The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.
Open accessAbstract
Transforming growth factor-beta 1 (TGF-beta 1) has been found to occur as latent high molecular weight complexes, with or without an associated component denoted latent TGF-beta 1-binding protein (LTBP). We show here that a human glioblastoma cell line (U-1240 MG) secretes all isoforms of TGF-beta s found in mammalian cells (TGF-beta 1, -beta 2, and -beta 3). Approximately 26% of the secreted TGF-beta is in an active form. Latent TGF-beta s were partially purified from medium conditioned by the U-1240 MG cell line using anion exchange chromatography. Analysis of the different fractions by immunoblotting using antisera against precursor parts of the different TGF-beta isoforms, and against LTBP, revealed that not only TGF-beta 1 but also other isoforms of TGF-beta may occur in high molecular weight forms containing LTBP. In addition, each one of the TGF-beta isoforms occurred in smaller forms not containing LTBP. Interestingly, each of the TGF-beta isoforms was also seen in complexes of about 210 kDa containing associated component(s) distinct from LTBP. These results indicate that each of the different isoforms of TGF-beta is synthesized and secreted by this glioblastoma cell line in several different high molecular weight latent forms; the biological importance of the various latent TGF-beta complexes is discussed.
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Andres, J. L., Stanley, K., Cheifetz, S., & Massagué, J. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.6.3137 · Cited by 354
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Taipale, J., Miyazono, K., Heldin, C., & Keski-Oja, J. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.1.171 · Cited by 448
Self-citationTaipale, J., Lohi, J., Saarinen, J., Kovanen, P. T., & Keski-Oja, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4689 · Cited by 398
Microglia function in brain tumors
Watters, J. J., Schartner, J. M., & Badie, B. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20485 · Cited by 329
Schultz-Cherry, S., Ribeiro, S., Gentry, L., & Murphy-Ullrich, J. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47086-x · Cited by 272
Metadata
- Authors
- Olofsson, A., Miyazono, K., Kanzaki, T., Colosetti, P., Engström, U., & Heldin, C. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 267
- Issue
- 27
- Pages
- 19482-19488
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1583136467
- Cited by
- 178
- References
- 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Olofsson, A., Miyazono, K., Kanzaki, T., Colosetti, P., Engström, U., & Heldin, C. H. (1992). Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)41801-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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