Cited by 396Immune Response and InflammationProtein Kinase Regulation and GTPase SignalingNF-κB Signaling Pathways

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Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

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Weinstein, S.L., Sanghera, J.S., Lemke, K, DeFranco, A.L., Pelech, S.L.·1992·Journal of Biological Chemistry

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Abstract

Bacterial lipopolysaccharide (LPS) is a potent activator of antibacterial responses by macrophages. Following LPS stimulation, the tyrosine phosphorylation of several proteins is rapidly increased in macrophages, and this event appears to mediate some responses to LPS. We now report that two of these tyrosine phosphoproteins of 41 and 44 kDa are isoforms of mitogen-activated protein (MAP) kinase. Each of these proteins was reactive with anti-MAP kinase antibodies and comigrated with MAP kinase activity in fractions eluted from a MonoQ anion-exchange column. Following LPS stimulation, column fractions containing the tyrosine phosphorylated forms of p41 and p44 exhibited increased MAP kinase activity. Inhibition of LPS-induced tyrosine phosphorylation of these proteins was accompanied by inhibition of MAP kinase activity. Additionally, induction of p41/p44 tyrosine phosphorylation and MAP kinase activity by LPS appeared to be independent of activation of protein kinase C, even though phorbol esters also induced these responses. These results demonstrate that LPS induces the tyrosine phosphorylation and activation of at least two MAP kinase isozymes. Since MAP kinases appear to modulate cellular processes in response to extracellular signals, these kinases may be important targets for LPS action in macrophages.

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Authors: Weinstein, S. L., Sanghera, J. S., Lemke, K., DeFranco, A. L., & Pelech, S. L.
Affiliations: University of California, San Francisco (US)
Genentech (US)
ORCID: Weinstein, S.L.
DeFranco, A.L.
Pelech, S.L.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1992-07
Volume: 267
Issue: 21
Pages: 14955-14962
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)42133-3
OpenAlex: W1671728707
Cited by: 396
References: 31
Citations by year: 2026: 2 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 8
FWCI: 8.52
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10328 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI20038)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: lipopolysaccharide, macrophages, tyrosine phosphorylation, mitogen-activated protein kinase, signal transduction, phorbol ester, antibacterial response
MeSH terms: Amino Acid Sequence, Animals, Cells, Cultured, Chromatography, Ion Exchange, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Isoenzymes, Lipopolysaccharides, Macrophages, Molecular Sequence Data, Peptides, Phosphorylation, Precipitin Tests, Protein Kinase C, Protein Kinases, Quinones, Tyrosine, Blotting, Western, Benzoquinones, Rifabutin, Calcium-Calmodulin-Dependent Protein Kinases, Lactams, Macrocyclic, Protein Kinase Inhibitors, Mice

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Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

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