Cited by 263Nitric Oxide and Endothelin EffectsBiochemical and Molecular ResearchFolate and B Vitamins Research

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.

Open access

Werner-Felmayer, G., Werner, E.R., Fuchs, D., Hausen, A., Reibnegger, G., Schmidt, K., Weiss, G., Wachter, H.·1993·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)53931-4

Open this paper in CoChat — free account

Abstract

Stimulation of nitric oxide (NO) synthase in endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP. NO synthase from various sources is known to use tetrahydrobiopterin, flavins, and NADPH as cofactors. We studied the effect of interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide on tetrahydrobiopterin biosynthetic activities in human umbilical vein endothelial cells (HUVEC). These stimuli led to an up to 40-fold increase of GTP cyclohydrolase I (EC 3.5.4.16) activity and to increased accumulation of neopterin and tetrahydrobiopterin in HUVEC. Further enzyme activities of tetrahydrobiopterin biosynthesis, i.e. 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), remained unchanged. NO synthase activity in protein fractions from homogenates of cells treated with interferon-gamma plus tumor necrosis factor-alpha was not influenced as compared with untreated controls. However, interferon-gamma alone or in combination with tumor necrosis factor-alpha significantly increased intracellular cGMP formation in intact HUVEC by 50 and 80%, respectively. These stimuli increased intracellular tetrahydrobiopterin concentrations up to 14-fold. NO-triggered cGMP formation was similarly increased by incubation of otherwise untreated cells with sepiapterin, leading to elevated intracellular tetrahydrobiopterin levels. Thus, cytokines indirectly stimulate the activity of constitutive NO synthase in HUVEC by upregulating production of the cofactor tetrahydrobiopterin.

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)53931-4

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.10043 · Cited by 1,097
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816
Analysis of reduced forms of biopterin in biological tissues and fluids
Fukushima, T., & Nixon, J. C. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90336-x · Cited by 714

