The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets.
Open accessAbstract
Proteins of the annexin/lipocortin family act as in vitro anticoagulants by binding to anionic phospholipid vesicles. In this study, we investigated whether annexin V (placental anticoagulant protein I) would bind to human platelets. Annexin V bound to unstimulated platelets in a reversible, calcium-dependent reaction with an apparent Kd of 7 nM and 5000-8000 sites/platelet. Additional binding sites could be induced by several platelet agonists in the following order of effectiveness: A23187 greater than collagen + thrombin greater than collagen greater than thrombin. However, neither ADP nor epinephrine induced additional binding sites. Three other proteins of the annexin family (annexins II, III, and IV) competed for annexin V platelets binding sites with the same relative potencies previously observed for binding to phospholipid vesicles. Phospholipid vesicles containing phosphatidylserine completely inhibited binding of annexin V to platelets. Annexin V completely blocked binding of 125I-factor Xa to thrombin-stimulated platelets. These results support the hypothesis that phosphatidylserine exposure occurs during platelet activation and may be necessary for assembly of the prothrombinase complex on platelet membranes.
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Cites
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Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.
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Changes in membrane phospholipid distribution during platelet activation
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COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES
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Self-citationMembrane asymmetry and blood coagulation
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Cited by
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Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
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Self-citationHeartache and heartbreak—the link between depression and cardiovascular disease
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Metadata
- Authors
- Thiagarajan, P., & Tait, J. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-10
- Volume
- 265
- Issue
- 29
- Pages
- 17420-17423
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1519535724
- Cited by
- 366
- References
- 27
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. https://app.cochat.ai/papers/10.1016/s0021-9258(18)38177-8
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- Thiagarajan, P., & Tait, J. F. (1990). Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)38177-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
