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The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
Open accessAbstract
The cytotoxic effects of many quinones are thought to be mediated through their one-electron reduction to semiquinone radicals, which subsequently enter redox cycles with molecular oxygen to produce active oxygen species and oxidative stress. The two-electron reduction of quinones to diols, mediated by DT-diaphorase (NAD(P)H: (quinone-acceptor) oxidoreductase), may therefore represent a detoxifying pathway which protects the cell from the formation of these reactive intermediates. By using menadione (2-methyl-1,4-naphthoquinone) and isolated hepatocytes, the relative contribution of the two pathways to quinone metabolism has been studied and a protective role for DT-diaphorase demonstrated. Moreover, in the presence of cytotoxic concentrations of menadione rapid changes in intracellular thiol and Ca2+ homeostasis were observed. These were associated with alterations in the surface structure of the hepatocytes which may be an early indication of cytotoxicity.
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Metadata
- Authors
- Thor, H., Smith, M. T., Hartzell, P., Bellomo, G., Jewell, S. A., & Orrenius, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-10
- Volume
- 257
- Issue
- 20
- Pages
- 12419-12425
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1595656597
- Cited by
- 902
- References
- 0
- FWCI
- 43.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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