Show all 50 references

Research works printed but not linked: 2

Werner-Felmayer, 1990, Cancer Res., 50, 2863
Brown, 1989, Cancer Res., 49, 4941

Sorted by citations

Items 101–200 of 263

Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus
Sasaki, N., Yamashita, T., Takaya, T., Shinohara, M., Shiraki, R., Takeda, M., Emoto, N., Fukatsu, A., Hayashi, T., Ikemoto, K., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160754 · Cited by 56
Anoxia/Reoxygenation-Induced Tolerance With Respect to Polymorphonuclear Leukocyte Adhesion to Cultured Endothelial Cells
Cepinskas, G., Lush, C. W., & Kvietys, P. R. (1999) · Circulation Research · doi:10.1161/01.res.84.1.103 · Cited by 53
Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism
Gesierich, A., Niroomand, F., & Tiefenbacher, C. (2003) · Basic Research in Cardiology · doi:10.1007/s00395-003-0394-y · Cited by 53
Endothelial Activation by Cytokinesa
Mantovani, A., Sozzani, S., & Introna, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46240.x · Cited by 54
Blockade of Tetrahydrobiopterin Synthesis Protects Neurons after Transient Forebrain Ischemia in Rat: A Novel Role for the Cofactor
Cho, S., Volpe, B. T., Bae, Y. M., Hwang, O., Choi, H. J., Gál, J., Park, L. C. H., Chu, C. K., Du, J., & JOH, T. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-00878.1999 · Cited by 53
DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin
Sheng, J., Wang, D., & Braun, A. P. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087932 · Cited by 50
Pteridine biosynthesis and nitric oxide synthase in Physarum polycephalum
Werner‐Felmayer, G., Golderer, G., Werner, E. R., Gröbner, P., & WACHTER, H. (1994) · Biochemical Journal · doi:10.1042/bj3040105 · Cited by 51
Self-citation
Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis
Moat, S. J., Clarke, Z. L., Madhavan, A. K., LEWIS, M. J., & Lang, D. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.11.047 · Cited by 50
Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone
Kinoshita, H., Tsutsui, M., Milstien, S., & Katušić, Z. S. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00017-8 · Cited by 50
Obesity-related inflammation & cardiovascular disease: efficacy of a yoga-based lifestyle intervention.
Sarvottam, K., & Yadav, R. K. (2014) · Europe PMC (PubMed Central) · Cited by 51
Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts
Yamashiro, S., Noguchi, K., Matsuzaki, T., Miyagi, K., Nakasone, J., Sakanashi, M., Koja, K., & Sakanashi, M. (2002) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2002.124393 · Cited by 48
Tetrahydrobiopterin levels regulate endothelial cell proliferation
MARINOS, R. S., Zhang, W., Wu, G., Kelly, K. A., & Meininger, C. J. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.2.h482 · Cited by 48
Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat
Werner‐Felmayer, G., Prast, H., Werner, E. R., Philippu, A., & Wächter, H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81574-j · Cited by 48
Self-citation
Nitric oxide, an iceberg in cardiovascular physiology:
Rubio, A. R., & Morales-Segura, M. A. (2004) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.09.011 · Cited by 46
Role of Tetrahydrobiopterin Availability in the Regulation of Nitric-oxide Synthase Expression in Human Mesangial Cells
Saura, M., Pérez‐Sala, D., Cañada, F. J., & Lamas, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14290 · Cited by 47
Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting endothelial cell phagocytosis
Fratti, R. A., Ghannoum, M. A., Edwards, J. E., & Filler, S. G. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4714-4718.1996 · Cited by 46
Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide—A role for GFRP?
Kalivendi, S. V., Hatakeyama, K., Whitsett, J., Konorev, E. A., Kalyanaraman, B., & Vasquez-Vivar, J. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.004 · Cited by 45
Biosynthesis of nitric oxide: Dependence on pteridine metabolism
Werner, E. R., Werner‐Felmayer, G., WACHTER, H., & Mayer, B. (1995) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0048266 · Cited by 44
Self-citation
Neopterin and quinolinic acid are surrogate measures of disease activity in the juvenile idiopathic inflammatory myopathies.
Rider, L. G., Schiffenbauer, A. S., Zito, M. A., Lim, K. L., Ahmed, A. E. E., Zemel, L. S., Rennebohm, R. M., Passo, M. H., Summers, R. M., Hicks, J. E., et al. (2002) · PubMed · Cited by 43
Modulation of Inducible Nitric Oxide Synthase mRNA Stability by Tetrahydrobiopterin in Vascular Smooth Muscle Cells
Linscheid, P., Schaffner, A., & Schoedon, G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8072 · Cited by 44
