Cited by 396Immune Response and InflammationProtein Kinase Regulation and GTPase SignalingNF-κB Signaling Pathways

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Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

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Weinstein, S.L., Sanghera, J.S., Lemke, K, DeFranco, A.L., Pelech, S.L.·1992·Journal of Biological Chemistry

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Abstract

Bacterial lipopolysaccharide (LPS) is a potent activator of antibacterial responses by macrophages. Following LPS stimulation, the tyrosine phosphorylation of several proteins is rapidly increased in macrophages, and this event appears to mediate some responses to LPS. We now report that two of these tyrosine phosphoproteins of 41 and 44 kDa are isoforms of mitogen-activated protein (MAP) kinase. Each of these proteins was reactive with anti-MAP kinase antibodies and comigrated with MAP kinase activity in fractions eluted from a MonoQ anion-exchange column. Following LPS stimulation, column fractions containing the tyrosine phosphorylated forms of p41 and p44 exhibited increased MAP kinase activity. Inhibition of LPS-induced tyrosine phosphorylation of these proteins was accompanied by inhibition of MAP kinase activity. Additionally, induction of p41/p44 tyrosine phosphorylation and MAP kinase activity by LPS appeared to be independent of activation of protein kinase C, even though phorbol esters also induced these responses. These results demonstrate that LPS induces the tyrosine phosphorylation and activation of at least two MAP kinase isozymes. Since MAP kinases appear to modulate cellular processes in response to extracellular signals, these kinases may be important targets for LPS action in macrophages.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,876
The cell biology of macrophage activation.
Adams, D. O., & Hamilton, T. A. (1984) · Annual Review of Immunology · doi:10.1146/annurev.iy.02.040184.001435 · Cited by 1,628
Phosphorylation of c-jun mediated by MAP kinases
Pulverer, B., Kyriakis, J. M., Avruch, J., Nikolakaki, E., & Woodgett, J. R. (1991) · Nature · doi:10.1038/353670a0 · Cited by 1,470
ENDOTOXINS AND DISEASE MECHANISMS
Morrison, D. C., & Ryan, J. L. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.002221 · Cited by 1,111
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
Anderson, N. G., Maller, J. L., Tonks, N. K., & Sturgill, T. W. (1990) · Nature · doi:10.1038/343651a0 · Cited by 1,064
Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase).
Payne, D. M., Rossomando, A. J., Martino, P. A., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., & Sturgill, T. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08021.x · Cited by 1,041
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
Sturgill, T. W., Ray, L. B., ERIKSON, E., & Maller, J. L. (1988) · Nature · doi:10.1038/334715a0 · Cited by 1,017
Bacterial Endotoxins and Host Immune Responses
Morrison, D. C., & Ryan, J. L. (1980) · Advances in immunology · doi:10.1016/s0065-2776(08)60802-0 · Cited by 606

Show all 31 references

Research works printed but not linked: 4

Pabst, 1989, 6, 361
Barriere, 1991, Patient Care, 25, 95
Posada, 1991, Mol. Cell Biol., 11, 2517
Cooper, 1985, Mol. Cell Biol., 5, 3304

