Preheparin serum lipoprotein lipase mass level: the effects of age, gender, and types of hyperlipidemias
Abstract
To clarify the factors regulating preheparin serum lipoprotein lipase mass (preheparin LPL mass), the correlations between preheparin LPL mass and age, gender and types of hyperlipidemias were investigated in 377 persons who underwent annual health examinations. Preheparin LPL mass level did not significantly differ in individuals from 19 to 70 years old, for both men and women. Preheparin LPL mass level correlated negatively with triglyceride (TG), positively with high density lipoprotein-cholesterol (HDL-C), and not at all with total cholesterol (TC) or low density lipoprotein-cholesterol (LDL-C). Preheparin LPL mass levels were apparently higher in women than in men, but when serum lipid levels were adjusted, preheparin LPL mass levels were identical. In type IV and IIb hyperlipidemia, preheparin LPL mass levels were lower than in type IIa patients and in normals. Remnant positive individuals had lower levels of preheparin LPL mass than the negative individuals. In conclusion, preheparin LPL mass levels were not affected by aging and gender, but were lower in the conditions in which TG catabolism was disturbed, indicating that preheparin LPL mass might reflect somewhat the amount of LPL working in the body.
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Pre-heparin LPL concentration indicates the amount of systemic LPL activity.
“However, with several findings showing that pre-heparin LPL concentration indicate the amount of systemic LPL activity [64–66], Tanaka et al. turned the target to pre-heparin LPL, and found that 12 weeks of jogging training increased pre-heparin LPL concentrations in overweight men [67].”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [66]
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Self-citation
- Authors
- Watanabe, H., Miyashita, Y., Murano, T., Hiroh, Y., Itoh, Y., & Shirai, K.
- Affiliations
- Toho University (JP)
- Corresponding author
- Shirai, Kohji
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 145
- Issue
- 1
- Pages
- 45-50
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2107020693
- Cited by
- 69
- References
- 24
- Citations by year
- 2025: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- lipoprotein lipase, hyperlipidemia, triglyceride catabolism, HDL cholesterol, age and sex differences, remnant lipoproteins, type IV hyperlipidemia, type II hyperlipidemia, lipoprotein lipase activity
- MeSH terms
- Adult, Age Factors, Aged, Cholesterol, Female, Heparin, Humans, Hyperlipidemias, Lipoprotein Lipase, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Sex Factors, Triglycerides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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