Regulation of 6-Pyruvoyltetrahydropterin Synthase Activity and Messenger RNA Abundance in Human Vascular Endothelial Cells
Linscheid, P., Schaffner, A., Blau, N., & Schoedon, G. (1998) · Circulation · doi:10.1161/01.cir.98.17.1703 · Cited by 43
Regulation of nitric oxide synthase and soluble guanylyl cyclase
Mayer, B. (1994) · Cell Biochemistry and Function · doi:10.1002/cbf.290120304 · Cited by 43
Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
Gütlich, M., Jaeger, E., RÜCKNAGEL, K. P., Werner, T., Rödl, W., Ziegler, I., & Bacher, A. (1994) · Biochemical Journal · doi:10.1042/bj3020215 · Cited by 43
Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production
Kar, S., & Kavdia, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.009 · Cited by 42
Splanchnic and Systemic Vasodilation
Wiest, R. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318157cb57 · Cited by 42
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1β-stimulated rat glomerular mesangial cells
Mühl, H., & Pfeilschifter, J. M. (1994) · Kidney International · doi:10.1038/ki.1994.398 · Cited by 42
Serum Neopterin and Activity of Coronary Artery Disease
Auer, J., Berent, R., Lanig, E., & Eber, B. (2001) · Heart Disease · doi:10.1097/00132580-200109000-00004 · Cited by 40
Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase–serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution
Whitsett, J., Pavel Martasek, E., Zhao, H., Schauer, D. W., Hatakeyama, K., Kalyanaraman, B., & Vasquez-Vivar, J. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.001 · Cited by 39
Impaired Vasodilation and Nitric Oxide Synthase Activity in Glucocorticoid-Induced Hypertension
Mitchell, B. M., & Webb, R. C. (2002) · Biological Research For Nursing · doi:10.1177/1099800402004001003 · Cited by 38
Molecular mechanisms of estrogen actions on the vasculature
Haynes, M. P., Russell, K. S., & Bender, J. R. (2000) · Journal of Nuclear Cardiology · doi:10.1067/mnc.2000.109958 · Cited by 38
Interaction between reactive oxygen metabolites and nitric oxide in oxidant tolerance1,2 1This article is part of a series of reviews on “Vascular Dysfunction and Free Radicals.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Toshikazu Yoshikawa
Cepinskas, G., Rui, T., & Kvietys, P. R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00962-0 · Cited by 37
The regulation of dopamine release from striatum slices by tetrahydrobiopterin and l-arginine-derived nitric oxide
Li, L., & Kaufman, S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00452-1 · Cited by 37
Biochemistry and Molecular Pharmacology of Nitric Oxide Synthases
Mayer, B. (1995) · Elsevier eBooks · doi:10.1016/b978-012721985-1/50004-6 · Cited by 37
Interleukin 1β and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells
Plüss, C., Werner, E. R., Blau, N., Wächter, H., & Pfeilschifter, J. M. (1996) · Biochemical Journal · doi:10.1042/bj3180665 · Cited by 34
Self-citation
GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats
Mitchell, B. M., Dorrance, A. M., & Webb, R. C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00253.2003 · Cited by 33
GTP cyclohydrolase I mRNA induction and tetrahydrobiopterin synthesis in human endothelial cells
Hattori, Y., Nakanishi, N., Kasai, K., & Shimoda, S.-I. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00052-9 · Cited by 33
Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease
Yadav, A. K., Sharma, V., & Jha, V. (2012) · Mediators of Inflammation · doi:10.1155/2012/476979 · Cited by 32
Tetrahydrobiopterin, a Critical Factor in the Production and Role of Nitric Oxide in Mast Cells
Gilchrist, M., Heßlinger, C., & Befus, A. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307777200 · Cited by 31
Phenylalanine Improves Dilation and Blood Pressure in GTP Cyclohydrolase Inhibition-Induced Hypertensive Rats
Mitchell, B. M., Dorrance, A. M., & Webb, R. C. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200406000-00004 · Cited by 31
Molecular characteristics and enzymology of nitric oxide synthase and soluble guanylyl cyclase in the CNS
Mayer, B. (1993) · Seminars in Neuroscience · doi:10.1016/s1044-5765(05)80053-3 · Cited by 30
Serum level and prognostic value of neopterin in patients after ischemic stroke
Lin, H.-S., Tsai, T., Liu, C.-F., Lu, C., Chang, W., Chen, S., Huang, C.-W., Huang, C., Tsai, N., Huang, C., et al. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.07.113 · Cited by 29
α-Tocopherol Amplifies Phosphorylation of Endothelial Nitric Oxide Synthase at Serine 1177 and its Short-Chain Derivative Trolox Stabilizes Tetrahydrobiopterin
Heller, R., Hecker, M., Stahmann, N., Thiele, J. J., Werner‐Felmayer, G., & Werner, E. R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.017 · Cited by 28
Self-citation
