Cited by 338Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

Open access
Sausville, E, Carney, D, Battey, J·1985·Journal of Biological Chemistry

Abstract

The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

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Crossref · 10.1016/s0021-9258(17)39236-0

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  • OXT encodes the oxytocin prepropeptide containing the nonapeptide oxytocin and the carrier protein neurophysin-I.

    “oxytocin-neurophysin I (OXT) encodes the oxytocin prepropeptide containing the nonapeptide oxytocin and the carrier protein neurophysin-I16.”

    From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [16]

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Authors
Sausville, E., Carney, D., & Battey, J.
Affiliations
Walter Reed National Military Medical Center (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1985-08
Volume
260
Issue
18
Pages
10236-10241
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2102290655
Cited by
338
References
18
Citations by year
2026: 1 · 2025: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 7
FWCI
24.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords
vasopressin gene, oxytocin gene, genetic linkage, neurophysin II, neurophysin I, small cell lung cancer, gene expression, exon-intron structure, gene cloning, mRNA synthesis
MeSH terms
Amino Acid Sequence, Arginine Vasopressin, Base Sequence, Cell Line, Cloning, Molecular, DNA Restriction Enzymes, Genes, Genetic Vectors, Humans, Genetic Linkage, Lung Neoplasms, Neurophysins, Oxytocin, Protein Precursors, Vasopressins

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