Twelve-Week Jogging Training Increases Pre-Heparin Serum Lipoprotein Lipase Concentrations in Overweight/Obese Middle-Aged Men
Open accessAbstract
AIM: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men. METHODS: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL. RESULTS: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean+/-SEM: 37.6+/-4.7 vs. 51.0+/-6.6 ng/mL, respectively, p= 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks. CONCLUSIONS: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men.
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Exercise-induced LPL changes are time-delayed; LPL mRNA peak level occurs at 4 h after exercise.
“Exercise-induced LPL changes were time-delayed, for example, LPL mRNA peak level occurred at 4 h after exercise [62].”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [62]
Most catalytically active LPL is located in the vessel wall and is released into the blood after intravenous injection of heparin.
“Most of the catalytically active LPL is located in the vessel wall and then isolated from the endothelium surface and released in the blood after intravenous injection of heparin [62].”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [62]
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Duncan, G. E., Perri, M. G., Theriaque, D. W., Hutson, A. D., Eckel, R. H., & Stacpoole, P. W. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.557 · Cited by 425 · see citing works
Effect of Intensity of Aerobic Training on V˙O2max
GORMLEY, S. E., SWAIN, D. P., HIGH, R., SPINA, R. J., DOWLING, E. A., KOTIPALLI, U. S., & GANDRAKOTA, R. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816c4839 · Cited by 307 · see citing works
Metabolic Regulation: A Human Perspective
Frayn, K. N. (1996) · Cited by 276 · see citing works
Effects of four different single exercise sessions on lipids, lipoproteins, and lipoprotein lipase
Ferguson, M. A., Alderson, N. L., Trost, S. G., Essig, D. A., Burke, J. R., & Durstine, J. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.1169 · Cited by 245 · see citing works
Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue
Seip, R. L., Angelopoulos, T. J., & Semenkovich, C. F. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.2.e229 · Cited by 190 · see citing works
Seip, R. L., Mair, K., Cole, T. G., & Semenkovich, C. F. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.2.e255 · Cited by 173 · see citing works
Moderate exercise, postprandial lipemia, and skeletal muscle lipoprotein lipase activity
Herd, S. L., Kiens, B., Boobis, L., & Hardman, A. E. (2001) · Metabolism · doi:10.1053/meta.2001.24199 · Cited by 152 · see citing works
Physical Activity and High Density Lipoprotein Cholesterol Levels
Kokkinos, P. F., & Fernhall, B. (1999) · Sports Medicine · doi:10.2165/00007256-199928050-00002 · Cited by 146 · see citing works
Taskinen, M., & Nikkil�, E. A. (1979) · Diabetologia · doi:10.1007/bf01236268 · Cited by 145 · see citing works
Seip, R. L., & Semenkovich, C. F. (1998) · PubMed · Cited by 137 · see citing works
Gill, J. M. R., Frayn, K. N., Wootton, S. A., Miller, G. J., & Hardman, A. E. (2001) · Clinical Science · doi:10.1042/cs1000517 · Cited by 109 · see citing works
The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining.