Chronic Ethanol Exposure Stimulates Endothelial Cell Nitric Oxide Production through PI-3 Kinase-and hsp90-dependent Mechanisms
Polikandriotis, J. A., Rupnow, H. L., & Hart, C. M. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000187597.62590.a4 · Cited by 28
Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA
Hattori, Y., Oka, M., Kasai, K., Nakanishi, N., & Shimoda, S.-I. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00689-7 · Cited by 29
Impact of SOD in eNOS uncoupling: a two-edged sword between hydrogen peroxide and peroxynitrite
Kar, S., Bhandar, B., & Kavdia, M. (2012) · Free Radical Research · doi:10.3109/10715762.2012.731052 · Cited by 27
Tetrahydrobiopterin: Mediator of Endothelial Protection
Katušić, Z. S., & d’Uscio, L. V. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000121569.76931.0b · Cited by 27
Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia
Leiva, A., Fuenzalida, B., Salsoso, R., Barros, E., Toledo, F., Gutiérrez, J., Pardo, F., & Sobrevía, L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.021 · Cited by 27
Reduction by Tetrahydrobiopterin of H2O2–Induced Endothelial Cell Injury
Ishii, M., Shimizu, S., Momose, K., & Yamamoto, T. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01574.x · Cited by 26
Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection
Xie, L., Talukder, M. A. H., Sun, J., Varadharaj, S., & Zweier, J. L. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.06.015 · Cited by 25
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
Schmidt, K., Kolesnik, B., Gorren, A. C. F., Werner, E. R., & Mayer, B. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.05.010 · Cited by 24
Self-citation
Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea
Ursavaş, A., Karadağ, M., Oral, A. Y., Demirdöğen, E., Oral, H. B., & Eğe, E. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.02.019 · Cited by 24
Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells
Meda, C., Plank, C., Mykhaylyk, O. M., Schmidt, K., & Mayer, B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70247-4 · Cited by 24
Self-citation
GTP Cyclohydrolase I Is Coinduced in Hepatocytes Stimulated to Produce Nitric Oxide
Geller, D. A., Silvio, M. D., Billiar, T. R., & Hatakeyama, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3537 · Cited by 23
Molecular Regulation of Inducible Nitric Oxide Synthase
Ganster, R. W., & Geller, D. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50009-5 · Cited by 23
Human endothelial cells are activated by interferon‐γ plus tumour necrosis factor‐α to kill intracellular Pseudomonas aeruginosa
de Assis, M. C., Costa, A. O., Barja-Fidalgo, T. C., & Plotkowski, M. C. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00102.x · Cited by 22
Nitric Oxide: Physiological Roles, Biosynthesis and Medical Uses
Adams, D. R., Brochwicz‐Lewinski, M., & BUTLER, A. R. (1999) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-6351-1_1 · Cited by 23
Urinary neopterin and nitric oxide metabolites as markers of interferon β-1a activity in primary progressive multiple sclerosis
Rejdak, K., Leary, S. M., Petzold, A., Thompson, A. J., Miller, D., & Giovannoni, G. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510375100 · Cited by 22
Role of neopterin as a biochemical marker for peripheral neuropathy in pediatric patients with type 1 diabetes: Relation to nerve conduction studies
Elbarbary, N. S., Ismail, E. A. R., Hilaly, R. E., & Ahmed, F. S. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.026 · Cited by 21
Comparison of Tetrahydrobiopterin and L-Arginine on Cerebral Blood Flow after Controlled Cortical Impact Injury in Rats
Cherian, L., Hlatky, R., & Robertson, C. S. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1196 · Cited by 21
Dual Mechanism of Signal Transducer and Activator of Transcription 5 Activation by the Insulin Receptor
Le, M. N., Kohanski, R. A., Wang, L., & Sadowski, H. B. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0017 · Cited by 21
Prognostic significance of immune activation after acute coronary syndromes
Auer, J., Berent, R., Laßnig, E., Weber, T., & Eber, B. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01875-2 · Cited by 21
Nitric oxide and biopterin: a study in Chiaroscuro.
Nathan, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117176 · Cited by 21
Human Dermal Microvascular Endothelial Cells Express Inducible Nitric Oxide Synthase In Vitro
HOFFMANN, G. E., Rieder, J., Smolny, M., Seibel, M., Schobersberger, W., Fürhapter, C., Fritsch, P. O., & Sepp, N. T. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00505.x · Cited by 20
Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization
