The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Primary structure of human pepsinogen gene.
Open accessAbstract
A recombinant clone, which covers the pepsinogen gene in a single insert, has been isolated by screening a library of human genomic DNA, using a swine pepsinogen cDNA as a probe. Sequence analysis of coding DNA segments of the clone revealed that the pepsinogen gene occupies approximately 9.4-kilobase pairs of the genomic DNA and is separated into nine exons by eight introns of various lengths. The predicted amino acid sequence of human pepsinogen consists of 373 residues and is 82% homologous with that of swine pepsinogen. In addition, the predicted sequence contained a single sequence of 15 amino acid residues at the NH2 terminus, showing that the protein is synthesized as prepepsinogen. The structure of the gene, in which two homologous sequences including the two active site aspartyl residues of pepsin are present in different coding segments, is in support of the view that the pepsinogen gene evolved by duplication of a shorter ancestral gene.
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Cites
Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
Cited by
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
Kozak, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.2.857 · Cited by 3,293
Woolford, C. A., Daniels, L. B., Park, F. J., Jones, E. W., Van Arsdell, J. N., & Innis, M. A. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.7.2500 · Cited by 302
Evolution in the structure and function of aspartic proteases
Tang, J., & Wong, R. N. S. (1987) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240330106 · Cited by 302
Cloning and sequence analysis of cDNA for human renin precursor.
Imai, T., Miyazaki, H., Hirose, S., Hori, H., Hayashi, T., Kageyama, R., Ohkubo, H., Nakanishi, S., & Murakami, K. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7405 · Cited by 271
Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development
Kageyama, T. (2002) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-002-8423-9 · Cited by 256
Metadata
- Authors
- Sogawa, K., Fujii-Kuriyama, Y., Mizukami, Y., Ichihara, Y., & Takahashi, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-04
- Volume
- 258
- Issue
- 8
- Pages
- 5306-5311
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1575543696
- Cited by
- 205
- References
- 2
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sogawa, K., Fujii-Kuriyama, Y., Mizukami, Y., Ichihara, Y., & Takahashi, K. (1983). Primary structure of human pepsinogen gene. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)32572-9
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