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Cited by 135Regulation of Appetite and ObesityAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings

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Thurlby, P. L., Trayhurn, P.·1979·British Journal of Nutrition
DOI 10.1079/bjn19790127
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Abstract

1. In order to quantitatively assess the energetic significance of reduced thermoregulatory thermogenesis in the accumulation of excess body fat in genetically-obese (ob/ob) mice experiments have been conducted at four environmental temperatures (17, 23, 28 and 33°) in which young growing obese animals were pair-fed for 10 d to the ad lib. intake of lean siblings. 2. The food intake of the lean mice increased with decreasing environmental temperature: at 17° the intake was 86% higher than that at 33°. 3. The estimated gain in carcass energy of lean mice rose with increasing temperature, from 82 kJ at 17° to 150 kJ at 33°. The energy gain of the pair-fed obese mice was higher than that of the lean at all temperatures but showed a slight decrease with increasing temperature, from 231 kJ at 17° to 191 kJ at 33°. 4. Environmental temperature affected the ‘excess’ energy gain of the obese mice. At 17° the obese mice deposited 182% more energy than the lean but this difference decreased progressively with increasing temperature to 127, 62 and 27% more energy at 23, 28 and 33° respectively. 5. At all environmental temperatures the pair-fed obese mice deposited considerably less protein than their lean controls. The deposition ranged from 32% (at 17°) to 56% (at 28°) of that of the lean mice. 6. It is concluded that environmental temperature plays a major role in determining the excess energy gain of ob/ob mice receiving the same amount of food as lean controls, and that the low energy expenditure and consequent high metabolic efficiency of this mutant is due primarily to reduced thermoregulatory thermogenesis.

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  • Obesity resulting from genetic disruption in leptin signaling is not necessarily mediated exclusively through hunger and energy intake; the ob/ob mouse has markedly increased adiposity even when energy-restricted to prevent excessive weight gain.

    “In one extensively studied example, obesity resulting from genetic disruption in leptin signaling is not necessarily mediated exclusively through hunger and energy intake; the ob/ob mouse has markedly increased adiposity even when energy-restricted to prevent excessive weight gain (136).”

    From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [136]

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Research works printed but not linked: 2

  1. Thurlby, P. L., Trayhurn, P. &James, W. P. T. (1978). Proc. Nurr. SOC. 37, 55 A.
  2. Trayhurn, P. &James, W. P. T. (1978). Pflugers Arch. ges. Physiol. 373, 189. https://doi.org/10.1079/BJN19790127 Published online by Cambridge University Press · DOI

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Authors
Thurlby, P. L., & Trayhurn, P.
Affiliations
University of Cambridge (GB)
ORCID
Trayhurn, P.
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
1979-11
Volume
42
Issue
3
Pages
377-385
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1079/bjn19790127
OpenAlex
W2077068997
Cited by
135
References
17
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2013: 4
FWCI
5.47
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 9990 d)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
obesity, ob/ob mice, pair feeding, ambient temperature, energy expenditure, energy deposition, protein deposition, dietary intake, metabolic efficiency, body fat accumulation
MeSH terms
Animals, Body Composition, Body Temperature Regulation, Energy Intake, Energy Metabolism, Mice, Obese, Obesity, Proteins, Temperature, Lipid Metabolism, Mice

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