Bone mechanical properties and changes with osteoporosis

Osterhoff, Georg; Morgan, Elise F.; Shefelbine, Sandra J.; Karim, Lamya; McNamara, Laoise M.; Augat, Peter

doi:10.1016/s0020-1383(16)47003-8

Cited by 557Bone health and osteoporosis researchBone Metabolism and DiseasesBone fractures and treatments

Bone mechanical properties and changes with osteoporosis

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Osterhoff, Georg, Morgan, Elise F., Shefelbine, Sandra J., Karim, Lamya, McNamara, Laoise M., Augat, Peter·2016·Injury

DOI 10.1016/s0020-1383(16)47003-8PMC PMC4955555

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Abstract

This review will define the role of collagen and within-bone heterogeneity and elaborate the importance of trabecular and cortical architecture with regard to their effect on the mechanical strength of bone. For each of these factors, the changes seen with osteoporosis and ageing will be described and how they can compromise strength and eventually lead to bone fragility.

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Areal bone mineral density (BMD) is a measurable, critical component of bone strength.
“A measurable, critical component for the bone strength is the areal bone mineral density (BMD) [1].”
From A human mission to Mars: Predicting the bone mineral density loss of astronauts (2020) · cites this paper as [1]

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Current Status of the Diagnosis and Management of Osteoporosis
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“A measurable, critical component for the bone strength is the areal bone mineral density (BMD) [1].”
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Osteocyte Wnt/β-catenin pathway activation upon mechanical loading is altered in ovariectomized mice
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Authors: Osterhoff, G., Morgan, E. F., Shefelbine, S. J., Karim, L., McNamara, L. M., & Augat, P.
Affiliations: University of British Columbia (CA)
Boston University (US)
Northeastern University (US)
Beth Israel Deaconess Medical Center (US)
National University of Ireland (IE)
Paracelsus Medical University (AT)
Corresponding author: Augat, Peter
ORCID: Osterhoff, Georg
Morgan, Elise F.
Shefelbine, Sandra J.
Karim, Lamya
McNamara, Laoise M.
Augat, Peter
Venue: Injury
Publisher: Elsevier BV
Published: 2016-06
Volume: 47
Pages: S11-S20
ISSN: 0020-1383 (ISSN-L)
DOI: 10.1016/s0020-1383(16)47003-8
PMC: PMC4955555
OpenAlex: W2474969214
Cited by: 557
References: 114
Citations by year: 2026: 64 · 2025: 57 · 2024: 77 · 2023: 70 · 2022: 77 · 2021: 72 · 2020: 64 · 2019: 52 · 2018: 16 · 2017: 6 · 2016: 1
FWCI: 3.99
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Injury (publishedVersion)
PubMed (publishedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Research Repository UCD (University College Dublin) (cc-by-nc)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054620)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Keywords: bone mechanical properties, osteoporosis, collagen, trabecular bone microarchitecture, bone strength, bone fragility, aging, fragility fractures
MeSH terms: Aging, Biomechanical Phenomena, Collagen, Humans, Osteocytes, Osteoporosis, Bone Density, Weight-Bearing, Bone Remodeling

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Bone mechanical properties and changes with osteoporosis

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