Park, J.-H., Na, H.-J., Kwon, Y., Ha, K., Lee, S., Kim, C., Lee, K.-S., Yoneyama, T., Hatakeyama, K., Kim, P. K. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207053200 · Cited by 20
Molecular Regulation of Inducible Nitric Oxide Synthase
Du, Q., & Geller, D. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00008-3 · Cited by 20
Relations between Concentrations of Asymmetric Dimethylarginine and Neopterin as Potential Risk Factors for Cardiovascular Diseases in Haemodialysis-Treated Patients
Avcı, E., Cevher, Ş. C., Çakır, E., Kurt, Y., Akgül, E. Ö., & Bilgi, C. (2008) · Renal Failure · doi:10.1080/08860220802249009 · Cited by 19
Tetrahydrobiopterin and Related Biologically Important Pterins
Murata, S., Ichinose, H., & Urano, F. (2007) · Springer eBooks · doi:10.1007/7081_2007_061 · Cited by 21
Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation
Cook, I. T., Wang, T., & Leyh, T. S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704500114 · Cited by 22
The fine cytokine line between graft acceptance and rejection
Holzknecht, Z. E., & Platt, J. L. (2000) · Nature Medicine · doi:10.1038/74963 · Cited by 19
Nitric Oxide Production by Decidual Endothelial Cells is not Reduced in Preeclampsia
Rowe, J., Campbell, S., & Gallery, E. D. M. (2003) · Hypertension in Pregnancy · doi:10.1081/prg-120017005 · Cited by 19
Relation between Cyclic GMP Generation and Cerebrovascular Reactivity: Modulation by NPY and α‐Trinositol
You, J., Zhang, W., Jansen‐Olesen, I., & Edvinsson, L. I. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb01913.x · Cited by 17
Review: Role of Neopterin and 7,8-Dihydroneopterin in Human Immunodeficiency Virus Infection: Marker for Disease Progression and Pathogenic Link
Baier‐Bitterlich, G., Wächter, H., & Fuchs, D. (1996) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199610010-00010 · Cited by 18
Self-citation
Discovery of mammalian genes that participate in virus infection
Organ, E. L., Sheng, J., Ruley, H. E., & Rubin, D. H. (2004) · BMC Cell Biology · doi:10.1186/1471-2121-5-41 · Cited by 17
The Coronary Microcirculation in Health and Disease
Muller‐Delp, J. M. (2013) · ISRN Physiology · doi:10.1155/2013/238979 · Cited by 17
High-performance liquid chromatographic methods for the quantification of tetrahydrobiopterin biosynthetic enzymes
Werner, E. R., Werner‐Felmayer, G., & WACHTER, H. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00507-2 · Cited by 17
Self-citation
Dexamethasone Inhibits Nitric Oxide Synthase mRNA Induction by Interleukin-la and Tumor Necrosis Factor-α in Vascular Smooth Muscle Cells
Marumo, T., Nakaki, T., Nagata, K., Miyata, M., Adachi, H., Esumi, H., Suzuki, H., Saruta, T., & Kato, R. (1993) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.63.361 · Cited by 17
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta
Kukor, Z., Mészáros, G., HERTELENDY, F., & Tóth, M. (1996) · Placenta · doi:10.1016/s0143-4004(05)80645-9 · Cited by 18
Neopterin—a forgotten biomarker
Kaski, J. C., y, P. A., & Arroyo‐Espliguero, R. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00894-5 · Cited by 17
Inducible Nitric Oxide Synthase Activity in Hepatocytes is Dependent on the Coinduction of Tetrahydrobiopterin Synthesis
Silvio, M. D., Geller, D. A., Gross, S. S., Nussler, A. K., Freeswick, P. D., Simmons, R. L., & Billiar, T. R. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2960-6_63 · Cited by 17
Thalidomide Improves the Intestinal Mucosal Injury and Suppresses Mesenteric Angiogenesis and Vasodilatation by Down-Regulating Inflammasomes-Related Cascades in Cirrhotic Rats
Li, T., Huang, C., Yang, Y., Lee, K., Hsieh, S.-L., Hsieh, Y., Alan, L., Lin, H., Lee, S., & Tsai, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147212 · Cited by 16
The regulation of vascular tetrahydrobiopterin bioavailability
Starr, A., Hussein, D. A., & Nandi, M. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.08.002 · Cited by 16
Gamma Interferon Is Dispensable for Neopterin Production In Vivo
Sghiri, R., Feinberg, J. M., Thabet, F. C., Dellagi, K., Boukadida, J., Abdelaziz, A. B., Casanova, J., & Barbouche, M. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.12.1437-1441.2005 · Cited by 16
Effect of septicaemia on the plasma levels of biopterin and nitric oxide metabolites in rats and rabbits
van Amsterdam, J., van den Berg, C., Zuidema, J., Biesebeek, J. D. T., & Rokos, H. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00511-4 · Cited by 16
Interleukin-1β: A common cause of alzheimer's disease and diabetes mellitus
Holden, R. J., & Mooney, P. A. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90240-6 · Cited by 15
Induction of tetrahydrobiopterin synthesis in human umbilical vein smooth muscle cells by inflammatory stimuli
