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Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
Open accessAbstract
Stimulation of nitric oxide (NO) synthase in endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP. NO synthase from various sources is known to use tetrahydrobiopterin, flavins, and NADPH as cofactors. We studied the effect of interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide on tetrahydrobiopterin biosynthetic activities in human umbilical vein endothelial cells (HUVEC). These stimuli led to an up to 40-fold increase of GTP cyclohydrolase I (EC 3.5.4.16) activity and to increased accumulation of neopterin and tetrahydrobiopterin in HUVEC. Further enzyme activities of tetrahydrobiopterin biosynthesis, i.e. 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), remained unchanged. NO synthase activity in protein fractions from homogenates of cells treated with interferon-gamma plus tumor necrosis factor-alpha was not influenced as compared with untreated controls. However, interferon-gamma alone or in combination with tumor necrosis factor-alpha significantly increased intracellular cGMP formation in intact HUVEC by 50 and 80%, respectively. These stimuli increased intracellular tetrahydrobiopterin concentrations up to 14-fold. NO-triggered cGMP formation was similarly increased by incubation of otherwise untreated cells with sepiapterin, leading to elevated intracellular tetrahydrobiopterin levels. Thus, cytokines indirectly stimulate the activity of constitutive NO synthase in HUVEC by upregulating production of the cofactor tetrahydrobiopterin.
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“Increased NOX1 activity is associated with vascular disease, and studies have shown links between high NOX1 levels and hypertension (1015), diabetes (163, 380, 1003), ischemia/reperfusion injury (479), and coronary artery disease (393).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1003]
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.10043 · Cited by 1,097
Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816
Analysis of reduced forms of biopterin in biological tissues and fluids
Fukushima, T., & Nixon, J. C. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90336-x · Cited by 714
Research works printed but not linked: 2
- Werner-Felmayer, 1990, Cancer Res., 50, 2863
- Brown, 1989, Cancer Res., 49, 4941
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Kaspers, B., Gütlich, M., Witter, K., Lösch, U., Goldberg, M., & Ziegler, I. (1997) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(96)00315-x · Cited by 9
Shiraishi, H., Kato, T., Atsuta, K., Sumi‐Ichinose, C., Ohtsuki, M., Itoh, M., Hishida, H., Tada, S., Udagawa, Y., Nagatsu, T., et al. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.265 · Cited by 9
Cell and molecular biology of nitric oxide synthases.
Féron, O., & Michel, T. M. (2000) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-1-59259-002-5_2 · Cited by 9
Förstermann, U. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00005-8 · Cited by 11
Ikemoto, K., MATSUMOTO, T., Ohtsuki, M., Itoh, M., TADA, S., Udagawa, Y., Sumi‐Ichinose, C., Kondo, K., & NOMURA, T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.012 · Cited by 8
Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization
Ross, L., Danehower, S. C., Proia, A. D., Sontag, M. R., Brown, D. M., Laurenza, A., & Besterman, J. M. (1995) · Experimental Eye Research · doi:10.1016/s0014-4835(05)80139-3 · Cited by 8
Shiraishi, H., Ikemoto, K., Tada, S., Udagawa, Y., Ohtsuki, M., Sumi‐Ichinose, C., Kondo, K., & Nomura, T. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.6361 · Cited by 8
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Hara, Y., Teramoto, K., Ishidate, K., & Arii, S. (2006) · Surgery · doi:10.1016/j.surg.2005.08.019 · Cited by 8
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y, P. A., & Kaski, J. C. (2009) · Drug News & Perspectives · doi:10.1358/dnp.2009.22.4.1367710 · Cited by 8
Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest.
