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Cited by 122Adipose Tissue and MetabolismLipid metabolism and biosynthesisMitochondrial Function and Pathology

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis

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Bukowiecki, L.J., Folléa, N, Lupien, J, Paradis, A·1981·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)42972-9
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Abstract

The calorigenic action of norepinephrine in isolated brown adipocytes was selectively mimicked by theophylline, dibutyryl cyclic AMP, and the principal fatty acids known to be present in the acyl moieties of brown adipose tissue triglycerides (palmitic, oleic, and linoleic acids). The stimulatory effects of fatty acids were entirely reversible, occurred at physiological concentrations, and were critically dependent upon the molar ratio of extracellular fatty acids to albumin. The calorigenic potency of fatty acids increased with their chain length. The apparent synchrony between the switching "on and off" of lipolysis and respiration by norepinephrine and propranolol indicated that the two phenomena are functionally inter-related and that they are both mediated by beta-adrenoreceptors. Respiratory stimulation by palmitic acid was accompanied by an inhibition of glycerol release suggesting that fatty acids retroinhibit lipolysis while simultaneously activating respiration. Studies with 2-tetradecylglycidic acid, oligomycin, and uncouplers of oxidative phosphorylation support the view that fatty acids exert their calorigenic effects by increasing mitochondrial proton permeability and by simultaneously serving as substrates for beta-oxidation via carnitine-dependent pathways. Since fatty acids mimicked the calorigenic action of norepinephrine even when beta-adrenoreceptors were blocked by propranolol, it is concluded that cyclic AMP controls respiration indirectly, most probably by modulating lipolysis. It is suggested that endogenous long chain fatty acids released in consequence of cyclic AMP activation of lipolysis play a fundamental role in the control of brown adipose tissue metabolism by self-regulating lipolysis and by serving as physiological modulators of mitochondrial oxygen consumption.

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Crossref · 10.1016/s0021-9258(18)42972-9

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Citations

Cites

Research works printed but not linked: 6

  1. Heaton, 1972, J. Anat., 112, 35
  2. Himms-Hagen, 1979, Can. Med. Assoc. J., 121, 1361
  3. Bukowiecki, 1980, Am. J. Physiol., 238, E552
  4. Bukowiecki, L., Folléa, N., Paradis, A., and LeBlanc, J. (1979) Proceedings of the XIth International Congress of Biochemistry, Toronto, July 8–13, p. 620
  5. Edelman, 1974, Recent Prog. Hormone Res., 30, 235
  6. Ricquier, D. (1979) Doctorate thesis, Pierre and Marie Curie University, Paris

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Metadata

Authors
Bukowiecki, L. J., Folléa, N., Lupien, J., & Paradis, A.
Affiliations
Université Laval (CA)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1981-12
Volume
256
Issue
24
Pages
12840-12848
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)42972-9
OpenAlex
W1494515526
Cited by
122
References
37
Citations by year
2026: 3 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 1
FWCI
7.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
brown adipocytes, lipolysis, mitochondrial respiration, long-chain fatty acids, norepinephrine, beta-adrenergic receptors, cyclic AMP, palmitic acid, calorigenic effect, glycerol release, fatty acid beta-oxidation, L-carnitine, propranolol, theophylline, dibutyryl cyclic AMP, fatty acid chain length, mitochondrial oxygen consumption
MeSH terms
Animals, Adipose Tissue, Brown, Bucladesine, Fatty Acids, Nonesterified, Female, Kinetics, Lipid Mobilization, Mitochondria, Norepinephrine, Oxygen Consumption, Palmitic Acids, Propranolol, Rats, Inbred Strains, Structure-Activity Relationship, Theophylline, Palmitic Acid, Rats

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