Walter, R. B., Linscheid, P., Blau, N., Kierat, L., Schaffner, A., & Schoedon, G. (1998) · Immunology Letters · doi:10.1016/s0165-2478(97)00123-5 · Cited by 15
Interactions between nitric oxide and sphingolipids and the potential consequences in physiology and pathology
Clementi, E., Borgese, N., & Meldolesi, J. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.08.008 · Cited by 15
Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling
Panday, S., Kar, S., & Kavdia, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.07.001 · Cited by 14
High-performance liquid chromatographic measurement of cerebrospinal fluid tetrahydrobiopterin, neopterin, homovanillic acid and 5-hydroxindoleacetic acid in neurological diseases
Candito, M., Nagatsu, T., Chambon, P., & Chatel, M. (1994) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(94)80070-7 · Cited by 14
Increased plasma tetrahydrobiopterin in septic shock is a possible therapeutic target
Hoshiai, K., Hattan, N., Fukuyama, N., Tadaki, F., Hida, M., Saitō, A., Nakanishi, N., Hattori, Y., & Nakazawa, H. K. (2001) · Pathophysiology · doi:10.1016/s0928-4680(00)00063-8 · Cited by 13
Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction
Pannirselvam, M., Anderson, T. J., & Triggle, C. R. (2003) · Drug Development Research · doi:10.1002/ddr.10127 · Cited by 13
Elevated Levels of Neopterin in Sleep-Disordered Breathing
Punjabi, N. M., Beamer, B. A., Jain, A., Spencer, M. E., & Fedarko, N. S. (2007) · CHEST Journal · doi:10.1378/chest.07-0743 · Cited by 12
N-Acetylserotonin prevents the hypotension induced by bacterial lipopolysaccharides in the rat
Klemm, P. L., Ostrowski, J., Morath, T., Gruber, C., Martorana, P. A., & Henning, R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90651-w · Cited by 12
GTP cyclohydrolase I utilizes metal‐free GTP as its substrate
Suzuki, T., Kurita, H., & Ichinose, H. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03933.x · Cited by 11
Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall:Early and Late Ascorbic Acid Supplementation
Sridulyakul, P., Wongeakin, N., & Patumraj, S. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/709695 · Cited by 11
Modulation of Nitric Oxide Synthase Activity in Intact Cells by Intracellular Tetrahydrobiopterin Levels
Werner‐Felmayer, G., Werner, E. R., Weiß, G., & Wächter, H. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2960-6_64 · Cited by 11
Self-citation
Stimulation of Tetrahydrobiopterin Synthesis by Cytokines in Human and in Murine Cells
Werner, E. R., Werner‐Felmayer, G., Weiß, G., & WACHTER, H. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2960-6_41 · Cited by 11
Self-citation
Increasing tetrahydrobiopterin in cardiomyocytes adversely affects cardiac redox state and mitochondrial function independently of changes in NO production
Sethumadhavan, S., Whitsett, J., Bennett, B., Ionova, I. A., Pieper, G. M., & Vasquez-Vivar, J. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.019 · Cited by 10
Animal Models of Hypertension
Mitchell, B. M., Wallerath, T., & Förstermann, U. (2007) · Methods in molecular medicine · doi:10.1007/978-1-59745-571-8_6 · Cited by 10
Tetrahydrobiopterin in the vascular system
Walter, R. B., Schaffner, A., & Schoedon, G. (2001) · Pteridines · doi:10.1515/pteridines.2001.12.3.93 · Cited by 10
Inhibition of endotoxin‐induced vascular hyporeactivity by 4‐amino‐tetrahydrobiopterin
Gibraeil, H. D., Dittrich, P., Saleh, S., & Mayer, B. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703752 · Cited by 10

Authors: Werner-Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G., Schmidt, K., Weiss, G., & Wachter, H.
Affiliations: Universität Innsbruck (AT)
ORCID: Werner, E.R.
Fuchs, D.
Reibnegger, G.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1993-01
Volume: 268
Issue: 3
Pages: 1842-1846
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)53931-4
OpenAlex: W1496789829
Cited by: 263
References: 50
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 13.33
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10146 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Keywords: pteridine synthesis, tetrahydrobiopterin, nitric oxide synthase, cyclic GMP, endothelial cells, GTP cyclohydrolase I, interferon-gamma, TNF-α, lipopolysaccharide, neopterin, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, sepiapterin
MeSH terms: Amino Acid Oxidoreductases, Biopterins, Cells, Cultured, Endothelium, Vascular, GTP Cyclohydrolase, Cyclic GMP, Humans, Hypoxanthines, Interferon-gamma, Lipopolysaccharides, Nitric Oxide, Pteridines, Pterins, Tumor Necrosis Factor-alpha, Umbilical Veins, Nitric Oxide Synthase, Neopterin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks