Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

Favreau, L V; Pickett, C B

doi:10.1016/s0021-9258(20)64358-7

Cited by 497Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor AgentsPharmacogenetics and Drug Metabolism

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

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Favreau, L V, Pickett, C B·1991·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(20)64358-7

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Abstract

We have identified two regions in the 5'-flanking sequence of the rat quinone reductase gene that contain xenobiotic responsive elements. The DNA sequence of the first region spans nucleotides -393 to -352 of the 5'-flanking region and shares sequence identity with the xenobiotic responsive element (XRE) described for the cytochrome P-450 CYPIA1 gene. The DNA sequence of the second region spans nucleotides -434 to -404 of the 5'-flanking region of the quinone reductase structural gene. When a synthetic oligonucleotide corresponding to nucleotides -434 to -404 was inserted in front of a heterologous promoter linked to the chloramphenicol acetyltransferase structural gene, an increase in basal level expression as well as responsiveness to beta-naphthoflavone and t-butylhydroquinone, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, was observed. The sequence, -434 to -404, did not have any sequence identity with the XRE but shared a large degree of identity with the antioxidant responsive element recently described for the rat glutathione S-transferase Ya subunit gene (Rushmore, T. H., King, R. G., Paulson, K. E., and Pickett, C. B. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3826-3830; Rushmore, T. H., and Pickett, C. B. (1990) J. Biol. Chem. 265, 14648-14653). These results indicate that the antioxidant responsive element can be distinguished functionally from the classical XRE and is also involved in the regulation of the quinone reductase gene by planar aromatic compounds and phenolic antioxidants.

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Type 1 HH is associated with several mutations of the HFE gene, which was originally identified during an analysis of 178 individuals with HH.
“Type 1 HH is associated with several mutations of the HFE gene, which was originally identified during an analysis of 178 individuals with HH (82).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [82]
Of 178 individuals with HH, 83% were homozygous for a missense mutation to a gene resembling MHC class I genes, located on chromosome 6.
“Of these, 83% were homozygous for a missense mutation to a gene resembling MHC class I genes, located on chromosome 6 (82).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [82]

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Authors: Favreau, L. V., & Pickett, C. B.
Affiliations: Merck Canada Inc. (Canada) (CA)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1991-03
Volume: 266
Issue: 7
Pages: 4556-4561
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(20)64358-7
OpenAlex: W1604748982
Cited by: 497
References: 36
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 6 · 2013: 16 · 2012: 13
FWCI: 8.59
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10793 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: NAD(P)H:quinone reductase, transcriptional regulation, 5'-flanking region, xenobiotic response element, antioxidant response element, beta-naphthoflavone, phenolic antioxidants, chloramphenicol acetyltransferase reporter, glutathione S-transferase Ya, rats
MeSH terms: Amino Acid Sequence, Animals, Antioxidants, Base Sequence, DNA Mutational Analysis, Enzyme Induction, Glutathione Transferase, Molecular Sequence Data, Oligonucleotides, Phenols, Promoter Regions, Genetic, Quinone Reductases, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Xenobiotics, Gene Expression Regulation, Enzymologic, NAD(P)H Dehydrogenase (Quinone), Rats

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Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

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