The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.
Open accessAbstract
Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on cotransfection of expression plasmids for the peroxisome proliferator-activated receptor, PPAR. Activation by PPAR is observed in the absence of the inducers. However, a mutant, PPAR-G (Glu282----Gly) activated luciferase expression only in the presence of peroxisome proliferators. Deletion analysis has localized a response element to a 34-base pair segment located 677 base pairs upstream of the CYP4A6 transcription start site that is similar to an element that regulates the response of the rat fatty acyl-CoA oxidase gene to peroxisome proliferators and that binds PPAR.
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Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish
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Metadata
- Authors
- Muerhoff, A. S., Griffin, K. J., & Johnson, E. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 267
- Issue
- 27
- Pages
- 19051-19053
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1542767024
- Cited by
- 311
- References
- 22
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. https://app.cochat.ai/papers/10.1016/s0021-9258(18)41738-3
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- Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992). The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)41738-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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