Cited by 217Growth Hormone and Insulin-like Growth FactorsGenomics and Chromatin DynamicsEstrogen and related hormone effects

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Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1

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Powell, D.R., Suwanichkul, A., Cubbage, M.L., DePaolis, L.A., Snuggs, M.B., Lee, P.D.·1991·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)55144-9

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Abstract

Insulin rapidly lowers serum insulin-like growth factor-binding protein-1 (IGFBP-1) levels in vivo. In studies reported here, HEP G2 cells were used as a model system to investigate how insulin achieves this effect. When HEP G2 cells were incubated with 100 nM insulin for 6, 14, or 24 h, IGFBP-1 protein levels in conditioned medium fell to approximately 50% of control values. This apparently was due to a fall in the rate of IGFBP-1 protein synthesis, since HEP G2 cells incorporated 46% less [35S]methionine into IGFBP-1 during a 4-h incubation with 100 nM insulin. IGFBP-1 mRNA levels were similarly affected by 100 nM insulin, falling to 45% of control values after 2 h, and to 9% of control values after 4 h of incubation with this hormone. The fall in IGFBP-1 mRNA level is consistent with data from nuclear transcription assays. HEP G2 nuclei isolated from cells that were incubated with 100 nM insulin for 2 h synthesized only approximately 1/3 the number of IGFBP-1 transcripts as did control nuclei. Further evidence that insulin decreases IGFBP-1 gene transcription comes from transient transfections using chimeric IGFBP-1 promoter-chloramphenicol acetyltransferase reporter gene constructs. IGFBP-1 promoter activity fell to approximately 50% of control values when HEP G2 cells transfected with a construct containing the first 1205 base pairs of the IGFBP-1 promoter were incubated with 100 nM insulin for 6, 14, or 24 h. Insulin lowered both IGFBP-1 protein levels and promoter activity in a dose-dependent manner. A half-maximal effect was found at approximately 1 nM insulin and a maximal effect was found at approximately 10 nM insulin in each instance. Transfections with constructs containing smaller IGFBP-1 promoter fragments showed that the region spanning from 103 to 529 base pairs 5' to the IGFBP-1 mRNA cap site was necessary to demonstrate the inhibitory effect of insulin. These studies indicate that insulin lowers IGFBP-1 protein levels, at least in part, by rapidly decreasing the rate of IGFBP-1 gene transcription, and suggest that this insulin-mediated fall in transcription is conferred through a specific region of the IGFBP-1 promoter.

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A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674
Firefly Luciferase Gene: Structure and Expression in Mammalian Cells
de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088
Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes
Cleveland, D. W., Lopata, M. A., MacDonald, R. J., Cowan, N. J., Rutter, W. J., & Kirschner, M. W. (1980) · Cell · doi:10.1016/0092-8674(80)90238-x · Cited by 1,835
Luciferase reporter gene vectors for analysis of promoters and enhancers.
Nordeen, S. K. (1988) · PubMed · Cited by 994
An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
ELGIN, R. G., Busby, W. H., & Clemmons, D. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3254 · Cited by 685
Binding proteins for the insulin-like growth factors: Structure, regulation and function
Baxter, R. C., & Martin, J. L. (1989) · Progress in Growth Factor Research · doi:10.1016/0955-2235(89)90041-0 · Cited by 568
Insulin Regulates the Serum Levels of Low Molecular Weight Insulin-Like Growth Factor-Binding Protein*
Suikkari, A., Koivisto, V. A., Rutanen, E., YKI-JÄRVINEN, H., Karonen, S.-L., & Seppälä, M. T. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-2-266 · Cited by 483
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.
Sasaki, K., Cripe, T. P., Koch, S. R., Andreone, T. L., Petersen, D. D., Beale, E. G., & Granner, D. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42541-5 · Cited by 428
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.
Short, J. M., Wynshaw-Boris, A. J., Short, H. P., & Hanson, R. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67574-x · Cited by 385

Show all 49 references

Research works printed but not linked: 7

Yeoh, 1988, Acta Endocrinol., 119, 465
Kelly, 1989, In Vitro, 25, 217
Nordeen, 1988, Biotechniques, 6, 454
deWet, 1987, Mol. Cell Biol., 7, 725
Gorman, 1982, Mol. Cell. Biol., 2, 1044
Moss, 1981, Mol. Cell. Biol., 1, 289
Imai, 1990, Mol. Cell. Biol., 10, 4712

