The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.
Open accessAbstract
Resistance against the cytotoxic actions of tumor necrosis factor alpha (TNF) is an active process requiring the synthesis of TNF-inducible proteins. The specific TNF-induced proteins so far identified (manganese superoxide dismutase and plasminogen activator inhibitor type 2) as having a role in resistance against TNF cytotoxicity are able to confer only partial protection to cells, suggesting that other genes are involved. A20 is a TNF-induced primary response gene which encodes a novel zinc finger protein. In this report we demonstrate that A20 protein is induced by TNF in a variety of cells. A survey of A20 expression in human breast carcinoma cell lines that are either sensitive or resistant to TNF cytotoxicity revealed increased expression of A20 message and protein in TNF-resistant cells. Constitutive expression of A20 after stable transfection of NIH 3T3 and WEHI 164 cells results in significant, but partial, resistance to TNF cytotoxicity. This work gives additional support to a role for TNF-induced immediate early response genes in protecting cells from TNF-induced death.
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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
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Metadata
- Authors
- Opipari, A. W., Hu, H. M., Yabkowitz, R., & Dixit, V. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 267
- Issue
- 18
- Pages
- 12424-12427
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1521689717
- Cited by
- 434
- References
- 20
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Opipari, A. W., Hu, H. M., Yabkowitz, R., & Dixit, V. M. (1992). The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)42292-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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