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Gutiérrez‐Venegas, G., Jiménez‐Estrada, M., & Maldonado-Frías, S. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.05.004 · Cited by 49
Monocyte Chemoattractant Protein-1-Induced Activation of p42/44 MAPK and c-Jun in Murine Peritoneal Macrophages: A Potential Pathway for Macrophage Activation
Sodhi, A., & Biswas, S. K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900252981990 · Cited by 49
Cynandione A attenuates neuropathic pain through p38β MAPK-mediated spinal microglial expression of β-endorphin
Huang, Q., Mao, X.-F., Wu, H., Liu, H., Sun, M., Wang, X., & Wang, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.005 · Cited by 48
Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-κB and MAPK pathways
Vitiello, M., D’Isanto, M., Galdiero, M., Raieta, K., Tortora, A., Rotondo, P., Peluso, L., & Galdiero, M. (2004) · Cytokine · doi:10.1016/j.cyto.2004.03.010 · Cited by 48
Protein kinase C regulates macrophage tumor necrosis factor secretion: Direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance
West, M. A., Lemieur, T. P., Clair, L., Bellingham, J. M., & Rodriguez, J. L. (1997) · Surgery · doi:10.1016/s0039-6060(97)90010-6 · Cited by 48
Anti-inflammatory effects of glyceollins derived from soybean by elicitation with Aspergillus sojae
Kim, H. J., Sung, M., & Kim, J. (2011) · Inflammation Research · doi:10.1007/s00011-011-0351-4 · Cited by 47
Signaling networks controlling mucin production in response to Gram-positive and Gram-negative bacteria
McNamara, N. A., & Basbaum, C. B. (2001) · Glycoconjugate Journal · doi:10.1023/a:1020875423678 · Cited by 47
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in LPS-stimulated macrophages
Delgado, M., & Ganea, D. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00359-3 · Cited by 47
Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4
Wang, Y., Cui, Y., Cao, F., Qin, Y., Li, W., & Zhang, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.05.044 · Cited by 46
Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity
Luciano, B. S., Hsu, S., Channavajhala, P. L., Lin, L., & Cuozzo, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403716200 · Cited by 46
Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene
Vogel, S. N., Wax, J. S., Perera, P., Padlan, C., Potter, M., & Mock, B. A. (1994) · Infection and Immunity · doi:10.1128/iai.62.10.4454-4459.1994 · Cited by 46
PROTEIN TYROSINE KINASE INHIBITORS DECREASE LIPOPOLYSACCHARIDE-INDUCED PROINFLAMMATORY CYTOKINE PRODUCTION IN MIXED GLIA, MICROGLIA-ENRICHED OR ASTROCYTE-ENRICHED CULTURES
Kong, L., Lai, C. C., Wilson, B. C., SIMPSON, J. N., & Hong, J. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00086-1 · Cited by 46
SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages
Hardin, A. O., Meals, E. A., Yi, T., Knapp, K. M., & English, B. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.005 · Cited by 45
Limited Role of Ceramide in Lipopolysaccharide-mediated Mitogen-activated Protein Kinase Activation, Transcription Factor Induction, and Cytokine Release
Medvedev, A. E., Blanco, J. C. G., Qureshi, N., & Vogel, S. N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9342 · Cited by 45
CD45-induced Tumor Necrosis Factor α Production in Monocytes Is Phosphatidylinositol 3-Kinase-dependent and Nuclear Factor-κB-independent
Hayes, A. L., Smith, C., Foxwell, B. M. J., & Brennan, F. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33455 · Cited by 44
Lipoteichoic acid-stimulated p42/p44 MAPK activation via Toll-like receptor 2 in tracheal smooth muscle cells
Lee, C., Chien, C., & Yang, C. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00124.2003 · Cited by 44
Impaired Mitogen-Activated Protein Kinase Activation and Altered Cytokine Secretion in Endotoxin-Tolerant Human Monocytes
Heagy, W., Hansen, C., Nieman, K. M., Rodriguez, J. L., & West, A. M. A. (2000) · doi:10.1097/00005373-200011000-00003 · Cited by 44
Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity
Lee, H. A., Koh, E. K., Sung, J. E., Kim, J. E., Song, S. H., Kim, D. S., Son, H. J., Lee, C. Y., Lee, H. S., Bae, C. J., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6166 · Cited by 43
Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK duringToxoplasma gondiiinvasion
Valere, A., Garnotel, R., Villena, I., Guenounou, M., Pinon, J. M., & Aubert, D. (2003) · Parasite · doi:10.1051/parasite/2003101p59 · Cited by 43
Induction of cyclooxygenase-2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-κB pathways
Luo, S., Wang, C., Chien, C., Hsiao, L., & Yang, C. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00135-3 · Cited by 43
Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors
Malcolm, K. C., & Worthen, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212033200 · Cited by 42
Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production
Brooks, A. C., Menzies‐Gow, N. J., Wheeler-Jones, C. P. D., Bailey, S. R., Cunningham, F. M., & Elliott, J. (2007) · Inflammation Research · doi:10.1007/s00011-006-6151-6 · Cited by 42
Hck Enhances the Adherence of Lipopolysaccharide-stimulated Macrophages via Cbl and Phosphatidylinositol 3-Kinase
Scholz, G. M., Cartledge, K., & Dunn, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14615 · Cited by 42
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei
Gale, M., Carter, V., & Parsons, M. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.7.1825 · Cited by 41
Association of mitogen-activated protein kinases with microtubules in mouse macrophages.
Ding, A. H., Chen, B., Fuortes, M. G., & Blum, E. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1899 · Cited by 40
Inulin stimulates NO synthesis via activation of PKC-α and protein tyrosine kinase, resulting in the activation of NF-κB by IFN-γ-primed RAW 264.7 cells
Koo, H., Hong, S., Seo, H.-G., Yoo, T.-S., Lee, K.-N., Kim, N.-S., Kim, C., & Kim, H. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.07.002 · Cited by 39
Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway
Kasahara, E., Sekiyama, A., Hori, M., Hara, K., Takahashi, N., Konishi, M., Sato, E. F., Matsumoto, S., Okamura, H., & Inoue, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.049 · Cited by 39
Biological Characterization of Endotoxins Released from Antibiotic-TreatedPseudomonas aeruginosaandEscherichia coli
Kirikae, T., Kirikae, F., Saito, S., Tominaga, K., Tamura, H., Uemura, Y., Yokochi, T., & Nakano, M. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.5.1015 · Cited by 39

Authors: Weinstein, S. L., Sanghera, J. S., Lemke, K., DeFranco, A. L., & Pelech, S. L.
Affiliations: University of California, San Francisco (US)
Genentech (US)
ORCID: Weinstein, S.L.
DeFranco, A.L.
Pelech, S.L.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1992-07
Volume: 267
Issue: 21
Pages: 14955-14962
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)42133-3
OpenAlex: W1671728707
Cited by: 396
References: 31
Citations by year: 2026: 2 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 8
FWCI: 8.52
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10328 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI20038)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: lipopolysaccharide, macrophages, tyrosine phosphorylation, mitogen-activated protein kinase, signal transduction, phorbol ester, antibacterial response
MeSH terms: Amino Acid Sequence, Animals, Cells, Cultured, Chromatography, Ion Exchange, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Isoenzymes, Lipopolysaccharides, Macrophages, Molecular Sequence Data, Peptides, Phosphorylation, Precipitin Tests, Protein Kinase C, Protein Kinases, Quinones, Tyrosine, Blotting, Western, Benzoquinones, Rifabutin, Calcium-Calmodulin-Dependent Protein Kinases, Lactams, Macrocyclic, Protein Kinase Inhibitors, Mice

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Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

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