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Olivecrona, H., Hilding, A., Ekström, C., Barle, H., Nyberg, B., Möller, C., Delhanty, P. J. D., Baxter, R. C., Angelin, B., Ekström, T. J., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5466 · Cited by 69
Diabetes, pancreatic cancer, and metformin therapy
Gong, J., Robbins, L., Lugea, A., Waldron, R. T., Jeon, C. Y., & Pandol, S. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00426 · Cited by 71
Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats.
Tran, T. T., Gupta, N., Goh, T. T., Naigamwalla, D. Z., Chia, M. C., Koohestani, N., Mehrotra, S., McKeown‐Eyssen, G., Giacca, A., & Bruce, W. R. (2003) · PubMed · Cited by 67
Phosphatidylinositol 3′-Kinase and p70s6k Are Required for Insulin but Not Bisperoxovanadium 1,10-Phenanthroline (bpV(phen)) Inhibition of Insulin-like Growth Factor Binding Protein Gene Expression
Band, C. J., & Posner, B. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.138 · Cited by 66
Diabetes mellitus and metformin in hepatocellular carcinoma
Fujita, K., Iwama, H., Miyoshi, H., Tani, J., Oura, K., Tadokoro, T., Sakamoto, T., Nomura, T., Morishita, A., Yoneyama, H., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i27.6100 · Cited by 68
Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies
Essaouiba, A., Okitsu, T., Kinoshita, R., Jellali, R., Shinohara, M., Danoy, M., Legallais, C., Sakai, Y., & Leclerc, É. (2020) · Biochemical Engineering Journal · doi:10.1016/j.bej.2020.107783 · Cited by 66
Height, predictors of C-peptide and cancer risk in men
Giovannucci, E. L. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh020 · Cited by 64
Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes
Hivert, M.-F., White, F., Allard, C., James, K., Majid, S., Aguet, F., Ardlie, K. G., Florez, J. C., Edlow, A. G., Bouchard, L., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02936-5 · Cited by 62
Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.
Allander, S. V., Larsson, C., Ehrenborg, E., Suwanichkul, A., Weber, G., Morris, S. L., Bajalica, S., Kiefer, M. C., Luthman, H., & Powell, D. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34142-x · Cited by 62
Self-citation
Insulin-like growth factor binding protein-1 levels in the diagnosis of hypoglycemia caused by hyperinsulinism
Katz, L. E. L., Satin-Smith, M. S., Collett‐Solberg, P. F., THORNTON, P. S., Baker, L., Stanley, C. A., & Cohen, P. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70153-7 · Cited by 60
Cardio-oncology Related to Heart Failure
Blaes, A. H., Prizment, A. E., Koene, R. J., & Konety, S. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.12.006 · Cited by 63
Identification of a promoter element which participates in cAMP-stimulated expression of human insulin-like growth factor-binding protein-1
Suwanichkul, A., DePaolis, L. A., Lee, P., & Powell, D. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98409-7 · Cited by 58
Self-citation
The Rat Pyruvate Carboxylase Gene Structure
Jitrapakdee, S., Booker, G. W., Cassady, A. I., & Wallace, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20522 · Cited by 56
The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development
Gong, J., Kelekar, G., Shen, J., Shen, J., Kaur, S., & Mita, M. M. (2016) · Targeted Oncology · doi:10.1007/s11523-016-0423-z · Cited by 56
Gender differences in the relation of insulin‐like growth factor binding protein‐1 to cardiovascular risk factors: a population‐based study
Undén, A., Elofsson, S., & Brismar, K. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02306.x · Cited by 54
Activation of the human IGFBP-1 gene promoter by progestin and relaxin in primary culture of human endometrial stromal cells
Gao, J., Mazella, J., & Tseng, L. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90049-3 · Cited by 52
Polymorphism of the insulin gene is associated with increased prostate cancer risk
Ho, G., Melman, A., Liu, S. M., Li, M., Yu, H., Negassa, A., Burk, R. D., Hsing, A. W., Ghavamian, R., & Chua, S. C. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600747 · Cited by 52
Glucagon stimulates insulin-like growth factor binding protein-1 secretion in healthy subjects, patients with pituitary insufficiency, and patients with insulin-dependent diabetes mellitus
Hilding, A., Brismar, K., Thoren, M., & Hall, K. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.5.1142 · Cited by 51
