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Cited by 20Thermoregulation and physiological responsesCardiovascular and exercise physiologyBlood properties and coagulation

Increased cutaneous blood flow but impaired post-ischemic response of nutritional flow in obese children

Chin, Lien-Chun, Huang, Teh-Yang, Yu, Chia-Li, Wu, Chi-Hong, Hsu, Chin-Che, Yu, Hsin-Su·1999·Atherosclerosis
DOI 10.1016/s0021-9150(99)00135-5
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Abstract

It is well known that cardiovascular risk factors and dyslipidemia along with obesity can be identified early in life. Serum lipids and lipoproteins influence skin vessel reactivity in adults. The purpose of this study was to investigate the cutaneous microcirculation and its correlation to dyslipidemia in obese children. Thirty-four obese children and an equal number of age- and sex-matched healthy children were enrolled in this study. Laser Doppler flowmetry and dynamic capillaroscopy were performed to measure total cutaneous blood flow and nutritional blood flow, respectively. A significantly higher cutaneous baseline flow and peak flow after a 1-min arterial occlusion was noticed in obese group as compared to normal control. Results of dynamic capillaroscopy revealed values of resting capillary blood cell velocity that did not differ from controls but a significantly lower peak CBV after a 1-min arterial occlusion in obesity. Plasma lipids examination showed a high triglycerides and low high density lipoprotein cholesterol levels in obesity. Pearson analysis detected no significant correlations between pCBV, baseline flow and peak flow and dyslipidemia in obesity. These results may be explained by the fact that the duration of dyslipidemia in our study population was not long enough to cause vascular damage or the dyslipidemia was not pronounced enough to have an impact on skin vessel activity tests. It is also possible, that the combination of methods used in the present study was not sensitive enough to detect an existing correlations between flow values and high triglycerides/low HDL-cholesterol values in the obese group. Our results suggest that all the responses of the cutaneous microcirculation were mainly due to physiological compensatory rather than pathological reactions in young obese children. The results of cutaneous microcirculatory assessment in obese children provide follow-up parameters for assessing the risk of cardiovascular diseases later in life.

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  • Individuals with obesity experience increased cutaneous blood flow to meet the oxygenation needs of tissue, but the blood flow of adipose tissue generally decreases with obesity both after a meal and during a fasting state.

    “Individuals with obesity experience increased cutaneous blood flow to meet the oxygenation needs of tissue. However, the blood flow of adipose tissue generally decreases with obesity both after a meal and during a fasting state [61,72].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [61]

  • Publications that experimentally and explicitly demonstrate the effect of obesity or BMI on the PPG waveform are limited.

    “While, to the authors’ knowledge, publications that experimentally and explicitly demonstrate the effect of obesity or BMI on the PPG waveform are limited, we will explore works which suggest that there would be a substantial effect [56,59,60,61,62,63,64,65,66,67,68,69,70].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [61]

  • The effect of obesity on dermal capillary density could lead to a decrease in the dominant 'DC' component of a PPG waveform due to the increased blood volume of the obese.

    “This effect of obesity could lead to a decrease in the dominant “DC” component of a PPG waveform due to the increased blood volume of the obese [61,62,63,64].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [61]

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Authors
Chin, L.-C., Huang, T.-Y., Yu, C.-L., Wu, C.-H., Hsu, C.-C., & Yu, H.-S.
Affiliations
  • Kaohsiung Medical University (TW)
  • National Taiwan University (TW)
Corresponding author
Yu, Hsin-Su
ORCID
Yu, Chia-Li
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1999-09
Volume
146
Issue
1
Pages
179-185
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(99)00135-5
OpenAlex
W2031693481
Cited by
20
References
39
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
Keywords
childhood obesity, skin microcirculation, skin blood flow, dyslipidemia, triglycerides, HDL cholesterol, arterial occlusion, cardiovascular risk, compensatory vasodilation
MeSH terms
Adolescent, Capillaries, Child, Child, Preschool, Cholesterol, Female, Humans, Hyperlipidemias, Ischemia, Male, Microcirculation, Nutritional Status, Obesity, Reference Values, Regional Blood Flow, Skin, Ultrasonography, Laser-Doppler Flowmetry

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