Simsolo, R. B., Ong, J. M., & Kern, P. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116813 · Cited by 109 · see citing works
Preheparin serum lipoprotein lipase mass might be a biomarker of metabolic syndrome
Saiki, A., Oyama, T., Endo, K., Ebisuno, M., Ohira, M., Koide, N., Murano, T., Miyashita, Y., & Shirai, K. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.08.004 · Cited by 82 · see citing works
Taskinen, M., & Nikkilä, E. A. (1980) · PubMed · Cited by 75 · see citing works
Gill, J. M. R., Herd, S. L., Vora, V., & Hardman, A. E. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0788-9 · Cited by 70 · see citing works
Valle, A. M., O’Connor, D. T., Taylor, P., Zhu, G., Montgomery, G. W., Slagboom, P. E., Martin, N. G., & Whitfield, J. B. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.065052 · Cited by 70 · see citing works
Watanabe, H., Miyashita, Y., Murano, T., Hiroh, Y., Itoh, Y., & Shirai, K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00012-x · Cited by 69 · see citing works
The effect of insulin sensitizer, troglitazone, on lipoprotein lipase mass in preheparin serum
Shirai, K., Itoh, Y., Sasaki, H., Totsuka, M., Murano, T., Watanabe, H., & Miyashita, Y. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00063-7 · Cited by 64 · see citing works
Miyashita, Y., Shirai, K., Itoh, Y., Sasaki, H., Totsuka, M., Murano, T., & Watanabe, H. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00369-2 · Cited by 62 · see citing works
Enhancement of preheparin serum lipoprotein lipase mass by bezafbirate administration
Totsuka, M., Miyashita, Y., Ito, Y., Watanabe, H., Murano, T., & Shirai, K. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)00394-4 · Cited by 43 · see citing works
Significance of skeletal muscle properties on fitness, long-term physical training and serum lipids
Tikkanen, H. O., Hämäläinen, E. K., & Härkönen, M. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00261-5 · Cited by 37 · see citing works
Oyama, T., Saiki, A., Endoh, K., Ban, N., Nagayama, D., Ohira, M., Koide, N., Miyashita, Y., & Shirai, K. (2008) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e549 · Cited by 35 · see citing works
Serum lipoprotein lipase mass: Clinical significance of its measurement
Kobayashi, J., Nohara, A., Kawashiri, M.-A., Inazu, A., Koizumi, J., Nakajima, K., & Mabuchi, H. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.12.003 · Cited by 35 · see citing works
Hirano, T., Nishioka, F., & Murakami, T. (2004) · Metabolism · doi:10.1016/j.metabol.2003.10.021 · Cited by 34 · see citing works
8 Skeletal Muscle Lipoprotein Lipase
Seip, R. L., & SEAMENKOVICH, C. F. (1998) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199800260-00010 · Cited by 31 · see citing works
Nomata, Y., Kume, N., Sasai, H., Katayama, Y., Nakata, Y., Okura, T., & Tanaka, K. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.018 · Cited by 26 · see citing works
Self-citationMiyashita, M., & Tokuyama, K. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853438 · Cited by 23 · see citing works
Self-citationMiyashita, Y., & Shirai, K. (2005) · Current Medicinal Chemistry - Cardiovascular & Hematological Agents · doi:10.2174/156801605774322292 · Cited by 21 · see citing works
Pre-heparin Lipoprotein Lipase Mass
Kobayashi, J. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.1 · Cited by 17 · see citing works
Obesity phenotype and intra-abdominal fat responses to regular aerobic exercise
Sasai, H., Katayama, Y., Nakata, Y., Ohkubo, H., & Tanaka, K. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.03.011 · Cited by 16 · see citing works
Self-citationHitsumoto, T., Takahashi, M., Iizuka, T., & Shirai, K. (2008) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e547 · Cited by 10 · see citing works
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Research works printed but not linked: 1
- Gormley SE, Swain DP, High R, Spina RJ, Dowling EA, Kotipalli US, Gandrakota R: Effect of intensity of aerobic training on VO2max. Med Sci Sports Exerc, 2008; 40: 1336-1343
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Wang, Y., & Xu, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0515-5 · Cited by 436 · see citing works
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Olivecrona, G., & Olivecrona, T. (1995) · Current Opinion in Lipidology · doi:10.1097/00041433-199510000-00009 · Cited by 238 · see citing works
Donnelly, J. E., Herrmann, S. D., Lambourne, K., Szabo‐Reed, A. N., Honas, J. J., & Washburn, R. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083498 · Cited by 132 · see citing works
Lee, K., Tripathy, D., Demark‐Wahnefried, W., Courneya, K. S., Sami, N., Bernstein, L., SPICER, D. V., Buchanan, T. A., Mortimer, J. E., & Dieli-Conwright, C. M. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.0038 · Cited by 76 · see citing works
