citing works
Shin, J. A., Kang, J. L., Lee, K.-E., & Park, E. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9806-6 · Cited by 19 · see citing works
Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19 · see citing works
Gavénis, K., Heussen, N. M., Hofman, M., Andereya, S., Schneider, U., & Schmidt-Rohlfing, B. (2013) · Journal of Biomaterials Applications · doi:10.1177/0885328213491440 · Cited by 17 · see citing works
Mechanobiology in the management of mobile atrophic and oligotrophic tibial nonunions
Ferreira, N., Marais, L. C., & Aldous, C. M. (2015) · Journal of Orthopaedics · doi:10.1016/j.jor.2015.10.012 · Cited by 16 · see citing works
Neoplasia following use of BMPs: is there an increased risk?
Pountos, I., Panteli, M., Georgouli, T., & Giannoudis, P. V. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.968124 · Cited by 16 · see citing works
Self-citationAutologous Bone Graft: When Shall We Add Growth Factors?
Giannoudis, P. V., & Dinopoulos, H. (2010) · Foot and Ankle Clinics · doi:10.1016/j.fcl.2010.09.005 · Cited by 15 · see citing works
Self-citationKostić, I., Mitković, M., & Mitković, M. (2017) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2017.08.006 · Cited by 15 · see citing works
Bone Grafts and Bone Substitutes for Bone Defect Management
Wang, W., & Yeung, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-73664-8_18 · Cited by 14 · see citing works
Fracture Healing: Back to Basics and Latest Advances
Pountos, I., & Giannoudis, P. V. (2018) · Springer eBooks · doi:10.1007/978-3-319-68628-8_1 · Cited by 13 · see citing works
Self-citationRodham, P. L., & Giannoudis, P. V. (2022) · Injury · doi:10.1016/j.injury.2022.09.002 · Cited by 12 · see citing works
Self-citationSenta, H., Bergeron, E., Drevelle, O., Park, H., & Faucheux, N. (2011) · The Canadian Journal of Chemical Engineering · doi:10.1002/cjce.20453 · Cited by 12 · see citing works
Biomimetic materials for controlling bone cell responses
Drevelle, O. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s378 · Cited by 12 · see citing works
Merrick, M. T., Hamilton, K. D., & Russo, S. S. (2013) · The Spine Journal · doi:10.1016/j.spinee.2013.05.024 · Cited by 12 · see citing works
Bone Healing: The Diamond Concept
Giannoudis, P. V., Panteli, M., & Calori, G. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-54030-1_1 · Cited by 11 · see citing works
Self-citationStrategies for in situ tissue engineering of vascularized bone regeneration (Review)
He, Y., Liang, L., Luo, C., Zhang, Z., & Huang, J. (2023) · Biomedical Reports · doi:10.3892/br.2023.1625 · Cited by 10 · see citing works
- Authors
- Kanakaris, N. K., Calori, G. M., Verdonk, R., Burssens, P., Biase, P. D., Capanna, R., Vangosa, L. B., Cherubino, P., Baldo, F., Ristiniemi, J., Kontakis, G., & Giannoudis, P. V.
- Affiliations
- University of Leeds (GB)
- University of Milan (IT)
- Ghent University Hospital (BE)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Oulu University Hospital (FI)
- Corresponding author
- Giannoudis, Peter V.
- ORCID
- Venue
- Injury
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 39
- Pages
- S83-S90
- ISSN
- 0020-1383 (ISSN-L)
- OpenAlex
- W2171495416
- Cited by
- 150
- References
- 65
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 12 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 18 · 2012: 15
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Injury (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- BMP-7, OP-1, bone morphogenetic proteins, tibial nonunion, nonunion, revision fixation, treatment efficacy and safety
- MeSH terms
- Adult, Aged, Female, Fracture Fixation, Fractures, Ununited, Humans, Male, Middle Aged, Prospective Studies, Radiography, Reoperation, Tibial Fractures, Transplantation, Autologous, Treatment Outcome, Fracture Healing, Bone Morphogenetic Protein 7
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