Colon Cancer Prevention through Probiotics: An Overview
Korada, S. K. (2015) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000329 · Cited by 50
Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells
Kalme, T., Koistinen, H. K., Loukovaara, M. J., Koistinen, R. A., & Leinonen, P. J. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00268-1 · Cited by 49
Insulin-like growth factor bioactivity and its modification in growth hormone resistant states
Donaghy, A. J., & Baxter, R. C. (1996) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(96)80560-x · Cited by 48
Salmon serum 22 kDa insulin-like growth factor-binding protein (IGFBP) is IGFBP-1
Shimizu, M., Dickey, J. T., Fukada, H., & Dickhoff, W. W. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05880 · Cited by 46
Hormonal regulation of circulating insulin-like growth factor-binding protein-1 phosphorylation status
Westwood, M., Gibson, M., Williams, A. C., Clayton, P., Hamberg, O., Flyvbjerg, A., & White, A. E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.12.3520 · Cited by 45
Noncompetitive ELISA for human serum insulin-like growth factor-I
Khosravi, M. J., Diamandi, A., Mistry, J., & Lee, P. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.8.1147 · Cited by 44
Self-citation
Differential regulation of insulin‐like growth factor binding protein (IGFBP)‐2 mRNA in liver and bone cells by insulin and retinoic acid in vitro
Schmid, C., Schläpfer, I., WALDVOGEL, M., Meier, P. J., Schwander, J., Böni‐Schnetzler, M., Zapf, J., & Froesch, E. R. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80520-q · Cited by 44
Nutrition and skin
Pappas, A., Liakou, A. Ι., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9374-z · Cited by 47
O6-Methylguanine-DNA Methyltransferase Leu84Phe and Ile143Val Polymorphisms and Risk of Colorectal Cancer in the Nurses’ Health Study and Physicians’ Health Study (United States)
Tranah, G. J., Bugni, J. M., Giovannucci, E. L., Ma, J., Fuchs, C. S., Hines, L. M., Samson, L. D., & Hunter, D. J. (2006) · Cancer Causes & Control · doi:10.1007/s10552-006-0005-y · Cited by 41
Physiological Differences in Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Phosphorylation in IGFBP-1 Transgenic Mice
Sakai, K., D’Ercole, A. J., Murphy, L. J., & Clemmons, D. R. (2001) · Diabetes · doi:10.2337/diabetes.50.1.32 · Cited by 41
The effect of environmental Bisphenol A exposure on breast cancer associated with obesity
Engin, A. B., & Engin, A. (2020) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2020.103544 · Cited by 41
Regulation of immunoreactive insulin-like growth factor binding protein-6 in normal and transformed human fibroblasts
Martin, J. L., Coverley, J. A., & Baxter, R. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78147-2 · Cited by 40
Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women
Söderberg, S., Åhrén, B., Eliasson, M., Dinesen, B., Brismar, K., & Olsson, T. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440283 · Cited by 39

Authors: Powell, D. R., Suwanichkul, A., Cubbage, M. L., DePaolis, L. A., Snuggs, M. B., & Lee, P. D.
Affiliations: Baylor College of Medicine (US)
ORCID: Powell, D.R.
Lee, P.D.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1991-10
Volume: 266
Issue: 28
Pages: 18868-18876
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)55144-9
OpenAlex: W1578799040
Cited by: 217
References: 49
Citations by year: 2026: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 5 · 2017: 2 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
FWCI: 9.56
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10606 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 38773)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: insulin, IGFBP-1, transcriptional repression, HepG2 cells, insulin signaling, gene expression regulation, promoter activity, dose-dependent effects, methionine incorporation, mRNA levels, transient transfection, chloramphenicol acetyltransferase
MeSH terms: Carrier Proteins, Gene Expression Regulation, Humans, Insulin, Insulin-Like Growth Factor I, Liver Neoplasms, Precipitin Tests, Promoter Regions, Genetic, Thymidine Kinase, Transcription, Genetic, Tumor Cells, Cultured, Insulin-Like Growth Factor Binding Proteins

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Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1

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