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Chen, T. C., Hsieh, C.-C., Tseng, K., Ho, C., & Nosaka, K. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001267 · Cited by 72 · see citing works
Triglyceride lipases and atherosclerosis
Olivecrona, G., & Olivecrona, T. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833ded83 · Cited by 62 · see citing works
Teeman, C. S., Kurti, S. P., Cull, B. J., Emerson, S. R., Haub, M. D., & Rosenkranz, S. K. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0142-6 · Cited by 59 · see citing works
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Bhatnagar, R., Dixit, N. M., Yang, E. H., & Sallam, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.925816 · Cited by 47 · see citing works
Oh, S., Tanaka, K., Tsujimoto, T., So, R., Shida, T., & Shoda, J. (2014) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2013.0143 · Cited by 43 · see citing works
Self-citationAhmad, T., Chasman, D. I., Buring, J. E., Lee, I.-M. M., Ridker, P. M., & Everett, B. M. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.957290 · Cited by 39 · see citing works
Costa, R. R., Pilla, C., Buttelli, A. C. K., Barreto, M. F., Vieiro, P. A., Alberton, C. L., Bracht, C. G., & Kruel, L. F. M. (2018) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2018.1441485 · Cited by 25 · see citing works
Rodríguez-Mortera, R., Caccavello, R. J., Garay‐Sevilla, M. E., & Gugliucci, A. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.014 · Cited by 21 · see citing works
Matsumoto, R., Tsunekawa, K., Shoho, Y., Yanagawa, Y., Kotajima, N., Matsumoto, S., Araki, O., Kimura, T., Nakajima, K., & Murakami, M. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1014-7 · Cited by 20 · see citing works
Lin, W. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00436-2 · Cited by 15 · see citing works
Takahashi, M., Miyashita, M., Park, J., Kawanishi, N., Bae, S.-R., NAKAMURA, Y., Sakamoto, S., & Suzuki, K. (2013) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.59.375 · Cited by 14 · see citing works
Self-citationCosta, R. R., Buttelli, A. C. K., Fagundes, A. D. O., Fonseca, G. A., Pilla, C., Barreto, M. F., Viero, P. A., da Rocha, V. D. M. B., Alberton, C. L., & Kruel, L. F. M. (2020) · Clinics · doi:10.6061/clinics/2020/e1183 · Cited by 10 · see citing works
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Oh, S., Tanaka, K., Noh, J., So, R., Tsujimoto, T., Sasai, H., Kim, M., & Shoda, J. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s64546 · Cited by 9 · see citing works
Self-citationAruga, M., Tokita, Y., Nakajima, K., Kamachi, K., & Tanaka, A. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.10.017 · Cited by 8 · see citing works
Yamasaki, M., Mutombo, P. B. W. B., Iwamoto, M., Nogi, A., Hashimoto, M., Nabika, T., & Shiwaku, K. (2015) · Nutrition Research and Practice · doi:10.4162/nrp.2015.9.4.379 · Cited by 5 · see citing works
Guo, Y.-H., Wang, F., Hu, J., Wang, Y., & Zhang, L. (2014) · PubMed Central · Cited by 5 · see citing works
Miyashita, M., Eto, M., Sasai, H., Tsujimoto, T., So, R., Nomata, Y., & Tanaka, K. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5173 · Cited by 2 · see citing works
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Harun, I. (2021) · Amerta Nutrition · doi:10.20473/amnt.v5i1.2021.91-97 · Cited by 2 · see citing works
Torkamaneh, S., Gené‐Morales, J., Juesas, Á., Flández, J., Hammami, R., Rafieian-Kopaei, M., & Colado, J. C. (2021) · Autumn Conferences of Sports Science · doi:10.14198/jhse.2021.16.proc2.47 · Cited by 1 · see citing works
Costa, R. R. (2011) · Americanae (AECID Library) · doi:10.13140/rg.2.2.26954.16328 · Cited by 1 · see citing works
Teeman, C. S., Kurti, S. P., Cull, B. J., Emerson, S. R., Haub, M. D., & Rosenkranz, S. K. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.1163.2
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- Authors
- Miyashita, M., Eto, M., Sasai, H., Tsujimoto, T., Nomata, Y., & Tanaka, K.
- Affiliations
- University of Tsukuba (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2010
- Volume
- 17
- Issue
- 1
- Pages
- 21-29
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W1972547214
- Cited by
- 28
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare
- Meiji Yasuda Life Foundation of Health and Welfare
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein lipase, jogging, aerobic exercise training, overweight, obesity, middle-aged men, brisk walking, exercise training response
- MeSH terms
- Adult, Anticoagulants, Heparin, Humans, Jogging, Lipoprotein Lipase, Male, Middle Aged, Obesity, Oxygen Consumption, Triglycerides, Exercise, Diet Records, Walking, Overweight, Lipid Metabolism
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