Enhancement of preheparin serum lipoprotein lipase mass by bezafbirate administration
Abstract
To clarify the clinical implication of preheparin serum lipoprotein lipase mass (preheparin LpL mass), we studied the relationships between preheparin LpL mass and serum lipids, including midband lipoproteins, which migrate between very low density lipoproteins and low density lipoproteins on polyacrylamide gel disc electrophoresis, in hyperlipidemias. And we also studied the changes of preheparin LpL mass in hypertriglyceridemic patients during bezafibrate administration, which is known to enhance LpL activity in postheparin plasma. Preheparin LpL mass correlated positively with high-density lipoprotein-cholesterol (HDL-C) (r=0.418, P<0.01) and negatively with triglyceride (TG) (r=-0.256, P<0.01), but did not correlate with total cholesterol (TC) in 64 hyperlipidemic (type IIa, IIb and IV) patients. The midband lipoproteins were observed in 80% of hypertriglyceridemic patients (32/40). Preheparin LpL mass in midband lipoprotein-positive subjects was lower significantly than that in midband-negative subjects. When bezafibrate (400 mg/day) was administrated to 40 hypertriglyceridemic patients for 4 months, TG level significantly decreased (-49+/-7%, P<0.01), TC levels decreased (-11+/-4%, not significant), and HDL-C levels increased (+27+/-4%, P<0.01). The midband lipoproteins disappeared in 95% of patients. Preheparin LpL mass significantly increased (+25+/-6%, P<0. 0005). In nine patients who stopped bezafibrate, TG levels significantly increased (+49+/-7%, P<0.01) and HDL-C levels decreased (-27+/-4%, P<0.01). Preheparin LPL mass significantly decreased (-25+/-6%, P<0.0005). These results suggested that bezafibrate administration enhanced preheparin LpL mass. And it might be implicated that enhanced LpL production by bezafibrate could reflect an increase of preheparin LpL mass.
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12 weeks of jogging training increased pre-heparin LPL concentrations in overweight men.
“However, with several findings showing that pre-heparin LPL concentration indicate the amount of systemic LPL activity [64–66], Tanaka et al. turned the target to pre-heparin LPL, and found that 12 weeks of jogging training increased pre-heparin LPL concentrations in overweight men [67].”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [67]
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- Authors
- Totsuka, M., Miyashita, Y., Ito, Y., Watanabe, H., Murano, T., & Shirai, K.
- Affiliations
- Toho University (JP)
- Corresponding author
- Shirai, Kohji
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 153
- Issue
- 1
- Pages
- 175-179
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2094303805
- Cited by
- 43
- References
- 23
- Citations by year
- 2025: 3 · 2021: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 4
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kissei
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipoprotein lipase, bezafibrate, hypertriglyceridemia, hyperlipidemia, HDL cholesterol, triglycerides, lipoprotein lipase activity, type II hyperlipoproteinemia, type IV hyperlipoproteinemia, drug withdrawal effects, serum lipids
- MeSH terms
- Hypolipidemic Agents, Bezafibrate, Drug Administration Schedule, Enzyme-Linked Immunosorbent Assay, Humans, Hyperlipidemias, Lipids, Lipoprotein Lipase, Lipoproteins, Electrophoresis, Gel, Two-Dimensional, Hypertriglyceridemia
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