Yamashiro, S., Kuniyoshi, Y., Arakaki, K., Uezu, T., Miyagi, K., & Koja, K. (2006) · PubMed · Cited by 8
Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium
Chen, J., & Meyrick, B. O. (2003) · Laboratory Investigation · doi:10.1038/sj.labinvest.3700027 · Cited by 8
Weiß, G., Grünewald, K., Pantopoulos, K., Goossen, B., Hentze, M. W., Doppler, W., Fuchs, D., Werner‐Felmayer, G., & WACHTER, H. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2554-7_15 · Cited by 8
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Rejdak, K., Empl, M., Giffin, N., Afridi, S. K., Petzold, A., Stelmasiak, Z., Thompson, E. J., Goadsby, P. J., Kaube, H., & Giovannoni, G. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01509.x · Cited by 7
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Chen, Y., Tsai, T., Sung, P., Wang, H., Lin, H.-S., Chang, W., Lu, C., Chen, S., Huang, C.-R., Tsai, N., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19539 · Cited by 5
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Junior, C. V. S., Santos, E. S., Mangione, J. A., Scheinberg, M. A., Souza, J. A., Martinez, E. E., Ramires, J. A. F., & Nicolau, J. C. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.07.003 · Cited by 5
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Cosentino, F., & Lüscher, T. F. (1996) · Methods in neurosciences · doi:10.1016/s1043-9471(96)80022-x · Cited by 5
Xie, L., Hu, D., Qin, H., Zhang, W., Zhang, S., Feng, Y., Yao, H., Xiao, Y., Yao, K., & Huang, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.026 · Cited by 4
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Rudzite, V., Jurika, E., Schroecksnade, K., Kalnins, U., Ērglis, A., Trušinskis, K., & Fuchs, D. (2005) · Pteridines · doi:10.1515/pteridines.2005.16.1.15 · Cited by 4
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Hatakeyama, K. (2003) · Humana Press eBooks · doi:10.1385/1-59259-749-1:251 · Cited by 4
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Gesierich, A., Niroomand, F., & Tiefenbacher, C. (2003) · Cited by 1
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Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner‐Felmayer, G., & Werner, E. R. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0945-5_44 · Cited by 1
Self-citationWerner, E. R., WACHTER, H., & Werner‐Felmayer, G. (1995) · Springer eBooks · doi:10.1007/978-3-642-79343-1_11 · Cited by 1
Self-citationFujimoto, Y., Sakuma, S., Iba, Y., Sasaki, T., & Fujita, T. (2001) · Nitric Oxide · doi:10.1006/niox.2000.0318 · Cited by 1
Andreia, M. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/47t6-7a17 · Cited by 1
Uncoupling of Endothelial Nitric Oxide Synthase in Atherosclerosis
Cunnington, C., & Channon, K. M. (2010) · Atherosclerosis · doi:10.1002/9783527629589.ch14
Regulation of Constitutive and Inducible Nitric Oxide Synthase by Estrogen
Kauser, K. Z., & Rubanyi, G. M. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-58616-3_8
Xie, F., Kissinger, P. T., & Niwa, O. (1997) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826079708013656
Inaba, A., Yokose, S., Fujimoto, K., Katayama, T., & Katoh, S. (2002) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.35.175
Perspectives on tetrahydrobiopterin research.
Sumi‐Ichinose, C., OHTSUKI, M., Shiraishi, H., & Nomura, T. (2001) · Folia Pharmacologica Japonica · doi:10.1254/fpj.118.371
Rudzite, V., Jurika, E., Fuchs, D., Kalnins, U., Ērglis, A., & Trušinskis, K. (2004)
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Nussler, A. K., Heeckt, P. F., & Beger, H. G. (1995) · Springer eBooks · doi:10.1007/978-3-642-79782-8_30
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Katušić, Z. S. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0945-5_43
Santoso, A., Wardani, S. W., & Surayana, K. (2009) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v1i1.84
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Nandi, M. (2004) · UCL Discovery (University College London)
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Gillis, K. A. (2016) · Enlighten: Theses (The University of Glasgow)
Mader, T. L. (2017) · University of Minnesota Digital Conservancy (University of Minnesota)
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a, R. H., & b, E. W. (2003) · AOCS Publishing eBooks · doi:10.1201/9781439822173.ch5
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Availability of Tetrahydrobiopterin and Endothelial Dysfunction
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Hattori, Y., & Kasai, K. (1999) · Springer eBooks · doi:10.1007/978-4-431-67929-5_8
Metadata
- Authors
- Werner-Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G., Schmidt, K., Weiss, G., & Wachter, H.
- Affiliations
- Universität Innsbruck (AT)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 268
- Issue
- 3
- Pages
- 1842-1846
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1496789829
- Cited by
- 263
- References
- 50
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- pteridine synthesis, tetrahydrobiopterin, nitric oxide synthase, cyclic GMP, endothelial cells, GTP cyclohydrolase I, interferon-gamma, TNF-α, lipopolysaccharide, neopterin, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, sepiapterin
- MeSH terms
- Amino Acid Oxidoreductases, Biopterins, Cells, Cultured, Endothelium, Vascular, GTP Cyclohydrolase, Cyclic GMP, Humans, Hypoxanthines, Interferon-gamma, Lipopolysaccharides, Nitric Oxide, Pteridines, Pterins, Tumor Necrosis Factor-alpha, Umbilical Veins, Nitric Oxide Synthase, Neopterin
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